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Postdoctoral Researcher

Ai Niitsu

EDUCATION
2007
B.S., Department of Chemistry, School of Science, University of Tokyo
2009
M.S., Department of Chemistry, School of Science, University of Tokyo
2012
Ph.D.(Science), Department of Chemistry, School of Science, University of Tokyo
RESEARCH AND TEACHING EXPERIENCES
2009-2012
Research Fellowship for Young Scientists from Japan Society for the Promotion of Science
2012-2016
Research Accociate, University of Bristol, UK
2016-present
Postdoctoral Reseacher, RIKEN, Quantitative Biology Centre
RESEARCH PROJECTS
    Application of the free-energy calculation for the ligand-receptor binding to drug discovery
PUBLICATIONS

Peer-reviewed journal articles

  1. An autonomously assembled octameric transmembrane helix barrel

    K.R. Mahendran*, A. Niitsu*, L. Kong, R.B. Session, A. R. Thomson, D.N. Woolfson, and H. Bayley *contributed equally
    Nature Chem., in press

  2. Ophiobolin O and 6-epi-ophiobolin O, two new cytotoxic sesterterpenes from the marine derived fungus Aspergillus sp

    D. Zhang, S. Fukuzawa, M. Satake, X. Li, T. Kuranaga, A. Niitsu, K. Yoshizawa, and K. Tachibana
    Nat. Prod. Commun., 7, 1411-1414 (2012)

  3. Binding mechanism analysis between DIVS6 model peptides of voltage-gated sodium channel and a lipid soluble alkaloid veratridine using solution NMR

    A. Niitsu, T. Yamagaki, M. Harada, and K. Tachibana
    Bioorg. Med. Chem., 20, 2796-2802 (2012)

  4. Two new indole alkaloids, 2-(3,3-dimethylprop-1-ene)-costaclavine and 2-(3,3-dimethylprop-1-ene) -epicostaclavine, from the marine-derived fungus Aspergillus fumigatus

    D. Zhang, M. Satake, S. Fukuzawa, K. Sugahara, A. Niitsu, T. Shirai, and K. Tachibana
    J. Nat. Med., 66, 222-226 (2012)

  5. Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate

    A. Niitsu, M. Harada, T. Yamagaki and K. Tachibana
    Bioorg. Med. Chem., 16, 3025–3031 (2008)


Review article

  1. De novo protein design: how do we expand into the universe of possible protein structures?

    D.N. Woolfson, G.J. Bartlett, A.J. Burton, J.W. Heal, A. Niitsu, A.R. Thomson, and C.W. Wood
    Curr. Opin. Struct. Biol., 33, 16–26 (2015)

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