Centers & Labs

Chief Scientist Laboratories

Plant Epigenome Regulation Laboratory

Chief Scientist: Motoaki Seki (Ph.D.)
Motoaki  Seki(Ph.D.)

Our laboratory aims to elucidate the molecular mechanisms of epigenome regulation networks in plant life cycle. To understand this topic involving histone modification and non-coding RNAs, we perform cutting-edge multidisciplinary approaches using model plants, including molecular biology, chemical biology and integrated omics analysis.

Main Research Field

Chemistry / Biological Sciences / Agricultural sciences

Related Research Fields

Biology

Keywords

  • Environmental stress adaptation
  • Epigenome regulation
  • RNA regulation
  • Chemical regulation
  • Molecular breeding of useful cassava plants

Selected Publications

  1. Nakaminami, K., Okamoto, M., Higuchi-Takeuchi, M., Yoshizumi, T., Yamaguchi, Y., Fukao, Y., Shimizu, M., Ohashi, C., Tanaka, M., Matsui, M., Shinozaki, K., Seki, M.* and Hanada, K.*.:
    ”AtPep3 is a hormone-like peptide that plays a role in salinity stress tolerance of plants.”
    Proc. Natl. Acad. Sci. USA 115, 5810-5815 (2018).
  2. Ueda, M., Matsui, A., Tanaka, M., Nakamura, T., Abe, T., Sako, K., Sasaki, T., Kim, J.M., Ito, A., Nishino, N., Shimada, H., Yoshida, M. and Seki, M.:
    “The distinct role of RPD3-like histone deacetylases between class I and II in salinity stress response” Plant Physiol. 175:1760-1773 (2017).
  3. Matsui, A., Iida, K., Tanaka, M., Yamaguchi, K., Mizunashi, K., Kim, J.M., Takahashi, S., Kobayashi, N., Shigenobu, S., Shinozaki, K. and Seki, M.:
    “Novel stress-inducible antisense RNAs of protein-coding loci are synthesized by Arabidopsis RDRs”
    Plant Physiol. 175: 457-472 (2017).
  4. Nguyen, H.M., Sako, K., Matsui, A., Suzuki, Y., Mostofa, M.G., Ha, C.V., Tanaka, M., Tran, L.S.P., Habu, Y. and Seki, M.:
    “Ethanol enhances high-salinity stress tolerance by detoxifying reactive oxygen species in Arabidopsis thaliana and rice”
    Front. Plant Sci. 8: 1001 (2017).
  5. Kim, J.M., To, K.T., Matsui, A., Tanoi, K., Kobayashi, N.I., Matsuda, F., Habu, Y., Ogawa, D., Sakamoto, T., Matsunaga, S., Bashir, K., Rasheed, S., Ando, M., Takeda, H., Kawaura, K., Kusano, M., Fukushima, A., Endo, A.T., Kuromori, T., Ishida, J., Morosawa, T., Tanaka, M., Torii, C., Takebayashi, Y., Sakakibara, H., Ogihara, Y., Saito, K., Shinozaki, K., Devoto, A. and Seki, M.:
    “Acetate-mediated novel survival strategy against drought in plants”
    Nature Plants 3: 17097 (2017).
  6. Sako, K., Kim, J.M., Matsui, A., Nakamura, K., Tanaka, M., Kobayashi, M., Saito, K., Nishino, N., Kusano, M., Taji, T., Yoshida, M. and Seki, M.:
    “Ky-2, a histone deacetylase inhibitor, enhances high-salinity stress tolerance in Arabidopsis thaliana”
    Plant Cell Physiol. 57:776-783 (2016)
  7. To, T.K., Kim, J.M., Matsui, A., Kurihara, Y., Morosawa, T., Ishida, J., Tanaka, M., Endo, T., Kakutani, T., Toyoda, T., Kimura, H., Yokoyama, S., Shinozaki, K. and Seki, M.:
    “Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET1”
    PLoS Genet. 7:e1002055 (2011).
  8. Kurihara, Y., Matsui, A., Hanada, K., Kawashima, M., Ishida, J., Morosawa, T., Tanaka, M., Kaminuma, E., Mochizuki, Y., Matsushima, A., Toyoda, T., Shinozaki, K. and Seki, M.:
    “Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis”
    Proc. Natl. Acad. Sci. USA 106:2453-2458 (2009).
  9. Matsui, A., Ishida, J., Morosawa, T., Mochizuki, Y., Kaminuma, E., Endo, T.A., Okamoto, M., Nambara, E., Nakajima, M., Kawashima, M., Satou, M., Kim, J.M., Kobayashi, N., Toyoda, T., Shinozaki, K. and Seki, M.: “Arabidopsis Transcriptome Analysis under Drought, Cold, High-Salinity and ABA Treatment Conditions using a Tiling Array”
    Plant Cell Physiol. 49: 1135-1149 (2008).
  10. Seki, M., Narusaka, M., Kamiya, A., Ishida, J., Satou, M., Sakurai, T., Nakajima, M., Enju, A., Akiyama, K., Oono, Y., Muramatsu, M., Hayashizaki, Y., Kawai, J., Carninci, P., Itoh, M., Ishii, Y., Arakawa, T., Shibata, K., Shinagawa, A. and Shinozaki, K.:
    “Functional annotation of a full-length Arabidopsis cDNA collection”
    Science 296: 141-145 (2002).