Centers & Labs

Chief Scientist Laboratories

Theoretical Biology Laboratory

Chief Scientist: Atsushi Mochizuki (D.Sci.)
Atsushi  Mochizuki(D.Sci.)

The progress of modern biology revealed that biological phenomena are governed by complex network systems including many molecules, cells or organs. For the aim of understanding the functions of complex systems, we adopt mathematical and computational methods. By theoretical approaches we decipher huge amounts of experimental information, and to give integrative understanding for the biological systems. Our final goal is to open a new bioscience which will progress by the repeats of the theoretical predictions and the experimental verifications. We are promoting multiple projects of collaborations with experimental biologists. The followings are some examples of our projects for these four years.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Physics / Biology & Biochemistry / Mathematics / Multidisciplinary

Research Subjects

  • Studying biological phenomena by mathematical or theoretical methods
  • Dynamics of complex network systems
  • Physical or mathematical study for pattern formations

Selected Publications

  1. Mochizuki A., and Fiedler B.:
    "Sensitivity of chemical reaction networks: a structural approach. 1. Examples and the carbon metabolic network."
    J. Theor. Biol. 367, 189-202 (2015).
  2. Tachikawa M., and Mochizuki A.:
    "Nonlinearity in cytoplasm viscosity can generate an essential symmetry breaking in cellular behaviors."
    J. Theor. Biol. 364, 260-265 (2015).
  3. Hayakawa Y., Tachikawa M., and Mochizuki A.:
    "Mathematical study for the mechanism of vascular and spot patterns by auxin and PIN dynamics in plant development."
    J. Theor. Biol. 365, 12-22 (2015).
  4. Ichikawa T., Nakazato K., Keller P.J., Kajiura-Kobayashi H., Stelzer E.H.K, Mochizuki A. and Nonaka S.:
    "Live imaging and quantitative analysis of whole mouse embryos during gastrulation using light-sheet microscopy and three-dimensional tracking tools."
    Nature Protocols, 9, 575-585 (2014).
  5. Nonomura K., Yamaguchi Y., Hamachi M., Koike M., Uchiyama Y., Nakazato K., Mochizuki A., Sakaue-Sawano A., Miyawaki A., Yoshida H., Kuida K., and Miura M.:
    "Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells."
    Dev. Cell. 27, 621-634(2013).
  6. Fiedler B., Mochizuki A., Kurosawa G. and Saito D.:
    "Dynamics and control at feedback vertex sets. I: Informative and determining nodes in regulatory networks."
    J. Dyn. Differ. Eqns. 25, 563-604 (2013).
  7. Nakamura T., Saito D., Kawasumi A., Shinohara K., Asai Y., Takaoka K., Dong F., Takamatsu A., Belo J. A., Mochizuki A. and Hamada H.:
    "Fluid Flow and Interlinked Feedback Loops Establish Left-Right Asymmetric Decay of Cerl2 mRNA in the Mouse Embryo."
    Nat. Commun. 3, 1322 (2012).
  8. Takasu N. N., Kurosawa G., Tokuda T. I., Mochizuki A., Todo T., Nakamura W.:
    "Circadian regulation of food-anticipatory activity in molecular clock-deficient mice."
    PLoS ONE 7, e48892 (2012).
  9. Fujishima K., Horie R., Mochizuki A. and Kengaku M.:
    "Principle branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites."
    Development 139, 3442-3455 (2012).
  10. Mochizuki A. and Saito D.:
    "Analyzing steady states of dynamics of bio-molecules from the structure of regulatory networks."
    J. Theor. Biol. 266, 323-335 (2010).

Lab Members

Principal Investigator

Atsushi Mochizuki
Chief Scientist

Core Members

Masashi Tachikawa
Research Scientist
Gen Kurosawa
Research Scientist
Kenichi Nakazato
Postdoctoral Researcher
Takashi Okada
Postdoctoral Researcher
Shingo Gibo
Postdoctoral Researcher
Fumito Mori
Contract Researcher
Yoshinori Hayakawa
Technical Staff II