Centers & Labs

RIKEN Center for Developmental Biology

Laboratory for Axial Pattern Dynamics

Team Leader: Hidehiko Inomata (Ph.D.)
Hidehiko  Inomata(Ph.D.)

Developmental processes take place through the exchange of information by cells within the constrained spatial environment of the embryo. Such intercellular communication is mainly regulated by a morphogen gradient. In order to ensure that development based on a simple morphogen gradient is stably reproducible, cell-cell communications mediated by morphogens need to be robust against perturbations. In our lab, we address the analysis of morphogen dynamics and extracellular fluid dynamics to study how developmental robustness is maintained. We are also working to develop methods for controlling the shape of morphogen gradients to spatiotemporally regulate the morphogen-dependent pattern formations.

Main Research Field

Biology

Related Research Fields

Mathematical and physical sciences / Biology

Keywords

  • Embryogenesis
  • Morphogen gradient
  • Fluid dynamics
  • Pattern formation

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. H. Inomata, T. Shibata, T. Haraguchi and Y. Sasai:
    "Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals."
    Cell 153.1296-311 (2013)
  2. D. Kamiya, S. Banno, N.Sasai, M. Ohgushi, H. Inomata, K. Watanabe, M. Kawada, R. Yakura, H. Kiyonari, K. Nakao, LM. Jakt, S. Nishikawa and Y. Sasai:
    "Intrinsic transition of embryonic stem-cell differentiation into neural progenitors."
    Nature 470.503-9 (2011)
  3. A. Takai, H. Inomata, A. Arakawa, R. Yakura, M. Matsuo-Takasaki and Y. Sasai:
    "Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway."
    Development 137.3293-302 (2010)
  4. H. Inomata, T. Haraguchi and Y. Sasai:
    "Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation."
    Cell 134.854-65 (2008)
  5. A.Arakawa, M. Matsuo-Takasaki, A. Takai, H. Inomata, M. Matsumura, M. Ikeya, K. Takahashi, Y. Miyachi, N. Sasai and Y. Sasai:
    "The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo."
    Dev Biol 306.160-9 (2007)
  6. T. Onai, M. Matsuo-Takasaki, H. Inomata, T. Aramaki, M. Matsumura, R. Yakura, N. Sasai and Y. Sasai:
    "XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination."
    EMBO J 26.2350-60 (2007)
  7. *H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa and N. Kitamura:
    "A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1."
    J Biol Chem 278.22946-55 (2003)

Lab Members

Principal Investigator

Hidehiko Inomata
Team Leader

Core Members

Shinya Matsukawa
Research Scientist
Kaori Niimi
Technical Staff I
Setsuko Kanamura
Technical Staff I

Contact information

4F, RIKEN CDB Bldg.C,
2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan

Email: hideino [at] cdb.riken.jp

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