Centers & Labs

RIKEN Brain Science Institute

Laboratory for Local Neuronal Circuits

Laboratory Head: Toshihiko Hosoya (Ph.D.)
Toshihiko  Hosoya(Ph.D.)

The long-term goal of Hosoya Laboratory is to understand brain functions by investigating local neuronal circuits. The group has two strategies: analyzing simple circuits, and decomposing complex circuits into simpler subcircuits. The model system for the first strategy is the vertebrate retina, with which precise analysis of input/output relationship is possible. Results show that the retinal coding rule is adaptively modified according to the correlations in the visual input, and that single neurons encode multiple quantities with precise temporal patterns of spikes. The target of the second strategy is the local circuit of the mammalian neocortex. Novel microstructures have been identified in Hosoya Laboratory using genetic techniques, and functional analyses are now underway.

Selected Publications

  1. Maruoka H, Kubota K, Kurokawa R, Tsuruno S and Hosoya T.:
    " Periodic organization of a major subtype of pyramidal neurons in neocortical layer V."
    The Journal Neuroscience, 31(50), 18522-18542 (2011)
  2. Oizumi M, Ishii T, Ishibashi K, Hosoya T and Okada M.:
    " Mismatched decoding in the brain."
    The Journal Neuroscience, 30(13), 4815-4826 (2010)
  3. Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, Hosoya T, Higashijima S and Okamoto H.:
    " The habenula is crucial for experience-dependent modification of fear responses in zebrafish."
    Nature Neuroscience, 13(11), 1354-1356 (2010)
  4. Lesica NA, Ishii T, Stanley GB and Hosoya T.:
    " Estimating receptive fields from responses to natural stimuli with asymmetric intensity distributions."
    PLoS ONE. 3(8), e3060 (2008).
  5. Kaneda M, Ishii T and Hosoya T.:
    " Pathway-dependent modulation by P2-purinoceptors in the mouse retina."
    Eur J Neurosci. 28(1), 128-36 (2008).
  6. Hosoya T, Baccus S.A and Meister M.:
    " Dynamic predictive coding by the retina."
    Nature, 436(7047), 1971-77 (2005).
  7. Akiyama Y, Hosoya T, Poole AM and Hotta Y.:
    " The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals."
    Proc Natl Acad Sci USA, 93(25), 14912-6(1996)
  8. Hosoya T, Takizawa K, Nitta K and Hotta Y.:
    " Glial cells missing: a binary switch between neuronal and glial determination in Drosophila."
    Cell, 82(6), 1025-36 (1995).

Lab Members

Principal Investigator

Toshihiko Hosoya
Laboratory Head

Core Members

Hisato Maruoka
Research Scientist
Nao Nakagawa
Research Scientist
Taisuke Yoneda
Research Scientist
Eriko Oshima
Technical Staff I
Miyuki Kishino
Technical Staff I

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: hosoya [at]

Related links

Recent research results