Centers & Labs

Chief Scientist Laboratories

Bioengineering Laboratory

Chief Scientist: Mizuo Maeda (D.Eng.)
Mizuo  Maeda(D.Eng.)

The principal purpose of the laboratory is to explore a new frontier of research field which fuses engineering and biological science. On the basis of polymer chemistry, analytical chemistry, surface chemistry, biochemistry and molecular biology, we are studying on new materials comprising biological components, novel methodology for bioanalysis and medical diagnosis, and artificial systems for regulation of biological processes. Those new ideas and materials are being applied to the field of biomaterials science, environmental science, micro/nanoscience, life science and medical engineering. For example, we newly prepared DNA-vinyl polymer conjugates which have been applied for DNA biosensor, affinity electrophoresis, SNPs-responsive diagnostic nanoparticle, gene-responsive hydrogel, artificial gene regulation system, etc. These researches may be classified into a new category, i.e., "DNA engineering".

Main Research Field

Chemistry

Related Research Fields

Complex systems / Engineering

Analytical chemistry / Biomaterials science / Macromolecular chemistry

Keywords

  • nanoparticle
  • DNA
  • sensor
  • bio conjugate
  • bio macromolecule

Selected Publications

  1. Wang, G., Akiyama, Y., Kanayama, N., Takarada, T., and Maeda, M.:
    "Directed Assembly of Gold Nanorods by Terminal-Base Pairing of Surface-Grafted DNA"
    Small, in press.
  2. Hasegawa, K., Negishi, R., Matsumoto, M., Yohda, M., Hosokawa, K., and Maeda, M.:
    "Specificity of microRNA detection on a power-free microfluidic chip with laminar flow-assisted dendritic amplification"
    Anal. Sci., 33, 171-177 (2017).
  3. Ozasa, K., Won, J., Song, S., Tamaki, S., Ishikawa, T., and Maeda, M.:
    "Temporal change of photophobic step-up responses of Euglena gracilis investigated through motion analysis"
    PLOS ONE, 12, e0172813 (2017).
  4. Wang, G., Akiyama, Y., Shiraishi, S., Kanayama, N., Takarada, T., and Maeda, M.:
    "Cross-Linking versus Non-Cross-Linking Aggregation of Gold Nanoparticles Induced by DNA Hybridization: A Comparison of the Rapidity of Solution Color Change"
    Bioconjugate Chem. 28, 270-277 (2017).
  5. Fukazawa,K., Nakao,A., Maeda,M., Ishihara,K.:
    “Photoreactive Initiator for Surface-Initiated ATRP on Versatile Polymeric Substrates“
    ACS Appl. Mater. Interfaces, 8, 24994−24998 (2016)
  6. Kanayama, N., Sekine, T., Ozasa, K., Kishi, S., Nyu, T., Hayashi, T. and Maeda, M.:
    "Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force"
    Langmuir 32, 13296-13304 (2016).
  7. Fujita,M., Hiramine, H., Pan, P., Hikima, T., and Maeda, M.:
    "Effects of Complementary DNA and Salt on the Thermoresponsiveness of Poly(N-isopropylacrylamide)-b-DNA"
    Langmuir, 32, 1148-1154 (2016).
  8. Kondo, E., Wada, K., Hosokawa, K.,, and Maeda, M.:
    "Cryopreservation of adhered mammalian cells on a microfluidic device: toward ready-to-use cell-based experimental platforms"
    Biotechnol. & Bioeng., 113, 237-240 (2016).
  9. Hiraishi, T., Abe H., and Maeda, M.:
    "Substrate stereoselectivity of poly(Asp) hydrolase-1 capable of cleaving β-amide bonds as revealed by investigation of enzymatic hydrolysis of stereoisomeric β-tri(Asp)s"
    AMB Express, 5, 31 (2015).
  10. Ma, C., Pan, P., Shan, G., Bao, Y., Fujita, M., and Maeda, M.:
    "Core-Shell Structure, Biodegradation, and Drug Release Behavior of Poly(lactic acid)/Poly(ethylene glycol) Block Copolymer Micelles Tuned by Macromolecular Stereostructure"
    Langmuir, 31, 1527-1536 (2015).

Lab Members

Principal Investigator

Mizuo Maeda
Chief Scientist

Core Members

Kazunari Ozasa
Senior Research Scientist
Aiko Nakao
Senior Research Scientist
Tomohiro Hiraishi
Senior Research Scientist
Akiko Yamaji
Senior Research Scientist
Kazuo Hosokawa
Senior Research Scientist
Masahiro Fujita
Senior Research Scientist
Tohru Takarada
Senior Research Scientist
Young-Jin Kim
Special Postdoctoral Researcher
Rodtichoti Wannapob
Postdoctoral Researcher
Ken-Ichi Wada
Contract Researcher
Yuji Tsuchido
Contract Researcher
Takafumi Sako
Junior Research Associate
Li Yu
International Program Associate
Surachada Chuaychob
International Program Associate
Tzung-Ying Yang
Student Trainee
Yoshifumi Sakamoto
Student Trainee
Masaya Inoue
Student Trainee
Tamotsu Zako
Senior Visiting Scientist
Naoki Kanayama
Visiting Scientist
Naoki Sasaki
Visiting Scientist
Makoto Takemasa
Visiting Scientist
Yoshitsugu Akiyama
Visiting Scientist
Guoqing Wang
Visiting Scientist
Yoshiyuki Kowada
Visiting Scientist
Fuyuki Ito
Visiting Scientist
Satomi Yanaba
Research Part-time Worker II
Masumi Furumoto
Administrative Part-time Worker II
Kumiko Matsumoto
Administrative Part-time Worker II
Hideo Tomita
Temporary Staffing
Akiko Nakamura
Temporary Staffing

Contact information

Cooperation Center
2-1 Hirosawa, Wako, Saitama
351-0198, Japan
Tel:+81-(0)48-462-9312
Tel:+81-(0)48-462-4658

Email: mizuo [at] riken.jp

Related links

Publications

Annual research report