Seeking (a) Research Scientist or Senior Research Scientist(IMS505-1801)

Research Field

Outline of research: Target identification leading to successful development of therapeutic modalities for poor prognosis human malignancies with emphasis on hematopoietic malignancies, through cell biology, patient-derived xenotransplantation models, genomic/epigenomic approaches and bioinformatic analyses.

Research topics to be assigned: Identification of effective targets in human malignancies focusing on clonal analyses; Identification of small molecules and other therapeutic agents for preclinical and clinical development.

The Laboratory for Human Disease Models has pioneered the development of the humanized mouse through xenotransplantation of normal and diseased human hematopoietic stem cells into newborn immune-deficient NOD/SCID/IL2Rg-null (NSG) mice. Through ongoing collaboration with Toranomon Hospital, with one of the largest hematology/oncology divisions in Japan, we have obtained samples from nearly 400 patients with hematologic malignancies and created PDX models for acute myeloid leukemia, chronic myeloid leukemia and acute lymphoblastic leukemia. Through collaborations with medicinal chemists and structural biologists within RIKEN.

Selected publications:
-Saito Y et al, A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo, Science Translational Medicine 5, 181ra52, 2013.
-Saito Y et al, Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML, Nature Biotechnology 28, 275-280, 2010.
-Saito Y et al, Identification for therapeutic targets for quiescent chemotherapy-resistant human AML stem cells, Science Translational Medicine 2, 17ra9, 2010.
-Ishikawa F, Chemotherapy-resistant human AML stem cells home to and engraft within the bone marrow endosteal region, Nature Biotechnology 25, 1315-1321, 2007. For details, see: Laboratory for Human Disease Models

Job title and Job description


Research Scientist or Senior Research Scientist

Number of openings

Two openings.

Job descriptions

The Laboratory for Human Disease Models at RIKEN Center for Integrative Medical Sciences (IMS) seeks innovative scientists for a Research Scientist or Senior Research Scientist position, to pursue basic and translational research with emphasis on analysis of human hematopoiesis and hematopoietic malignancies. This newly created position is a part of interdisciplinary project to find novel effective targets and therapeutic strategies against poor prognosis malignancies with special focus on hematologic malignancies, supported by RIKEN President and led by the Laboratory for Human Disease Models (PI: Fumihiko Ishikawa, MD/PhD).

Desired interests include: Human hematopoiesis and malignancies, single-cell approaches with applications to genomics, epigenetics, cell biology and clinical problem solving and computational/systems/quantitative technology development. Strong interest in development of novel therapeutic agents and expertise in genomic science or leukemia research are highly desirable. Candidates will have a doctoral-level degree, outstanding skills in collaborative, interdisciplinary research and the potential to move projects forward independently under supervision of the laboratory head. The candidate will work in close collaborative relationship with investigators of other laboratories at RIKEN.

Position-specific tasks are as follows

*Senior Scientists: Assist Group Directors, Team Leaders or the Platform Unit Leader and carry out research topics, etc. while instructing Research Scientists and the like in their Research Group, etc.
*Research Scientist: Carries out research and other work in accordance with team research themes.


  • Please see “Job title and Job description.”
  • Doctoral-level degree in the relevant research field.
  • Must have good communication skills and be able to engage in the research in a coordinated manner.

Work location

RIKEN Center for Integrative Medical Sciences
1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0045 Japan

Salary and benefits

Terms of contract

  1. A one-year fixed-term employment contract, renewable based on evaluation, until March 31, 2023 (the scheduled completion date for the project written in “Job Descriptions”).
  2. RIKEN may adjust the above maximum period of renewability based on a) the employee’s abilities, work load at the time of contract completion, performance and work attitude and b) the continuation of the employee’s center, laboratory or project and RIKEN’s management situation and budget at the time. In principle, employment contracts will not be renewed for individuals older than 65 years.
  3. The employee’s period of fixed-term employment cannot exceed 10 years from the initial date of hire (or 10 years from April 1, 2013 for fixed-term employees already at RIKEN prior to this date).


Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Social insurance will be applied. Mandatory membership in the RIKEN Mutual Benefit Society (RIKEN Kyosaikai).


Days off include public holidays, New Year's holidays (Dec. 29 - Jan 3), and RIKEN Foundation Day.

Other provisions

Other provisions are in accordance with RIKEN regulations.

* RIKEN is promoting a Gender Equity Program by taking various measures to create a workplace where both men and women are able to give full rein to their talents and abilities. When applicants are judged to be equally qualified on the basis of fair and impartial criteria, women applicants will be given preference.
* Also, eligible for an exemption from repayment for category 1 scholarship loans provided by the Japan Student Services Organization before fiscal year 2003, and eligible applying for the MEXT Grants-in-Aid for Scientific Research (Kakenhi).

Application and required documents

Please provide the documents indicated below as PDF files and send them to the email address indicated in [Contact Information].
* Please write "Application Documents; (IMS505-1801)Human Disease Models, Research Scientist or Senior Research Scientist(your applying job title)" in the subject line.

Documents to submit


  1. CV with photograph and Email address.
    *Please indicate the open call ID [IMS505-1801] in the upper right corner of the CV.
    *Using the RIKEN format above is appreciated. WORD(56KB) EXCEL(159KB)
  2. List of publications (articles, reviews and books), presentations, etc. in past 5 years.
  3. Brief description of previous research and achievements, and future research plans (within two A4-size pages).
  4. Recommendation Letter (1): (The desired laboratory, position title and contact information for the recommending person must be included.
    *If it is difficult to obtain a recommendation letter from the current supervisor, a recommendation from a third party will be accepted.) The letter of recommendation should be addressed to the “Director of the RIKEN Center for Integrative Medical Sciences.”
    *If the person providing the recommendation will send the letter directly, please send it to the address indicated in [Inquiries / Contact Information] below.
  5. Certificate of graduation, copy of diploma for highest degree (photocopy acceptable) or official letter of impending graduation.
    *This document can be sent anytime up until the day of final interview.
  6. List of competitive external funds obtained (e.g. Grants-in-Aid for Scientific Research [KAKENHI]; indicate whether you are the representative researcher or the collaborator)

Note:Application documents will not be returned.


Position will be closed after a suitable candidate is found.

Handling Personal Data

Handling of Personal Data: All private data sent to RIKEN in application for employment is handled in strict confidentiality, and such data is not utilized for any other purpose or disclosed to any third party. Application documents will not be returned.

Selection process

After the document screening, successful applicants will be interviewed.

Start of Employment

May 1st, 2018 or later. (negotiable).

Contact Information

Any questions about this position should be sent to the email address given below.
Please write "Open call IMS505-1801 Laboratory for Human Disease Models, IMS" in the subject line.

For application documents and general questions:
Recruiting staff for RIKEN Center for Integrative Medical Sciences
Administrative Division, RIKEN Yokohama Branch
(please change [at] to @ to complete address)

For research contents:
Laboratory for Human Disease Models,
RIKEN Center for Integrative Medical Sciences
Team Leader: Fumihiko Ishikawa (M.D., Ph.D)
(please change [at] to @ to complete address)