Centers & Labs

RIKEN Center for Developmental Biology

Laboratory for Growth Control Signaling

Team Leader: Takashi Nishimura (Ph.D.)
Takashi  Nishimura(Ph.D.)

The processes of animal development, including organ size and body size, are genetically predetermined, but these processes are also influenced by environmental factors such as nutrition and temperature. The close link between cell and tissue growth control and environmental cues ensures that developmental transitions occur at the appropriate time during animal development.

Cell proliferation and differentiation in each tissue and organ are kept under strict regulation, both spatially and temporally. Research has revealed the nature of spatial signals, such as growth factors and morphogens, but the way in which these signals direct cell and tissue growth over time remains understood. In addition, growth and developmental timing are also governed by nutrient availability. Most species have a standard body size, but developing organisms are also capable of adapting their growth to fluctuating nutritional states through metabolic regulation. Therefore, linking the nutrient-sensing system to an endocrine signaling network allows organisms to control the timing of cell proliferation and differentiation.

Our team’s research aims to shed light on the molecular basis for growth control and developmental timing at the cellular and tissue/organ level using Drosophila as a model system. In particular, we are interested in addressing the following questions: 1) how do organisms adapt their growth program to changes in energy needs and states; 2) what are the molecular mechanisms that sense nutrient availability and regulate body size; and 3) how do endocrine signals interact with metabolic and growth regulators?

To better understand the interface between nutrient availability and growth regulation, we are focusing on how nutrition controls systemic growth through Drosophila insulin-like peptides (Dilps). Members of the insulin family of peptides have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans. We are now analyzing the molecular mechanism underlying the nutrient-dependent expression of Dilp genes. We have also conducted in vivo RNAi screening to identify new players regulating growth and developmental timing at the organismal level. We described the first demonstration of the glia-derived endocrine factor regulating systemic body growth. The identification of SDR protein in Drosophila provides a new concept for the regulation of insulin/IGF signaling.

Main Research Field


Related Research Fields

Biological Sciences


  • Growth control
  • Insulin/IGF
  • Metabolism

Selected Publications

  1. Yasugi T, et al.:
    "Adaptation to dietary conditions by trehalose metabolism in Drosophila."
    Sci Rep 7.1619 (2017)
  2. Yoshida M, et al.:
    "Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis."
    Sci Rep 6.30582 (2016)
  3. Okamoto N, et al.:
    "Signaling from glia and cholinergic neurons controls nutrient-dependent production of an insulin-like peptide for Drosophila body growth."
    Dev Cell 35.295-310 (2015)
  4. Matsuda H, et al.:
    "Flies without Trehalose."
    J Biol Chem 290.1244-55 (2015)
  5. Okamoto N, et al.:
    "A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila."
    Genes Dev 27.87-97 (2013)
  6. Okamoto N, et al.:
    "Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression."
    Proc Natl Acad Sci USA 109.2406-11 (2012)

Lab Members

Principal Investigator

Takashi Nishimura
Team Leader

Core Members

Kota Banzai
Research Scientist
Masako Mino
Research Associate
Takayuki Yamada
Technical Staff I

Contact information

7F, RIKEN CDB Bldg.A, 2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan

Email: t-nishimura [at]

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