Centers & Labs

RIKEN Brain Science Institute

Laboratory for Neuronal Growth Mechanisms

Laboratory Head: Hiroyuki Kamiguchi (M.D., Ph.D.)
Hiroyuki  Kamiguchi(M.D., Ph.D.)

The development of functional neuronal networks relies on the spatial accuracy of axon extension. Each extending axon is tipped by a growth cone that can interpret extracellular "guidance cues" and navigate the axon along the correct path. After neuronal networks have been developed, injury to the adult central nervous system induces the formation of barriers to regenerating axons. It is well known that growth cones use similar mechanisms for their navigation during development and regeneration. Our aim is to investigate growth cone navigation with particular emphasis on the roles of guidance cues, intracellular signals, cytoskeleton, adhesion machinery and membrane dynamics. These revelations will help elucidate the fundamental principles of axon tract formation and establish the molecular and cellular biological basis for axon tract repair.

Main Research Field

Biological Sciences

Related Research Fields

Medicine, dentistry, and pharmacy

Keywords

  • neural regeneration
  • axon guidance

Selected Publications

  1. Akiyama H, Fukuda T, Tojima T, Nikolaev VO, and Kamiguchi H:
    "Cyclic nucleotide control of microtubule dynamics for axon guidance."
    The Journal of Neuroscience, 36(20), 5636-5649 (2016)
  2. Wada F, Nakata A, Tatsu Y, Ooashi N, Fukuda T, Nabetani T, and Kamiguchi H:
    "Myosin Va and endoplasmic reticulum calcium channel complex regulates membrane export during axon guidance."
    Cell Reports, 15(6), 1329-1344 (2016)
  3. Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, and Kamiguchi H:
    "Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord."
    Science, 349(6251), 974-977 (2015)
  4. Tojima T, Itofusa R, and Kamiguchi H:
    "Steering Neuronal Growth Cones by Shifting the Imbalance between Exocytosis and Endocytosis."
    The Journal of Neuroscience, 34(21), 7165-78 (2014)
  5. Tojima T, Hines JH, Henley JR, and Kamiguchi H:
    "Second messengers and membrane trafficking direct and organize growth cone steering."
    Nature Reviews Neuroscience 12(4), 191-203 (2011)
  6. Akiyama H, and Kamiguchi H:
    "Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance."
    The Journal of Biological Chemistry 285(53), 41740-41748 (2010)
  7. Tojima T, Itofusa R, and Kamiguchi H:
    "Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance."
    Neuron 66(3), 370-377 (2010)
  8. Tamada A, Kawase S, Murakami F, and Kamiguchi H:
    "Autonomous right-screw rotation of growth cone filopodia drives neurite turning."
    The Journal of Cell Biology 188(3), 429-441(2010)
  9. Akiyama H, Matsu-ura T, Mikoshiba K, and Kamiguchi H:
    "Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals."
    Science Signaling 2(79), ra34 (2009)
  10. Tojima T, Akiyama H, Itofusa R, Li Y, Katayama H, Miyawaki A, and Kamiguchi H:
    "Attractive axon guidance involves asymmetric membrane transport and exocytosis in the growth cone."
    Nature Neuroscience 10(1), 58-66 (2007)

Lab Members

Principal Investigator

Hiroyuki Kamiguchi
Laboratory Head

Core Members

Adam Tsuda Guy
Research Scientist
Carmen Chan
Research Scientist
Tomonobu Hida
Research Scientist
Mariko Inoue
Technical Staff I
Noriko Ooashi
Technical Staff I
Tetsuko Fukuda
Technical Staff I
Asuka Nakata
Technical Staff I
Hiromu Ito
Technical Staff I
Marianne Demailly
International Program Associate
Natsuko Matshzaki
Technical Staff I

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: kamiguchi [at] brain.riken.jp

Related links

Recent research results