RIKEN Center for Biosystems Dynamics Research Laboratory for Cell Signaling Dynamics
Team Leader: Masahiro Ueda (Ph.D.)
Research Summary
Our group studies how signal transduction function of living cells arises spontaneously from the dynamics of intracellular reaction networks (design principles), and the mechanisms that allow these systems to process signals under the strong influence of thermal and stochastic noise (computation principles). As a typical example of stochastic biomolecular computation in living cells, we specifically focus on the gradient sensing and directional cell migration seen in the cellular slime mold Dictyostelium discoideum. In this research project, by combining advanced imaging techniques including single-molecule detection with theoretical modeling, we aim to better understand these two principles while at the same time develop the techniques necessary to do so.
Main Research Fields
- Biology
Related Research Fields
- Mathematical & Physical Sciences
- Medicine, Dentistry & Pharmacy
Keywords
- Nanobiology
- Cell signaling
- Bioimaging
- Mathematical modeling
- Optical microscopy
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.Kamimura, Y., Miyanaga, Y. & Ueda, M.
"Heterotrimeric G protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis.",
Proc. Natl. Acad. Sci. USA., 113: 4356-4361 (2016). - 2.Komatsuzaki, A., Ohyanagi, T., Tsukasaki, Y., Miyanaga, Y., Ueda, M. & Jin, T.:
"Compact Halo-Ligand-Conjugated Quantum Dots for Multicolored Single-Molecule Imaging of Overcrowding GPCR Proteins on Cell Membranes"
Small 11, 1396-1401 (2015) - 3.Yasui, M., Matsuoka, S. & Ueda, M.:
"PTEN Hopping on the Cell Membrane Is Regulated via a Positively-Charged C2 Domain"
PLoS Comput. Biol. 10 (2014) - 4.Cai, H., Katoh-Kurasawa, M., Muramoto, T., Santhanam, B., Long, Y., et al.:
"Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer"
Science 343, 1329-+ (2014) - 5.Nishikawa, M., Horning, M., Ueda, M. & Shibata, T.:
"Excitable Signal Transduction Induces Both Spontaneous and Directional Cell Asymmetries in the Phosphatidylinositol Lipid Signaling System for Eukaryotic Chemotaxis"
Biophys. J. 106, 723-734 (2014) - 6.Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., et al.:
"TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding"
Nat. Neurosci. 16, 1556-1566 (2013) - 7.Matsuoka, S., Shibata, T. & Ueda, M.:
"Asymmetric PTEN Distribution Regulated by Spatial Heterogeneity in Membrane-Binding State Transitions"
PLoS Comput. Biol. 9 (2013) - 8.Nishimura, S. I., Ueda, M. & Sasai, M.:
"Non-Brownian dynamics and strategy of amoeboid cell locomotion"
Phys. Rev. E 85 (2012) - 9.Tsujioka, M., Yumura, S., Inouye, K., Patel, H., Ueda, M. & Yonemura, S.:
"Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis "
Proc. Natl. Acad. Sci. U.S.A. 109, 12992-12997 (2012) - 10.*Arai, Y., Shibata, T., Matsuoka, S., Sato, M. J., Yanagida, T. & Ueda, M.:
"Self-organization of the phosphatidylinositol lipids signaling system for random cell migration"
Proc. Natl. Acad. Sci. U.S.A. 107, 12399-12404 (2010)
Recent Research Results
Related Links
Lab Members
Principal investigator
- Masahiro Ueda
- Team Leader
Core members
- Michio Hiroshima
- Senior Scientist
- Yoichiro Kamimura
- Senior Scientist
- Satomi Matsuoka
- Research Scientist
- Jun Kozuka
- Research Scientist
- Masato Yasui
- Postdoctoral Researcher
- Hiroyasu Koteishi
- Postdoctoral Researcher
- Kazutoshi Takebayashi
- Junior Research Associate
- Daisuke Yoshioka
- Junior Research Associate
- Hidenori Hashimura
- Junior Research Associate
- Kaori Tanabe
- Technical Staff I
- Sizuka Taguchi
- Technical Staff I
- Akiko Kanayama
- Technical Staff I
Contact Information
Email: masahiroueda [at] riken.jp