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RIKEN Center for Brain Science Laboratory for Neurodiversity

Laboratory Head: Adrian Walton Moore (Ph.D.)

Research Summary

Adrian Walton Moore

The long term aim of our lab is to understand the regulatory control systems that guide neuron differentiation and morphogenesis. With this plan, we aim to reveal fundamental molecular mechanisms that create form and function in the nervous system. Our research will also contribute to explaining the dysregulated mechanisms that cause neurodevelopmental disorders, and it can suggest ways we can reawaken the neuron differentiation program for neuronal repair. Please see our lab website to find out more about our research, and lab life.

Main Research Fields

  • Biological Sciences

Related Research Fields

  • Interdisciplinary Science & Engineering
  • Biology
  • Medicine, Dentistry & Pharmacy
  • Neuroscience-general-related
  • Cell biology-related
  • Developmental biology-related

Keywords

  • neuron differentiation
  • dendrite and axon
  • neural stem cells
  • microtubules
  • in vivo cell imaging

Selected Publications

  • 1. Suzuki T., Tatsukawa T., Sudo G., Delandre C., Pai YJ., Miyamoto H., Raveau M., Shimohata A., Ohmori I., Hamano S., Haginoya K., Uematsu M., Takahashi Y., Morimoto M., Fujimoto S., Osaka H., Oguni H., Osawa M., Ishii A., Hirose S., Kaneko S., Inoue Y., Moore AW., Yamakawa K.
    "CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainite"
    Scientific Reports 12, e6505. (2022).
  • 2. Pai YJ., Moore AW.
    "Transcription factor encoding of neuron subtype: strategies that specify arbor pattern"
    Curr. Opin. Neurobiol. 69, pp149-158. (2021).
  • 3. Yoong LF., Lim HK., Tran H., Lackner S., Zheng Z., Hong P., Moore AW.
    "Atypical myosin tunes dendrite arbor subdivision"
    Neuron 106, pp452-467. (2020).
  • 4. Rives-Quinto N., Komori N., Ostgaard CM., Janssens DH., Kondo S., Dai Q., Moore AW., Lee CY.
    "Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes"
    Elife 9, e56187. (2020).
  • 5. Liang X., Kokes M., Fetter RD., Sallee MD., Moore AW., Feldman JL., Shen K.
    "Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites"
    Elife 9, e56547. (2020).
  • 6. Wilkes OR., Moore AW.
    "Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity"
    Front. Cell. Neurosci. 14, e398. (2020).
  • 7. Urun FR., Moore AW.
    "Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration"
    Cells 9, e2112. (2020).
  • 8. Chen YC., Auer-Grumbach M., Matsukawa S., Zitzelsberger M., Themistocleous AC., Strom TM., Samara C., Moore AW., Cho LT., Young GT., Weiss C., Schabhüttl M., Stucka R., Schmid AB., Parman Y., Graul-Neumann L., Heinritz W., Passarge E., Watson RM., Hertz JM., Moog U., Baumgartner M., Valente EM., Pereira D., Restrepo CM., Katona I., Dusl M., Stendel C., Wieland T., Stafford F., Reimann F., von Au K., Finke C., Willems PJ., Nahorski MS., Shaikh SS., Carvalho OP., Nicholas AK., Karbani G., McAleer MA., Cilio MR., McHugh JC., Murphy SM., Irvine AD., Jensen UB., Windhager R., Weis J., Bergmann C., Rautenstrauss B., Baets J., De Jonghe P., Reilly MM., Kropatsch R., Kurth I., Chrast R., Michiue T., Bennett DL., Woods CG., Senderek J.
    "Transcriptional regulator PRDM12 is essential for human pain perception"
    Nat. Genet. 7, pp803-8. (2015)
  • 9. Yalgin C., Ebrahimi S., Delandre C., Yoong LF., Akimoto S., Tran H., Amikura R., Spokony R., Torben-Nielsen B., White KP., Moore AW.
    "Centrosomin represses dendrite branching by orienting microtubule nucleation"
    Nat. Neurosci. 18, pp1437-45. (2015).
  • 10. Endo K., Karim MR., Taniguchi H., Krejci A., Kinameri E., Siebert M., Ito K., Bray S., Moore AW.
    "Chromatin modification of Notch targets in olfactory receptor neuron diversification"
    Nat. Neurosci. 15, pp224-33. (2012).

Recent Research Results

Related Links

Lab Members

Principal investigator

Adrian Walton Moore
Laboratory Head

Core members

Fatma Rabia Urun
Postdoctoral Researcher
Yong You Jason Tann
Postdoctoral Researcher
Cecilia Benazzato
Postdoctoral Researcher
Fangke Xu
Special Postdoctoral Researcher
Minami Kimura
Technical Staff I

Careers

Position Deadline
Postdoctoral Researcher Position (W23279) Open until filled
Technical Staff Position (W23274) Open until filled

Contact Information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Email: adrian.moore [at] riken.jp

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