Centers & Labs

Chief Scientist Laboratories

Elements Chemistry Laboratory

Chief Scientist: Masanobu Uchiyama (D.Phar.)
Masanobu  Uchiyama(D.Phar.)

Research in our laboratory spans the traditional areas of organic, inorganic and physical chemistry as well as interdisciplinary areas of modern chemical research, focusing in particular on the chemistry of elements (elements chemistry). We aim to better understand the reactions, properties, and structures of chemical substances not only by means of experimental approaches based on synthetic organic chemistry and spectroscopy, but also from a theoretical viewpoint based on computational chemistry. Our research interests include development of innovative chemical reactions, and design and synthesis of new functional molecules.

Main Research Field


Related Research Fields

Medicine, dentistry, and pharmacy

Chemical Pharmaceutical Science


  • Organic Chemistry
  • Synthetic Chemistry
  • Elements Chemistry
  • Theoretical Chemistry
  • Pharmaceutical Sciences

Selected Publications

  1. Wang, D.-Y., Kawahata, M., Yang, Z-K., Miyamoto, K., Komagawa, S., Yamaguchi, K., Wang, C.,* and Uchiyama, M.:
    "Stille Coupling via C–N Bond Cleavage"
    Nature. Commun., 7, 12937 (2016).
  2. Tezuka, N., Shimojo, K., Hirano, K.,* Komagawa, S., Yoshida, K., Wang, C., Miyamoto, K., Saito, T., Takita, R., and Uchiyama, M.:
    "Direct Hydroxylation and Amination of Arenes via Deprotonative Cupratio"
    J. Am. Chem. Soc., 138, 9166–9171 (2016).
  3. Sato, H., Teramoto, K., Masumoto, Y., Tezuka, N., Sakai, K., Ueda, S., Totsuka, Y., Shinada, T., Nishiyama, M., Wang, C., Kuzuyama, T., and Uchiyama, M.:
    ""Cation-Stitching Cascade": exquisite control of terpene cyclization in cyclooctatin biosynthesis"
    Sci. Rep. 5, Article number: 18471 (2015).
  4. Otsuka, M., Takita, R., Kanazawa, J., Miyamoto, K., Muranaka, A., and Uchiyama, M.:
    "Conjugation between σ- and π-Aromaticity in 1-C-Arylated Monocarba-closo-dodecaborate Anions"
    J. Am. Chem. Soc. 137, 15082-15085 (2015).
  5. Wang, D.-Y., Wang, C., and Uchiyama, M.:
    "Stannyl-Lithium: A Facile and Efficient Synthesis Facilitating Further Applications"
    J. Am. Chem. Soc. 137, 10488–10491 (2015).
  6. Minami, H., Saito, T., Wang, C., and Uchiyama, M.:
    "Organoaluminum-Mediated Direct Cross-Coupling Reaction"
    Angew. Chem. Int. Ed. 54, 4665-4668 (2015).
  7. Toriumi, N., Muranaka, A., Kayahara, E., Yamago, S., and Uchiyama, M.:
    "In-plane Aromaticity in Cycloparaphenylene Dications: A Magnetic Circular Dichroism and Theoretical Study"
    J. Am. Chem. Soc. 137, 82-85 (2015).
  8. Mizukoshi, Y., Mikami, K., and Uchiyama, M.:
    "Aryne Polymerization Enabling Straightforward Synthesis of Elusive Poly(ortho-arylene)s"
    J. Am. Chem. Soc. 137, 74-77 (2015).
  9. Nagashima, Y., Hirano, K., Takita, R., and Uchiyama, M.:
    "Trans-Diborylation of Alkynes: Pseudo-Intramolecular Strategy Utilizing Propargylic Alcohol Unit"
    J. Am. Chem. Soc. 136, 8532-8535 (2014).
  10. Toriumi, N., Muranaka, A., Hirano, K., Yoshida, K., Hashizume, D., and Uchiyama, M.:
    "18π Tautomeric Benziphthalocyanine: A Functional Near-IR Dye with Tunable Aromaticity"
    Angew. Chem. Int. Ed. 53, 7814-7818 (2014).

Lab Members

Principal Investigator

Masanobu Uchiyama
Chief Scientist

Core Members

Tetsuya Aoyama
Senior Research Scientist
Atsuya Muranaka
Senior Research Scientist
Yui Masumoto
Junior Research Associate
Zekun Yang
Junior Research Associate
Gaku Akimoto
Student Trainee
Yuzuki Miura
Student Trainee
Yusuke Tanaka
Student Trainee

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: uchi_yama [at]

Annual research report