Centers & Labs

Chief Scientist Laboratories

Nano Medical Engineering Laboratory

Chief Scientist: Yoshihiro Ito (D.Eng.)
Yoshihiro  Ito(D.Eng.)

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Main Research Field


Related Research Fields

Chemistry / Materials Sciences / Biology & Biochemistry / Multidisciplinary

Research Subjects

  • Biomaterials for regenerative medicine
  • Nanomedicine using RNAi
  • Development of microarray biochips
  • Development of molecular probes for cellular imaging
  • Development of high perfromance organic catalyst by combinatorial engineering

Selected Publications

  1. Zhou, Y., Mao, H., Joddar, B., Umeki, N., Yasushi Sako, Y., Wada, K., Nishioka, C., Takahashi, E., Wang, Y. and Ito Y.:
    "The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness"
    Sci. Rep., 5, 11386 (2015)
  2. Abe, N., Matsumoto, K., Nishihara, M., Nakano, Y., Shibata, A., Maruyama, H., Shuto, S., Matsuda, A., Yoshida, M., Ito, Y. and Abe, H.:
    "Circle translation of circular RNA in living human cells"
    Sci. Rep., 5, 16435 (2015)
  3. Nakayama, N., Hagiwara, K., Ito, Y., Ijiro, K., Osada, Y., and Sano, K.:
    "Superior cell penetration by a rigid and anisotropic synthetic protein"
    Langmuir, 31, 2826-2832 (2015)
  4. Seo, S., Onizuka, K., Nishioka, C., Takahashi, E., Tsuneda, S., Abe, H. and Ito, Y.:
    "Phosphorylated 5-ethynyl-2’-deoxyuridine for advanced DNA labeling"
    Org. Biomol. Chem., 13, 4589-4595 (2015)
  5. Joddar, B., Nishioka, C., Takahashi, E., and Ito, Y.:
    "Chemically fixed autologous feeder cell-derived niche for human induced pluripotent stem cell culture"
    J. Mater. Chem. B, 3, 2301-2307, (2015)
  6. Zang, Q., Tada, S., Uzawa, T., Kiga, D., Yamamura, M. and Ito, Y.:
    "Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide"
    Chem. Commun., 51, 14385-14388 (2015)
  7. Wada, K., Hosokawa, K., Ito, Y. and Maeda, M.:
    "Effects of ROCK inhibitor Y-27632 on cell fusion through a microslit"
    Bioeng. Biotechnol., 112, 2334-2342 (2015)
  8. Zhou, X., Park, S.-H., Mao, H., Isoshima, T., Wang, Y., and Ito, Y.:
    "Nanolayer formation on titanium by phosphonated gelatin for cell adhesion and growth enhancement"
    Int. J. Nanomed., 10, 5597-5607 (2015)
  9. Zhu, L., Wang, W., Zhao, H., Xu, M., Tada, S., Uzawa, T., Liu, M. and Ito, Y.:
    "Dual functional peptide carrying in vitro selected catalytic and binding activities"
    Org. Biomol. Chem., 13, 9808-9812 (2015)
  10. Nakayama, N., Hagiwara, K., Ito, Y., Ijiro, K., Osada, Y., and Sano, K.:
    "Noncationic rigid and anisotropic coiled-coil proteins exhibit cell-penetration activity"
    Langmuir, 31, 8218-8223 (2015)

Lab Members

Principal Investigator

Yoshihiro Ito
Chief Scientist

Core Members

Yoko Aida
Senior Research Scientist
Nobuhiro Morishima
Senior Research Scientist
Takashi Isoshima
Senior Research Scientist
Hideyuki Miyatake
Senior Research Scientist
Masashi Ueki
Senior Research Scientist
Takanori Uzawa
Senior Research Scientist
Masuki Kawamoto
Senior Research Scientist
Motoki Ueda
Research Scientist
Baiju Govindan Nair
Special Postdoctoral Researcher
Jun Akimoto
Special Postdoctoral Researcher
Liping Zhu
Visiting Researcher
Shin-Hye PARK
Visiting Researcher
Hongli Mao
Visiting Researcher
Nandakumar Avanashiappan
Visiting Researcher
Marziyeh Karimiavargani
Junior Research Associate
Seong Min Kim
Junior Research Associate
Hadjer Salmi
International Program Associate
Chen Zhang
International Program Associate
Roopa Dharmatti
International Program Associate
Morteza Mahmoudisaber
Student Trainee
Kon Son
Student Trainee
Naoko Morita
Technical Staff I
Kuniharu Ijiro
Senior Visiting Scientist
Masayuki Yamamura
Senior Visiting Scientist
Hiroshi Abe
Senior Visiting Scientist
Yoshihito Osada
Senior Visiting Scientist
Toshiro Aigaki
Senior Visiting Scientist
Yasuhiro Yoshida
Senior Visiting Scientist
Eiry Kobatake
Senior Visiting Scientist
Daisuke Kiga
Senior Visiting Scientist
Mingzhe Liu
Visiting Scientist
Tae-il Son
Visiting Scientist
Mariko Nakamura
Visiting Scientist
Peibiao Zhang
Visiting Scientist
Binata Joddar
Visiting Scientist
Akon Higuchi
Visiting Scientist
Kyoko Yamanaka
Part-time Worker

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: y-ito [at]

Related links

Recent research results

Annual research report