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Members

Kazuhisa Kinoshita, Ph. D.

Education

1989-93 Tohoku University, Sendai, Japan. B. S., Biology, 1993
1993-95 Kyoto University, Kyoto, Japan. M. S., Molecular Biology, 1995
1995-98 Kyoto University, Kyoto, Japan. Ph. D., Molecular Biology, 1998

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Research and Professional Experience

1998-2000 Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
2000-01 Postdoctoral Fellow, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
2001-06 Staff Scientist, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
2006-07 Research Scientist, Kyoto University, Kyoto, Japan
2007-present Senior Research Scientist, RIKEN, Wako, Japan

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Awards and Professional Activities

1998 Research Fellowship of the Japan Society for the Promotion of Science
1998-2000 Long-Term Fellowship of the Human Frontier Science Program
2002 Research Fellowship of the Uehara Memorial Foundation
2004- Member, The Molecular Biology Society of Japan

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Publication List

  • Kinoshita, K., T. J. Kobayashi and T. Hirano. (2015). Balancing acts of two HEAT subunits of condensin I support dynamic assembly of chromosome axes. Dev Cell. 33:94-106.
    PMID: 25850674
  • Brunet, S., J. Dumont, K. W. Lee, K. Kinoshita, P. Hikal, O. J. Gruss, B. Maro and M. -H. Verlhac. (2008). Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. PLoS One. 3:e3338.
    PMID: 18833336
  • Brouhard, G. J., J. H. Stear, T. L. Noetzel, J. Al-Bassam, K. Kinoshita, S. C. Harrison, J. Howard and A. A. Hyman. (2008). XMAP215 is a processive microtubule polymerase. Cell. 132:79-88.
    PMID: 18191222
  • Mori, D., Y. Yano, K. Toyo-oka, N. Yoshida, M. Yamada, M. Muramatsu, D. Zhang, H. Saya, Y. Y. Toyoshima, K. Kinoshita, A. Wynshaw-Boris and S. Hirotsune. (2007). NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation and TACC3 recruitment. Mol Cell Biol. 27:352-367.
    PMID: 17060449
  • Aoki, K., Y. Nakaseko, K. Kinoshita, G. Goshima and M. Yanagida. (2006). Cdc2 phosphorylation of the fission yeast Dis1 ensures accurate chromosome segregation. Curr Biol. 16:1627-1635.
    PMID: 16920624
  • Kinoshita, K., T. L. Noetzel, I. Arnal, D. N. Drechsel and A. A. Hyman. (2006). Global and local control of the microtubule destabilizing activity of a catastrophe kinesin MCAK/XKCM1. J Muscle Res Cell Motil. 27:107-114.
    PMID: 16450057
  • Kinoshita, K., T. L. Noetzel, L. Pelletier, K. Mechtler, D. N. Drechsel, A. Schwager, M. Lee, J. W. Raff and A. A. Hyman. (2005). Aurora A phosphorylation of TACC3/Maskin is required for centrosome-dependent microtubule assembly in mitosis. J Cell Biol. 170:1047-1055.
    PMID: 16172205
  • Barros, T. P., K. Kinoshita, A. Hyman and J. W. Raff. (2005). Aurora A kinase activates D-TACC/Msps complexes exclusively at centrosomes during mitosis to stabilise astral microtubules. J Cell Biol. 170:1039-1046.
    PMID: 16186253
  • Özlü, N., M. Srayko, K. Kinoshita, B. Habermann, E. T. O’ Toole, T. Müller-Reichert, N. Schmalz, A. Desai and A. A. Hyman. (2005). An essential function of the C. elegans ortholog of TPX2 is to localize activated Aurora A kinase to mitotic spindles. Dev Cell. 9:237-248.
    PMID: 16054030
  • Noetzel, T. L., D. N. Drechsel, A. A. Hyman and K. Kinoshita. (2005). A comparison of the ability of XMAP215 and tau to inhibit the microtubule destabilizing activity of XKCM1. Philos Trans R Soc Lond B Biol Sci. 360:591-594.
    PMID: 15905143
  • Schaar, B. T., K. Kinoshita and S. K. McConnell. (2004). Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron. 41:203-213.
    PMID: 14741102
  • Kinoshita, K., B. Habermann and A. A. Hyman. (2002). XMAP215: a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol. 12:267-273.
    PMID: 12074886
  • Kinoshita, K., I. Arnal, A. Desai, D. N. Drechsel and A. A. Hyman. (2001). Reconstitution of physiological microtubule dynamics using purified components. Science. 294:1340-1343.
    PMID: 11701928
  • Popov, A. V., A. Pozniakovsky, I. Arnal, C. Antony, A. J. Ashford, K. Kinoshita, R. Tournebize, A. A. Hyman and E. Karsenti. (2001). XMAP215 regulates microtubule dynamics through two distinct domains. EMBO J. 20:397-410.
    PMID: 11157747
  • Zumbrunn, J., K. Kinoshita, A. A. Hyman and I. S. Nathke. (2001). Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol. 11:44-49.
    PMID: 11166179
  • Tatebe, H., G. Goshima, K. Takeda, T. Nakagawa, K. Kinoshita and M. Yanagida. (2001). Fission yeast living mitosis visualized by GFP-tagged gene products. Micron. 32:67-74.
    PMID: 10900382
  • Tournebize, R., A. Popov, K. Kinoshita, A. J. Ashford, S. Rybina, A. Pozniakovsky, T. U. Mayer, C. E. Walczak, E. Karsenti and A. A. Hyman. (2000). Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat Cell Biol. 2:13-19.
    PMID: 10620801
  • Nakaseko, Y., K. Nabeshima, K. Kinoshita and M. Yanagida. (1996). Dissection of fission yeast microtubule associating protein p93Dis1: regions implicated in localization and microtubule interaction. Genes Cells. 1:633-644.
    PMID: 9078390
  • Kinoshita, K., T. Nemoto, K. Nabeshima, H. Kondoh, H. Niwa and M. Yanagida. (1996). The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morophogenesis, cell wall synthesis and cytokinesis. Genes Cells. 1:29-45.
    PMID: 9078365
  • Nabeshima, K., H. Kurooka, M. Takeuchi, K. Kinoshita, Y. Nakaseko and M. Yanagida. (1995). p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites. Genes Dev. 9:1572-1585.
    PMID: 7628693

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Chromosome Dynamics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
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