Centers & Labs

Chief Scientist Laboratories

Nano Medical Engineering Laboratory

Chief Scientist: Yoshihiro Ito (D.Eng.)
Yoshihiro  Ito(D.Eng.)

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Main Research Field

Complex systems

Related Research Fields

Engineering

Bio-related chemistry / Molecular biology / Polymer chemistry

Keywords

  • Artificial Organ Material
  • Biosensor
  • Regenerative Medicine Material
  • Biochip
  • Functional Polymeric Materials

Selected Publications

  1. Nair, B. G., Zhou, Y., Hagiwara, K., Ueki, M., Isoshima, T., Abe, H. and Ito, Y.:
    "Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1”trimer siRNA"
    J. Mater. Chem. B, 5, 4044-4051 (2017)
  2. Maruyama, H., Oikawa, R., Hayakawa, M., Takamori, S., Kimura, Y., Abe, N., Tsuji, G., Akira Matsuda, A., Shuto, S., Ito, Y. and Abe, H.:
    "Chemical ligation of oligonucleotides using an electrophilic phosphorothioester"
    Nucleic Acid Res., 45, 7042-7048 (2017)
  3. Mao, H., Kim, S. M., Ueki, M. and Ito, T.:
    "Serum-free culturing of human mesenchymal stem cells with immobilized growth factors"
    J. Mater. Chem. B, 5, 928-934 (2017)
  4. Wang, W., Zhu, L., Hirano, Y., Karamiavargani, M., Tada, S., Zhang, G., Uzawa, T., Zhang, D., Hirose, T., Taiji, M. and Ito,Y.:
    "Fluorogenic enhancement of in vitro selected binding peptide ligand by replacement of fluorescent group"
    Anal. Chem., 88, 7991-7997 (2016)
  5. Nair B. G., Hagiwara, H., Ueda, M., Yu, H.-h., Tseng, H.-R. and Ito,Y.:
    "High density of aligned nanowire treated with polydopamine for efficient gene silencing by siRNA according to cell membrane perturbation"
    ACS Appl. Mater. Inter., 8, 18693-18700 (2016)
  6. Zhang, C., Miyatake, H., Wang, Y., Inaba, T., Wang, Y., Zhang, P. and Ito, Y.:
    "A bioorthogonal approach for the preparation of a titanium-binding insulin-like growth factor-1 derivative using tyrosinase"
    Angew. Chem. Int. Edn., 55, 11447-11451 (2016)
  7. Zhao, H., Jiang, G., Weng, J., Ma, Q., Zhang, H., Ito Y. and Liu, M.:
    "Signal-accumulating DNAzyme-crosslinked hydrogel for colorimetric sensing of hydrogen peroxide"
    J. Mater. Chem. B, 4, 4648-4651 (2016)
  8. Wang, W., Hirano, Y., Uzawa, T., Taiji, M. and Ito, Y.:
    "Assisted enhancement of inhibitory effects of small molecular inhibitors for kinases"
    Bull. Chem. Soc. Jpn., 89, 444-446 (2016)
  9. Wang, Z., Xu, Y., Wang, Y., Ito, Y., Zhang, P. and Chen, X.:
    "Enhanced in vitro mineralization and in vivo osteogenesis of composite scaffolds through controlled surface grafting of L-lactic acid oligomer on nano-hydroxyapatite"
    Biomacromolecules, 17, 818-829 (2016)
  10. Gisbergen, M. v., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., Tew, K., Townsend, D., Haenen, G., Drittij-Reijnders, M.-J., Saneyoshi, H., Araki, M., Shishido, Y., Ito, Y., Arner, E., Abe, H., Morgenstern, R. and Johansson, K.:
    "A chemical reactivity window determines prodrug efficiency towards glutathione transferase overexpressing cancer cells"
    Mol. Pharm., 13, 2010-2025 (2016)

Lab Members

Principal Investigator

Yoshihiro Ito
Chief Scientist

Core Members

Yoko Aida
Senior Research Scientist
Nobuhiro Morishima
Senior Research Scientist
Takashi Isoshima
Senior Research Scientist
Hideyuki Miyatake
Senior Research Scientist
Masashi Ueki
Senior Research Scientist
Takanori Uzawa
Senior Research Scientist
Masuki Kawamoto
Senior Research Scientist
Motoki Ueda
Research Scientist
Baiju Govindan Nair
Special Postdoctoral Researcher
Jun Akimoto
Special Postdoctoral Researcher
Liping Zhu
Visiting Researcher
Shin-Hye PARK
Visiting Researcher
Hongli Mao
Visiting Researcher
Nandakumar Avanashiappan
Visiting Researcher
Marziyeh Karimiavargani
Junior Research Associate
Seong Min Kim
Junior Research Associate
Hadjer Salmi
International Program Associate
Chen Zhang
International Program Associate
Roopa Dharmatti
International Program Associate
Morteza Mahmoudisaber
Student Trainee
Kon Son
Student Trainee
Naoko Morita
Technical Staff I
Kuniharu Ijiro
Senior Visiting Scientist
Masayuki Yamamura
Senior Visiting Scientist
Hiroshi Abe
Senior Visiting Scientist
Yoshihito Osada
Senior Visiting Scientist
Toshiro Aigaki
Senior Visiting Scientist
Yasuhiro Yoshida
Senior Visiting Scientist
Eiry Kobatake
Senior Visiting Scientist
Daisuke Kiga
Senior Visiting Scientist
Mingzhe Liu
Visiting Scientist
Tae-il Son
Visiting Scientist
Mariko Nakamura
Visiting Scientist
Peibiao Zhang
Visiting Scientist
Binata Joddar
Visiting Scientist
Akon Higuchi
Visiting Scientist
Kyoko Yamanaka
Part-time Worker

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: y-ito [at] riken.jp

Related links

Recent research results

Annual research report