Centers & Labs

RIKEN Center for Developmental Biology

Laboratory for in vitro Histogenesis

Team Leader: Mototsugu Eiraku (Ph.D.)
Mototsugu  Eiraku(Ph.D.)

In vitro generation of a functional organ with complex structures is one major goal for the field of developmental and cell biology. To achieve this goal, it is a reasonable strategy to recapitulate the ontogeny, which is the most efficient and robust process for organogenesis that has been acquired through evolution, in an in vitro system. Our laboratory aims to clarify the molecular and cellular dynamics underlying organogenesis, and to develop new technologies for in vitro recapitulation, that is, three-dimensional functional organ formation from stem cells. These researches aim to make important contributions to the field of developmental biology, stem cell biology, and regenerative medicine.

Main Research Field


Related Research Fields

Biological Sciences


  • Tissue formation
  • Self-organization
  • Stem cells
  • Regenerative medicine

Selected Publications

  1. Hasegawa Y, et al.:
    "Emergence of dorsal-ventral polarity in ESC-derived retinal tissue."
    Development 143 (21), 3895-3906 (2016)
  2. Sakaguchi H, et al.:
    "Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue."
    Nat Commun 6, 8896 (2015)
  3. Kuwahara A, et al.:
    "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue."
    Nat Commun 6. 6286 (2015)
  4. Okuda S, et al.:
    "Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis."
    Biomech Model Mechanobiol 14.413-25 (2015)
  5. Kadoshima T, et al.:
    "Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human E cell-derived neocortex."
    Proc Natl Acad Sci U S A 110. 20284-9 (2013)
  6. Nakano T, et al.:
    "Self-formation of optic cup and storable stratified neural retina from human ESCs."
    Cell Stem Cell 10. 771-85 (2012)
  7. Eiraku M, et al.
    "Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems."
    Bioessays 34. 17-25 (2012)

Lab Members

Principal Investigator

Mototsugu Eiraku
Team Leader

Core Members

Masatoshi Ohgushi
Senior Scientist
Shunsuke Mori
Research Scientist
Satoru Okuda
Special Postdoctoral Researcher
Masako Kawada
Technical Staff II
Eriko Sakakura
Technical Staff II

Contact information

2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan

Email: eiraku [at]

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