多方向かつ段階的に進行する細胞分化における運命決定メカニズムの解明究領域略称:細胞運命制御

主な業績

2010年度 - 原著論文

* correspondence

Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H. Furusawa J-I, Ohtani M, Fujii H, and *Koyasu S.
Innate production of Th2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphocytes.
Nature. 463: 540-544, 2010.

Ikawa T, Hirose S, Masuda K, Kakugawa K, Satoh R, Shibano-Satoh A, Kominami R, Katsura Y, *H Kawamoto.
An essential developmental checkpoint for production of the T cell lineage.
Science. 329: 93-96 2010.

Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz L,D, and *Ishikawa F.
Cell cycle entry potentiates elimination of quiescent chemotherapy-resistant human AML stem cells.
Nat Biotechnol. 28-3: 275-280, 2010.

Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, and *Ellmeier W,
The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes.
Nat Immunol. 11: 442-448, 2010.

*Yokoyma A, Lin M, Naresh A, Kitabayashi I, and *Cleary M.L.
A higher-order complex containing AF4- and ENL-family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
Cancer Cell. 17: 198-212, 2010.

Oguro H, Jin Y, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, * Iwama A.
Poised lineage specification in multipotent hematopoietic progenitor cells by the polycomb protein Bmi1.
Cell Stem Cell. 5: 279-286, 2010.

Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasaza M, Tanaka S, Takagi S, Uchida N, Suzuki N, Sone A, Najima Y, Ozawa H, Wake A, Taniguchi S, Shultz L,D, Ohara O, and *Ishikawa F.
Identification of therapeutic targets for quiescent chemotherapy-resistant human AML stem cells.
Science Translational Medicine. 2: 1-11, 2010.

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, and *Kitamura T.
TIM1 is an endogenous ligand for LMIR5/CD300b and LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
J Exp Med. 207: 1501-1511, 2010.

Engel I, Hammond K, Sullivan B, He X, Taniuchi I, Kappes D, and *Kronenberg M.
Co-receptor choice by Vα14 iNKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.
J Exp Med. 207: 1015-1029, 2010.

Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, and *Nakanishi M,
Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.
Genes and Dev. 24: 333-338, 2010.

Lee K, Ambrose Z, Martin T.D, Oztop I, Mulky A, Julias J.G, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman D.R, Coffin J.M, Hughes S.H, Unutmaz D, Engelman A, and *Kewalramani V.N.
Flexible Use of Nuclear Import Pathways by HIV-1,
Cell Host Microbe. 7: 221-233, 2010.

Onitsuka I, Tanaka M, and *Miyajima A.
Characterization and functional analyses of hepatic mesothelial cells in mouse liver development.
Gastroenterology. 138: 1525-1536, 2010.

Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda H, Honda Zi, and *Honda H.
p130Cas plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration.
Hepatology. 52: 1089-1099, 2010.

Tazaki T, Sasaki T, (These two authors contributed equally to this work) Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda H, Honda Z-I, and *Honda H,. p130Cas plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration.
Hepatology.52(3):1089-99,2010.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, and Iwama A.
The polycomb-group gene Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and independent manners.
Hepatology. 2010 Jun 11, [Epub ahead of print],

Lordier, L., Chang, Y., Jalil, A., Aurade, F., Garcon, L., Lecluse, Y.,
Larbret, F., Kawashima, T., Kitamura, T., Larghero, J., Debili, N. and Vainchenker, W. (2010) Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.
Blood. 116:3245-3255, 2010.

Kato N, Kitaura J Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y,Harada H, and Kitamura T. (2010)
Two type of C/EBPa mutations play distinct roles in leukemogenesis: Lessons from clinical data and BMT models.
Blood. 2010 Sep 30. [Epub ahead of print].

Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, and Kitamura T.
AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.
Leukemia. 24:1018-1024, 2010.

Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, *Kitamura T, and *Chiba S.
Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia.
Blood. 115: 2872-2881, 2010.

*Motohashi H, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, Katsuoka F, Aburatani H, Bresnick EH, and Yamamoto M,
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.
Blood. 115: 677-686, 2010.

Hirose K, *Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram S,H, Gottgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look A,T, Matsui H, Inaba T, Sugita K.
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood. 116(6):962-70,2010.

Meek B, Cloosen S, Borsotti C, Elssen J V, Vanderlocht J, Schnijderberg M, Poel M van der, Leewis B, Hesselink R, Manz M G, Katsura Y, Kawamoto H, * Germeraad W TV, and Bos G MJ.
In vitro human G-CSF mobilized CD34+ derived T-cell progenitors fully mature in vivo.
Blood. 115: 261-264, 2010.

Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii S-I, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, and *Taniguchi M.
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Va14-Ja18 TCRa gene.
Blood. 115: 230-237, 2010.

Jacob B, Osato M, Yamashita N, Wang C.Q, Taniuchi I, Littman D.R, and *Ito Y.
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
Blood. 115: 1610-20, 2010.

Bee T, Swiers G, Muroi S, Pozner A, Nottingham W, Santos AC, Li P-S, Taniuchi I, and *de Bruijn M.
Non-redundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.
Blood. 115: 3042-50, 2010.

Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, Luche H, Fehling H,J, Casellas R, Kanagawa O, Miyawaki A, and *Kurosaki T,
Preferential localization of IgG memory B cells adjacent to contracted germinal centers.
Proc Natl Acad Sci USA. 107 (27): 12192-12197, 2010.

Shultz L,D, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, and *Ishikawa F.
Proc Natl Acad Sci USA.Jul 6 2010 (Epub ahead of print).

Yamauchi S, Ito H, and *Miyajima A.
IkBh a nuclear IkB protein positively regulates the NF-κB-mediated expression of pro-inflammatory cytokines.
Proc Natl Acad Sci USA. 107: 11924-11929, 2010.

Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw A,K, Banerjee B, Hande P,M, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, and *Nakanishi M.
Cooperative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo.
EMBO J. 29(20):3558-70,2010.

Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, and *Kitamura T.
AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.
Leukemia. 24: 1018-1024, 2010.

Akahane K, *Inukai T, Inaba T, Kurosawa H, Look A,T, Kiyokawa N, Fujimoto J, Goto H, Endo M, Zhang X, Hirose K, Kuroda I, Honna H, Kagami J, Goi K, Nakazawa S, and Sugita K.
Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
Leukemia. 24: 865-869, 2010.

Tanaka H,Takeuchi M, Takeda Y, Sakai S, Oda K, Abe D, Ohwada C, Ozawa S, Sakaida E, Shimizu N, Saito Y, Miyagi S, Iwama A, and Nakaseko C.
Identification of a novel TEL-Lyn fusion gene in primary myelofibrosis.
Leukemia. 24: 197, 2010.

Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, and Iwama A.
The polycomb-group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.
J Hepatology. 52: 854-863, 2010.

Miyaoka Y, Tanaka M, Imamura T, Takada S, and *Miyajima A.
A novel regulatory mechanism for FGF18 signaling involving cysteine-rich FGF receptor (Cfr) and Delta-like protein (Dlk).
Development. 137: 159-167, 2010.

Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda Z Wolff L, Inaba T, *Honda H.
Identification of Zfp521/ZNF521 as acooperative gene for E2A-HLF to develop acute B-lineage leukemia.
Oncogene. 29: 1963-1975, 2010.

Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, and Mano H.
Array-based genomic resequencing of human leukemia.
Oncogene. 24: 3723-3731, 2010.

Shimada M, Haruta M, Niida H, Sawamoto K, and *Nakanishi M.
PP1g is a phosphatase responsible for dephosphorylation of histone H3 at threonine 11 after DNA damage.
EMBO rep. 11(11):883-9. 2010.

Miyazaki K, *Miyazaki M, Guo Y, Yamasaki N, Kanno M, Honda Z, Oda H , Kawamoto H, *Honda H.
The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells..
J. Immunol.185:7330-7339, 2010.

Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, *Motohashi H, and *Yamamoto M,
Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.
Mol Cell Biol. 30: 2668-2680, 2010.

Yajima A, Inaba M, Tominaga Y, Nishizawa Y, Ikeda K, *Ito A.
Increased osteocyte death and mineralization inside bone after parathyroidectomy in patients with secondary hyperparathyroidism.
J Bone Miner Res. 2010 WebFirst(doi: 10,1002/jbmr,126 (p n/a))

Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takahashi M, Maehara A, Oki T, Kajikawa M, Takai T, *Kitamura T, and *Kitaura J.
Characterization of leukocyte mono-Ig receptor 7 (LMIR7)/CLM3 as an activating receptor: Its similarities to and differences from LMIR4/CLM5.
J Biol Chem, 285(46):35274-83, 2010.

Kobayashi E, *Shimizu R, Kikuchi Y, Takahashi S, and *Yamamoto M.
Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain.
J Biol Chem. 285: 773-783, 2010.

Okuya M, *Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura R, A, Sugita K, Arisaka O, Look A, T, Inaba T.
Upregulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.
J Biol Chem. 285: 1850-1860, 2010.

Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonehara S, Kitamura T, Nosaka T, and *Sasai Y.
Cv2 functioning as a pro-BMP factor via twisted gastulation is required for early development of nephron precursors.
Dev Biol. 337: 405-414, 2010.

Nagamachi A, Htun P,W, Ma F, K, Miyazaki Yamasaki N, Kanno M, Inaba T, Honda Z,I, Okuda T, Oda H, Tsuji K, *Honda H.
A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis hematopoiesis and leukemogenesis in a knock-in mouse model.
Dev Biol. 345(2):226-36,2010.

Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S-i ,Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H ,Shimokawa I, Song Si-Y, Matsuno A, Mizutani A, Sawabe M, Chao MV,Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW ,Guarente L, *Setou M.
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals.
PLoS ONE. 5(7): e11755, doi:10,1371/journal,pone,0011755

Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, and Iwama A.
A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/Arf locus through polycomb repressive complex 1.
PLoS ONE. 10,1371/journal,pone,0012373 2010,

Vroegindeweij E, Crobach S, Itoic M, Satoha R, Zuklys S, Happee C, Germeraad W TV, Cornelissen J J, Cupedo T, Hollander G A, Kawamoto H, and * van Ewijk W.
Thymic cysts originate from Foxn1 positive thymic medullary epithelium.
Mol Immunol. 47: 1106-1113, 2010.

Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A.
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Exp Hematol. 38: 696-706, 2010.

Okano S, Zhou L, Kusaka T, Shibata K, Shimizu K, Gao X, Kikuchi Y, Togashi Y, Hosoya T, Takahashi S, *Nakajima O, and *Yamamoto M,
Indispensable function for embryogenesis expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse.
Genes Cells.15: 77-89, 2010.

Hirano M, Hoshida T, Sakaue-Sawano A, and *Miyawaki A.
A poly(dimethylsiloxane)-based device enabling time-lapse imaging with high spatial resolution.
Biochem Biophys Res Commun.392 (3): 307-310, 2010.

Ohoka N, Sakai S, Onozaki K, Nakanishi M, and Hayashi H,
Anaphase promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.
Biochem Biophys Res Commun. 392: 289-294, 2010.

Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Iwamoto S, Hori H, Komada Y, Uchida A Hayashi Y, Kitamura T. and Nosaka T.
Expression of ADAMTS4 in Ewing’s sarcoma.
Int. J. of Oncol .37:569-581, 2010.

Takeuchi M, Kaneko H, Nishikawa K, Kawakami K, Yamamoto M, and *Kobayashi M,
Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis.
Dev Growth Differ.52: 245-250, 2010.

*Yanai H, Nakura K, Hijioka S, Kamei A, Ikari T, IshikawaY, Shinozaki E, Mizunuma N, Hatake K, and Miyajima A.
Dlk-1 a cell surface antigen on hepatic stem/progenitor cells is expressed in hepatocellular colon pancreas and breast carcinomas at a high frequency.
J Biochem. 148: 85-92, 2010.

Kim K, Suzuki N, Ohneda K, Minegishi N, and *Yamamoto M,
Fractionation of mature eosinophils in GATA-reporter transgenic mice.
Tohoku J Exp Med. 220: 127-138, 2010.

Koizumi T, Negishi M, Nakamura S, Oguro H, Satoh K, Ichinose M, and Iwama A.
Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells.
Int J Hematol. 91: 611, 2010.

Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, and Hayashi H,
Dual mode of regulation of cell division cycle 25A protein by TRB3.
Biol Pharm Bull. 33: 1112-1116, 2010.

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