研究成果

2010

  • Furumai R, Uchida K, Komi Y, Yoneyama M, Ishigami K, Watanabe H, Kojima S, Yoshida M
    Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.
    Cancer Sci.2010 Nov;101(11).

  • Nishimura, S., Arita, Y., Honda, M., Iwamoto, K., Matsuyama, A., Shirai, A., Kawasaki, H., Kakeya, H., Kobayashi, T., Matsunaga, S., and Yoshida, M.
    Marine antifungal theonellamides target 3b-hydroxysterol to activate Rho1 signaling.
    Nature Chem. Biol. 2010 Jul;6(7).

  • Islam, N. M., Kato, T., Nishino, N., Kim, H.-J., Ito, A., and Yoshida, M.
    Bicyclic peptides as potent inhibitors of histone deacetylases: Optimization of alkyl loop length.
    Bioorg Med Chem Lett. 2010 Feb 1;20(3):997-9.

  • Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H., and Yoshida, M.
    A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.
    Biochem Biophys Res Commun. 2010 Apr 9;394(3):569-73.

  • Schneider-Poetsch, T., Usui, T., Kaida, D., and Yoshida, M.
    Garbled messages and corrupted translations.
    Nat Chem Biol. 2010 Mar;6(3):189-198.

  • Iwasa, E., Hamashima, Y., Fujishiro, S., Higuchi, E., Ito, A., Yoshida, M., and Sodeoka, M.
    Total synthesis of (+)-chaetocin and its analogs: Their histone methyltransferase G9a inhibitory activity.
    J Am Chem Soc. 2010 Mar 31;132(12):4078-9.

  • Jung, I., Matsuyama, A., Yoshida, M., and Kim, D.
    PostMod: sequence based prediction of kinase-specific phosphorylation sites with indirect relationship.
    BMC Bioinformatics. 2010 Jan 18;11.

2009

  • Izawa, M., Takekawa, O., Arie, T., Teraoka, T., Yoshida, M., Kimura, M., and Kamakura, T.
    Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae.
    J. Gen. Appl. Microbiol. 2009 Sep 22;106(38):16257-62.

  • Sasaki, K., Ito, T., Nishino, N., Khochbin, S., and Yoshida, M.
    Real-time imaging of histone H4 hyperacetylation in living cells.
    Proc. Natl. Acad. Sci. U.S.A. 2009 Sep 22;106(38):16257-62.

  • Sato, M., Okada, N., Kakui, Y., Yamamoto, M., Yoshida, M., and Toda, T.
    Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast.
    EMBO Rep. 2009 Aug 21.

  • Ho CH, Magtanong L, Barker SL, Gresham D, Nishimura S, Natarajan P, Koh JL, Porter J, Gray CA, Andersen RJ, Giaever G, Nislow C, Andrews B, Botstein D, Graham TR, Yoshida M, Boone C.
    A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.
    Nat Biotechnol. 2009 Apr;27(4):369-77.

  • Ueda JY, Hwang JH, Maeda S, Kato T, Ochiai A, Isshiki K, Yoshida M, Takagi M, Shin-Ya K.
    JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634.
    J Antibiot (Tokyo). 2009 May;62(5):283-5.

  • Fukuda I, Ito A, Uramoto M, Saitoh H, Kawasaki H, Osada H, Yoshida M.
    Kerriamycin B inhibits protein SUMOylation.
    J Antibiot (Tokyo). 2009 Apr;62(4):221-4.

  • Fukuda I, Ito A, Hirai G, Nishimura S, Kawasaki H, Saitoh H, Kimura K, Sodeoka M, Yoshida M.
    Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
    Chem Biol. 2009 Feb 27;16(2):133-40.

  • Ueoka R, Ito A, Izumikawa M, Maeda S, Takagi M, Shin-Ya K, Yoshida M, van Soest RW, Matsunaga S.
    Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.
    Toxicon. 2009 May;53(6):680-4.

  • Zhou J, Vos CC, Gjyrezi A, Yoshida M, Khuri FR, Tamanoi F, Giannakakou P.
    The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
    J Biol Chem. 2009 Apr 10;284(15):9648-55.

  • Ling F, Yoshida M, Shibata T.
    Heteroduplex joint formation free of net topological change by Mhr1, a mitochondrial recombinase.
    J Biol Chem. 2009 Apr 3;284(14):9341-53.

  • Hori A, Yoshida M, Shibata T, Ling F.
    Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication.
    Nucleic Acids Res. 2009 Feb;37(3):749-61.

  • Matsuyama, A. and Yoshida, M.
    Systematic cloning of an ORFeome using the Gateway system.
    Methods Mol. Biol. 2009;577:11-24.

2008

  • Dohi Y, Ikura T, Hoshikawa Y, Katoh Y, Ota K, Nakanome A, Muto A, Omura S, Ohta T, Ito A, Yoshida M, Noda T, Igarashi K.
    Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.
    Nat Struct Mol Biol. 2008 Dec;15(12):1246-54.

  • Nishino TG, Miyazaki M, Hoshino H, Miwa Y, Horinouchi S, Yoshida M.
    14-3-3 regulates the nuclear import of class IIa histone deacetylases.
    Biochem Biophys Res Commun. 2008 Dec 19;377(3):852-6.

  • Hoshino I, Matsubara H, Komatsu A, Akutsu Y, Nishimori T, Yoneyama Y, Murakami K, Sakata H, Matsushita K, Miyazawa Y, Brooks R, Yoshida M, Ochiai T.
    Combined effects of p53 gene therapy and leptomycin B in human esophageal squamous cell carcinoma.
    Oncology. 2008 75(1-2):113-9.

  • Tokai T, Takahashi-Ando N, Izawa M, Kamakura T, Yoshida M, Fujimura M, Kimura M.
    4-O-acetylation and 3-O-acetylation of trichothecenes by trichothecene 15-O-acetyltransferase encoded by Fusarium Tri3.
    Biosci Biotechnol Biochem. 2008 Sep;72(9):2485-9.

  • Matsuyama A, Shirai A, Yoshida M.
    A novel series of vectors for chromosomal integration in fission yeast.
    Biochem Biophys Res Commun. 2008 Sep 19;374(2):315-9.

  • Crabb SJ, Howell M, Rogers H, Ishfaq M, Yurek-George A, Carey K, Pickering BM, East P, Mitter R, Maeda S, Johnson PW, Townsend P, Shin-ya K, Yoshida M, Ganesan A, Packham G.
    Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.
    Biochem. Pharmacol. 2008 Aug 15;76(4):463-75.

  • Kamemura K, Ito A, Shimazu T, Matsuyama A, Maeda S, Yao TP, Horinouchi S, Khochbin S, Yoshida M.
    Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
    Biochem Biophys Res Commun. 2008 Sep 12;374(1):84-9.

  • Matsuyama A, Shirai A, Yoshida M.
    A series of promoters for constitutive expression of heterologous genes in fission yeast.
    Yeast. 2008 May;25(5):371-6.

  • Yoshitani A, Ling F, Yoshida M.
    The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage.
    Biosci Biotechnol Biochem. 2008 Jun;72(6):1630-4.

  • Nakao Y, Narazaki G, Hoshino T, Maeda S, Yoshida M, Maejima H, Yamashita JK.
    Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.
    Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4.

  • Kimata Y, Matsuyama A, Nagao K, Furuya K, Obuse C, Yoshida M, Yanagida M.
    Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.
    J Cell Sci. 2008 Apr 1;121(Pt 7):1107-18.

  • Shirai A, Matsuyama A, Yashiroda Y, Hashimoto A, Kawamura Y, Arai R, Komatsu Y, Horinouchi S, Yoshida M.
    Global analysis of gel mobility of proteins and its use in target identification.
    J Biol Chem. 2008 Apr 18;283(16):10745-52. Epub 2008 Feb 21.

  • Yashiroda Y, Matsuyama A, Yoshida M.
    New insights into chemical biology from ORFeome libraries.
    Curr Opin Chem Biol. 2008 Feb;12(1): 55-9. Review.

  • Takahashi-Ando N, Ochiai N, Tokai T, Ohsato S, Nishiuchi T, Yoshida M, Fujimura M, Kimura M.
    A screening system for inhibitors of trichothecene biosynthesis: hydroxylation of trichodiene as a target.
    Biotechnol Lett. 2008 Jun;30(6):1055-9.

  • Matthias P, Yoshida M, Khochbin S.
    HDAC6 a new cellular stress surveillance factor.
    Cell Cycle. 2008 Jan;7(1):7-10.

  • Yoshitani A, Yoshida M, Ling F.
    A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7.
    Biochem Biophys Res Commun. 2008 Jan 1;16(1):437-45.

  • Nishino N, Shivashimpi GM, Soni PB, Bhuiyan MP, Kato T, Maeda S, Nishino TG, Yoshida M.
    Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.
    Bioorg Med Chem. 2008 Jan 4;365(1): 183-8.

2007

  • Lo CW, Kaida D, Nishimura S, Matsuyama A, Yashiroda Y, Taoka H, Ishigami K, Watanabe H, Nakajima H, Tani T, Horinouchi S, Yoshida M.
    Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast.
    Biochem Biophys Res Commun. 2007 Dec 21;364(3): 573-7.

  • Yurek-George A, Cecil AR, Mo AH, Wen S, Rogers H, Habens F, Maeda S, Yoshida M, Packham G, Ganesan A.
    The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.
    J Med Chem. Nov 15;50(23):5720-6. Epub 2007 Oct 24.

  • Shivashimpi GM, Amagai S, Kato T, Nishino N, Maeda S, Nishino TG, Yoshida M.
    Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.
    Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. Epub 2007 Aug 26.

  • Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M.
    Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
    Nat Chem Biol. 2007 Sep;3(9):576-83. Epub 2007 Jul 22.

  • Lee S, Shinji C, Ogura K, Shimizu M, Maeda S, Sato M, Yoshida M, Hashimoto Y, Miyachi H.
    Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
    Bioorg Med Chem Lett. 2007 Sep 1;17(17):4895-900. Epub 2007 Jun 13.

  • Ling F, Hori A, Yoshida M, Shibata T.
    Rolling circle replication: a universal model for controlling mechanisms of mitochondrial DNA copy number.
    Tanpakushitsu Kakusan Koso. 2007 Jul;52(8):886-92. Review. Japanese.

  • Hoshino H, Nishino TG, Tashiro S, Miyazaki M, Ohmiya Y, Igarashi K, Horinouchi S, Yoshida M.
    Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.
    J Biochem (Tokyo). 2007 May;141(5):719-27. Epub 2007 Mar 23.

  • Shimazu T, Horinouchi S, Yoshida M.
    Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.
    J Biol Chem. 2007 Feb 16;282(7):4470-8. Epub 2006 Dec 17.

  • Tsuchiya A, Tashiro E, Yoshida M, Imoto M.
    Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression.
    Oncogene. 2007 Mar 8;26(11):1522-32. Epub 2006 Sep 11.

2006

  • Jang BC, Sung SH, Park JG, Park JW, Suh MH, Choi IH, Yoshida M, Yoo SK, Suh SI.
    Leptomycin B, a metabolite of Streptomyces, inhibits the expression of inducible nitric oxide synthase in BV2 microglial cells.
    Int J Oncol. 2006 Dec;29(6):1509-15.

  • Inoue K, Kobayashi M, Yano K, Miura M, Izumi A, Mataki C, Doi T, Hamakubo T, Reid PC, Hume DA, Yoshida M, Aird WC, Kodama T, Minami T.
    Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression.
    Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2652-9. Epub 2006 Sep 28.

  • Sasaki K, Yoshida M.
    Histone modification enzymes.
    Tanpakushitsu Kakusan Koso, 2006 Nov;51(14 Suppl):2069-75. Review. Japanese.

  • Suzuki T, Kouketsu A, Itoh Y, Hisakawa S, Maeda S, Yoshida M, Nakagawa H, Miyata N.
    Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.
    J Med Chem. 2006 Aug 10;49(16):4809-12.

  • Shinji C, Maeda S, Imai K, Yoshida M, Hashimoto Y, Miyachi H.
    Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors.
    Bioorg Med Chem. 2006 Nov 15;14(22):7625-51. Epub 2006 Jul 31.

  • Matsuyama A, Arai R, Yashiroda Y, Shirai A, Kamata A, Sekido S, Kobayashi Y, Hashimoto A, Hamamoto M, Hiraoka Y, Horinouchi S, Yoshida M.
    ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
    Nat. Biotechnol. 2006 Jul;24(7):841-7. Epub 2006 Jun 25.

  • Shimazu T, Komatsu Y, Nakayama KI, Fukazawa H, Horinouchi S, Yoshida M.
    Regulation of SV40 large T antigen stability by reversible acetylation.
    Oncogene. 2006 Nov 30;25(56):7391-400. Epub 2006 Jun 12.

  • Tomono A, Mashiko M, Shimazu T, Inoue H, Nagasawa H, Yoshida M, Ohnishi Y, Horinouchi S.
    Self-activation of serine/threonine kinase AfsK on autophosphorylation at threonine-168.
    J Antibiot (Tokyo). 2006 Feb;59(2):117-23.

  • Kataoka M, Hashimoto KI, Yoshida M, Nakamatsu T, Horinouchi S, Kawasaki H.
    Gene expression of Corynebacterium glutamicum in response to the conditions inducing glutamate overproduction.
    Lett Appl Microbiol. 2006 May;42(5):471-6.

  • Jeon EJ, Lee KY, Choi NS, Lee MH, Kim HN, Jin YH, Ryoo HM, Choi JY, Yoshida M, Nishino N, Oh BC, Lee KS, Lee YH, Bae SC.
    Bone morphogenetic protein-2 stimulates Runx2 acetylation.
    J Biol Chem. 2006 Jun 16;281(24):16502-11. Epub 2006 Apr 13.

  • Masumi A, Fukazawa H, Shimazu T, Yoshida M, Ozato K, Komuro K, Yamaguchi K.
    Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation.
    Oncogene. 2006 Aug 24;25(37):5113-24. Epub 2006 Apr 3.

  • Tokunaga K, Shibuya T, Ishihama Y, Tadakuma H, Ide M, Yoshida M, Funatsu T, Ohshima Y, Tani T.
    Nucleocytoplasmic transport of fluorescent mRNA in living mammalian cells: nuclear mRNA export is coupled to ongoing gene transcription.
    Genes Cells. 2006 Mar;11(3):305-17.

  • Margolis SS, Perry JA, Weitzel DH, Freel CD, Yoshida M, Haystead TA, Kornbluth S.
    A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.
    Mol Biol Cell. 2006 Apr;17(4):1779-89. Epub 2006 Feb 8.

  • Bhuiyan MP, Kato T, Okauchi T, Nishino N, Maeda S, Nishino TG, Yoshida M.
    Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.
    Bioorg Med Chem. 2006 May 15;14(10):3438-46. Epub 2006 Jan 24.

  • Lee KH, Nishimura S, Matsunaga S, Fusetani N, Ichijo H, Horinouchi S, Yoshida M.
    Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide.
    Biosci Biotechnol Biochem. 2006 Jan;70(1): 161-71.

  • Hirokawa Y, Nheu T, Grimm K, Mautner V, Maeda S, Yoshida M, Komiyama K, Maruta H.
    Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice.
    Cancer Biol Ther. 2006 Mar;5(3):305-9. Epub 2006 Mar 12.

  • Cheng Q, Balzer E, Miller S M, Yoshida M, and Wong J C
    Effect of histone deacetylase inhibitors on tubulin acetylation and development in Volvox carteri (Volvocales).
    J. Phycol. 2006 42: 417-422

  • Shirai A, Matsuyama A, Yashiroda Y, Arai R, and Yoshida M.
    Rapid and reliable preparation of total cell lysates from fission yeast.
    Nat. Protocols. DOI: 10.1038/nprot.2006.191.:, 2006.

2005

  • Tsuchiya A, Tashiro E, Yoshida M, Imoto M.
    Involvement of nuclear accumulation of heat shock protein 27 in leptomycin B-induced apoptosis in HeLa cells.
    J Antibiot (Tokyo). 2005 Dec;58(12):810-6.

  • Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M, Hui CC.
    Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.
    Differentiation. 2005 Oct;73(8):397-405.

  • Iwabata H, Yoshida M, Komatsu Y.
    Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies.
    Proteomics. 2005 Dec;5(18):4653-64.

  • Shinji C, Nakamura T, Maeda S, Yoshida M, Hashimoto Y, Miyachi H.
    Design and synthesis of phthalimide-type histone deacetylase inhibitors.
    Bioorg Med Chem Lett. 2005 Oct 15;15(20):4427-31.

  • Col E, Caron C, Chable-Bessia C, Legube G, Gazzeri S, Komatsu Y, Yoshida M, Benkirane M, Trouche D, Khochbin S.
    HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.
    EMBO J. 2005 Jul 20;24(14):2634-45. Epub 2005 Jul 7.

  • Lee KH, Nishimura S, Matsunaga S, Fusetani N, Horinouchi S, Yoshida M.
    Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products.
    Cancer Sci. 2005 Jun;96(6):357-64.

  • Kovacs JJ, Murphy PJM, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP.
    HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of clucocorticoid receptor.
    Mol Cell. 2005 May 27;18(5):601-7.

  • Tatematsu K, Yoshimoto N, Koyanagi T, Tokunaga C, Tachibana T, Yoneda Y, Yoshida M, Okajima T, Tanizawa K, Kuroda S.
    Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins.
    J Biol Chem. 2005 Jun 17;280(24):22937-44. Epub 2005 Apr 15.

  • Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, Yoshida M, Toi M.
    Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.
    Oncogene. 2005 Jun 30;24(28):4531-9.

  • Nishimura S, Matsunaga S, Yoshida M, Hirota H, Yokoyama S, Fusetani N.
    13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit.
    Bioorg Med Chem. 2005 Jan 17;13(2):449-54.

2004

  • Matsuyama A, Shirai A, Yashiroda Y, Kamata A, Horinouchi S, Yoshida M.
    pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast.
    Yeast. 2004 Nov;21(15):1289-305.

  • Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S, Yoshida M, Nakayama K, Nakayama KI.
    Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
    Nat Cell Biol. 2004 Dec;6(12):1229-35. Epub 2004 Nov 7.

  • Motoyoshi H, Horigome M, Ishigami K, Yoshida T, Horinouchi S, Yoshida M, Watanabe H, Kitahara T.
    Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
    Biosci Biotechnol Biochem. 2004 Oct;68(10):2178-82.

  • Nishino N, Jose B, Shinta R, Kato T, Komatsu Y, Yoshida M.
    Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
    Bioorg Med Chem. 2004 Nov 15;12(22):5777-84.

  • Heltweg B, Dequiedt F, Marshall BL, Brauch C, Yoshida M, Nishino N, Verdin E, Jung M.
    Subtype selective substrates for histone deacetylases.
    J Med Chem. 2004 Oct 7;47(21):5235-43.

  • Jose B, Oniki Y, Kato T, Nishino N, Sumida Y, Yoshida M.
    Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.
    Bioorg. Med. Chem. Lett. 2004 Nov 1;14(21):5343-6.

  • Jang BC, Paik JH, Jeong HY, Oh HJ, Park JW, Kwon TK, Song DK, Park JG, Kim SP, Bae JH, Mun KC, Suh MH, Yoshida M, Suh SI.
    Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells.
    Biochem Pharmacol. 2004 Jul 15;68(2):263-74.

  • Suzuki H, Tashiro S, Hira S, Sun J, Yamazaki C, Zenke Y, Ikeda-Saito M, Yoshida M, Igarashi K.
    Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1.
    EMBO J. 2004 Jul 7;23(13):2544-53. Epub 2004 Jun 3.

  • Yoshida M, Sazer S.
    Nucleocytoplasmic transport and nuclear envelope integrity in the fission yeast Schizosaccharomyces pombe.
    Methods, 2004 Jul;33(3):226-38.

  • Nishino N, Yoshikawa D, Watanabe LA, Kato T, Jose B, Komatsu Y, Sumida Y, Yoshida M.
    Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.
    Bioorg. Med. Chem. Lett. 2004 May 17;14(10):2427-31.

  • Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K.
    Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.
    Mol Cell Biol. 2004 Apr;24(8):3473-84.

  • Jose B, Okamura S, Kato T, Nishino N, Sumida Y, Yoshida M.
    Toward an HDAC6 inhibitor: synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from alpha-tubulin sequence.
    Bioorg. Med. Chem. 2004 Mar 15;12(6):1351-6.

  • Uchida S, Ohtsubo M, Shimura M, Hirata M, Nakagama H, Matsunaga T, Yoshida M, Ishizaka Y, Yamashita K.
    Nuclear export signal in CDC25B.
    Biochem Biophys Res Commun. 2004 Mar 26;316(1):226-32.

  • Watanabe LA, Jose B, Kato T, Nishino N, and Yoshida M.
    Synthesis of L-a-amino-w-bromoalkanoic acid for side chain modification.
    Tetrahedron Lett. 45: 491-494, 2004.

2003

  • Nishino N, Jose B, Okamura S, Ebisusaki S, Kato T, Sumida Y, Yoshida M.
    Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.
    Org Lett. 2003 Dec 25;5(26): 5079-82.

  • Yoshida M, Shimazu T, Matsuyama A.
    Protein deacetylases: enzymes with functional diversity as novel therapeutic targets.
    Prog Cell Cycle Res. 2003;5: 269-78. Review.

  • Margolis SS, Walsh S, Weiser DC, Yoshida M, Shenolikar S, Kornbluth S.
    PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.
    EMBO J. 2003 Nov 3;22(21):5734-45.

  • Yoshida M, Matsuyama A, Komatsu Y, Nishino N.
    From discovery to the coming generation of histone deacetylase inhibitors.
    Curr Med Chem. 2003 Nov;10(22): 2351-8. Review.

  • Lee JH, Chang SH, Shim JH, Lee JY, Yoshida M, Kwon H.
    Cytoplasmic localization and nucleo-cytoplasmic shuttling of BAF53, a component of chromatin-modifying complexes.
    Mol Cells. 2003 Aug 31;16(1):78-83.

  • Yashiroda Y, Yoshida M.
    Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs.
    Curr Med Chem. 2003 May;10(9): 741-8. Review.

  • Tajima Y, Goto K, Yoshida M, Shinomiya K, Sekimoto T, Yoneda Y, Miyazono K, Imamura T.
    Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7.
    J Biol Chem. 2003 Mar 21;278(12):10716-21. Epub 2003 Jan 7.

  • Komatsu Y, Yukutake Y, Yoshida M.
    Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure.
    J Immunol Methods. 2003 Jan 15;272(1-2): 161-75.

  • Jang BC, Munoz-Najar U, Paik JH, Claffey K, Yoshida M, Hla T.
    Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression.
    J Biol Chem. 2003 Jan 31;278(5):2773-6. Epub 2002 Dec 4.

  • Bradney C, Hjelmeland M, Komatsu Y, Yoshida M, Yao TP, Zhuang Y.
    Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
    J Biol Chem. 2003 Jan 24;278(4):2370-6. Epub 2002 Nov 14.

2002

  • Matsuyama A, Shimazu T, Sumida Y, Saito A, Yoshimatsu Y, Seigneurin-Berny D, Osada H, Komatsu Y, Nishino N, Khochbin S, Horinouchi S, Yoshida M.
    In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
    EMBO J. 2002 Dec 16;21(24): 6820-31.

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