Centers & Labs

Chief Scientist Laboratories

Bioengineering Laboratory

Chief Scientist: Mizuo Maeda (D.Eng.)
Mizuo  Maeda(D.Eng.)

The principal purpose of the laboratory is to explore a new frontier of research field which fuses engineering and biological science. On the basis of polymer chemistry, analytical chemistry, surface chemistry, biochemistry and molecular biology, we are studying on new materials comprising biological components, novel methodology for bioanalysis and medical diagnosis, and artificial systems for regulation of biological processes. Those new ideas and materials are being applied to the field of biomaterials science, environmental science, micro/nanoscience, life science and medical engineering. For example, we newly prepared DNA-vinyl polymer conjugates which have been applied for DNA biosensor, affinity electrophoresis, SNPs-responsive diagnostic nanoparticle, gene-responsive hydrogel, artificial gene regulation system, etc. These researches may be classified into a new category, i.e., "DNA engineering".

Main Research Field

Engineering

Related Research Fields

Chemistry / Materials Sciences / Biology & Biochemistry / Microbiology / Environment & Ecology / Multidisciplinary

Research Subjects

  • DNA Conjugate Chemistry
  • Bioanalytical Systems Engineering
  • Biomacromolecular Science

Selected Publications

  1. Fujita,M., Hiramine, H., Pan, P., Hikima, T., and Maeda, M.:
    "Effects of Complementary DNA and Salt on the Thermoresponsiveness of Poly(N-isopropylacrylamide)-b-DNA"
    Langmuir, in press.
  2. Kondo, E., Wada, K., Hosokawa, K.,, and Maeda, M.:
    "Cryopreservation of adhered mammalian cells on a microfluidic device: toward ready-to-use cell-based experimental platforms"
    Biotechnol. & Bioeng., 113, 237-240 (2016).
  3. Wang, G., Akiyama, Y., Takarada, T., and Maeda, M.:
    "Rapid Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanorods and Nanotriangles for Colorimetric Single-Nucleotide Discrimination"
    Chem. Eur. J. 22, 258-263 (2016).
  4. Ma, C., Pan, P., Shan, G., Bao, Y., Fujita, M., and Maeda, M.:
    "Core-Shell Structure, Biodegradation, and Drug Release Behavior of Poly(lactic acid)/Poly(ethylene glycol) Block Copolymer Micelles Tuned by Macromolecular Stereostructure"
    Langmuir, 31, 1527-1536 (2015).
  5. Ishihara, R., Hasegawa, K., Hosokawa, K., and Maeda, M.:
    "Multiplex microRNA detection on a power-free microfluidic chip with laminar flow-assisted dendritic amplification"
    Anal. Sci., 31, 573-576 (2015).
  6. Hiraishi, T., Abe H., and Maeda, M.:
    "Substrate stereoselectivity of poly(Asp) hydrolase-1 capable of cleaving β-amide bonds as revealed by investigation of enzymatic hydrolysis of stereoisomeric β-tri(Asp)s"
    AMB Express, 5, 31 (2015).
  7. Akiyama, Y., Shikagawa, H., Kanayama, N., Takarada, T., and Maeda, M.:
    "Modulation of Interparticle Distance in Discrete Gold Nanoparticle Dimers and Trimers by DNA Single-Base Pairing"
    Small 11, 3153-3161 (2015).
  8. Ozasa, K., Lee, J., Song, S., Hara, M., and Maeda, M.:
    "Autonomous Pattern Formation of Micro-organic Cell Density with Optical Interlink between Two Isolated Culture Dishes"
    Artif. Life, 21, 234-246 (2015).
  9. Zhu, B., Luo, S., Zhao, H., Lin, H,. Sekine, J., Nakao, A., Chen, C., Yamashita, Y. and Yu, H.:
    "Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer"
    Nat. Comm., 5, 4523 (2014).
  10. Kanayama, N., Takarada, T., Fujita, M., and Maeda, M.:
    "DNA Terminal Breathing Regulated by Metal Ions for Colloidal Logic Gates"
    Chem. Eur. J. 19, 10794-10798 (2013).

Lab Members

Principal Investigator

Mizuo Maeda
Chief Scientist

Core Members

Kazunari Ozasa
Senior Research Scientist
Aiko Nakao
Senior Research Scientist
Tomohiro Hiraishi
Senior Research Scientist
Akiko Yamaji
Senior Research Scientist
Kazuo Hosokawa
Senior Research Scientist
Masahiro Fujita
Senior Research Scientist
Tohru Takarada
Senior Research Scientist
Guoqing Wang
Postdoctoral Researcher
Young-Jin Kim
Postdoctoral Researcher
Ken-Ichi Wada
Contract Researcher
Kazuki Hasegawa
Junior Research Associate
Shota Shiraishi
Student Trainee
Nana Shinohara
Student Trainee
Takafumi Sako
Student Trainee
Yuya Morita
Technical Staff II
Emi Kiyohara
Technical Staff II
Tamotsu Zako
Senior Visiting Scientist
Naoki Kanayama
Visiting Scientist
Naoki Sasaki
Visiting Scientist
Makoto Takemasa
Visiting Scientist
Yoshitsugu Akiyama
Visiting Scientist
Yoshiyuki Kowada
Visiting Scientist
Masumi Furumoto
Part-time Worker
Takahito Fujii
Temporary Staffing

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: mizuo [at] riken.jp

Related links

Publications

Annual research report