Centers & Labs

Chief Scientist Laboratories

Synthetic Organic Chemistry Laboratory

Chief Scientist: Mikiko Sodeoka (D.Phar.)
Mikiko  Sodeoka(D.Phar.)

Our laboratory focuses on the following research areas based on synthetic organic chemistry: 1) development of new reactions and methodologies for the efficient synthesis of bioactive molecules, 2) design and synthesis of molecules having unique biological activity, 3) biological researches using these unique molecules as biological probes. Our research interests encompass from transition metal-catalyzed enantioselective reactions to the design and synthesis of intracellular signal transduction modulators and their application to cell biology research. Design and synthesis of selective inhibitors of protein kinases and phosphatases, which are involved in the signal transduction of cell proliferation, aiming for the clarification of the functions of their target enzymes are of particular interest. Clarification of the unknown molecular mechanism of cell death (necrosis) by using our original cell death control molecules is also currently underway. We are also working on the synthesis of ganglioside analogues and several other natural products having interesting biological activities.

Main Research Field

Chemistry

Related Research Fields

Biology & Biochemistry / Molecular Biology & Genetics

Research Subjects

  • Development of novel catalytic enantioselective reactions
  • Development of selective inhibitors of protein kinases and phosphatases
  • Development of cell death inhibitors and clarification of their molecular mechanism of action
  • Development of molecular probes for clarification of gangliosides
  • Development of new chemical method for the chemical biology research

Selected Publications

  1. Kawamura, S., Egami. H., and Sodeoka, M.:
    "Aminotrifluoromethylation of Olefins via Cyclic Amine Formation: Its Mechanistic Study and Application to Synthesis of Trifluoromethylated Pyrrolidines"
    J. Am. Chem. Soc. 137, 4865-4873 (2015).
  2. Hirai, G., and Sodeoka, M.:
    "Focused Library with Core Structure Extracted from Natural Products and Modified: Application to Phosphatase Inhibitors and Several Biochemical Findings"
    Acc. Chem. Res. 48, 1464-1473 (2015).
  3. Ando, J., Kinoshita, M., Cui, J., Yamakoshi, H., Dodo, K., Fujita, K., Murata, M., and Sodeoka, M.:
    "Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy"
    Proc. Nat. Acad. Sci. 112, 4546-4551 (2015).
  4. Egami, H., and Sodeoka, M.:
    "Recent Progress on Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups"
    Angew. Chem. Int. Ed. 53, 2894-8308 (2014).
  5. Yamaguchi, T., Asanuma, M., Nakanishi, S., Saito, Y., Okazaki, M., Dodo, K., and Sodeoka, M.:
    "Turn-ON Fluorescent Affinity Labeling Using a Small Bifunctional O-Nitrobenzoxadiazole Unit"
    Chem. Sci. 5, 1021-1029 (2014).
  6. Egami, H., Ide, T., Fujita, M., Tojo, T., Hamashima, Y., and Mikiko Sodeoka.:
    "Alkene Trifluoromethylation Coupled with C-C Bond Formation: Construction of Trifluoromethylated Carbocycles and Heterocycles"
    Angew. Chem. Int. Ed. 52, 4000-4003 (2013).
  7. Egami, H., Kawamura, S., Miyazaki, A., and Sodeoka, M.:
    "Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines"
    Angew. Chem. Int. Ed. 52, 7841-7844 (2013).
  8. Ozawa, M., Morita, M., Hirai, G., Tamura, S., Kawai, M., Tsuchiya, A., Oonuma, K., Maruoka, K., and Sodeoka, M.:
    "Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Action"
    ACS Med. Chem. Lett. 4, 730-735 (2013).
  9. Tsuchiya, A., Asanuma, M., Hirai, G., Oonuma, K., Muddassar, M., Nishizawa, E., Koyama, Y., Otani, Y., Zhang, K. Y. J., and Sodeoka, M.:
    "CDC25A-inhibitory RE Derivatives Bind to Pocket Adjacent to the Catalytic Site"
    Mol. BioSyst. 9, 1026-1034 (2013).
  10. Yamakoshi, H., Dodo, K., Palonpon, A. F., Ando, J., Fujita, K., Kawata, S., and Sodeoka, M.:
    "Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells"
    J. Am. Chem. Soc. 134, 20681-20689 (2012).

Lab Members

Principal Investigator

Mikiko Sodeoka
Chief Scientist

Core Members

Go Hirai
Senior Research Scientist
Kosuke Dodo
Senior Research Scientist
Yoshihiro Sohtome
Research Scientist
Kenji Ohgane
Special Postdoctoral Researcher
Miwako Asanuma
Postdoctoral Researcher
Kenji Hayamizu
Postdoctoral Researcher
Masaki Morita
Postdoctoral Researcher
Shusuke Egoshi
Postdoctoral Researcher
Eisuke Ota
Postdoctoral Researcher
Qianqian Wang
Postdoctoral Researcher
Masumi Sugawara
Postdoctoral Researcher
Elena Valverde Murillo
Visiting Researcher
Ryo Fukazawa
Junior Research Associate
Yu Mikame
Junior Research Associate
Cassandra Henderson
Student Trainee
Sho Fukushima
Student Trainee
Fumihiko Natori
Student Trainee
Naoki Terayama
Technical Staff I
Daisuke Sekine
Technical Staff I
Mai Akakabe
Technical Staff I
Izumi Saito
Assistant
Yasuo Hibino
Part-time Worker
Xiuling Wang
Part-time Worker
Tomomi Fukuda
Temporary Staffing

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: sodeoka [at] riken.jp

Related links

Recent research results

Annual research report

Further information