Centers & Labs

RIKEN Center for Life Science Technologies

Bio-Function Imaging Team

Team Leader: Hirotaka Onoe (Ph.D.)
Hirotaka  Onoe(Ph.D.)

For integrative understanding of the biological phenomena in life, we develop the method of dynamic imaging for complex biological and cellular functions under living state in the normal and disease-model animals of various species, including primates. In addition, we develop the novel molecular imaging probes, which are required for drug development work together cooperatively with the Labelling Chemistry Team.

Research Subjects

  • Development of new-generation original PET radiotracers
  • Development of molecular imaging techniques for monitoring biological events

Selected Publications

  1. Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H.:
    “Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys.”
    J Neurosci., 35(1), 84-95 (2015).
  2. Susaki EA, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe TM, Yokoyama C, Onoe H, Eguchi M, Yamaguchi S, Abe T, Kiyonari H, Shimizu Y, Miyawaki A, Yokota H, Ueda HR.:
    “Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis.”
    Cell, 157(3), 726-739 (2014).
  3. Yamanaka H, Yokoyama C, Mizuma H, Kurai S, Finnema S,J, Halldin C, Doi H, Onoe H.:
    “A possible mechanism of the nucleus accumbens and ventralpallidum 5-HT1B receptors underlying the antidepressantaction of ketamine: a PET study with macaques”
    Transl Psychiatry, 4, e342 (2014).
  4. Yokoyama, C; Kawasaki, A; Hayashi, T; Onoe, H :
    “Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets”
    Cereb. Cortex, 23(9), 2136-2145 (2013).
  5. Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG:
    “Imaging Epigenetic Regulation by Histone Deacetylases in the Brain using PET/MRI with 18F-FAHA”
    Neuroimage, 64, 630-639 (2013).
  6. Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H.:
    “Evaluation of dopamine D2/D3 and serotonin 5-HT2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography.”
    Psychopharmacology (Berl)., 225(2), 329-339 (2013).
  7. Kawasaki T, Marumo T, Shirakami K, Mori T, Doi H, Suzuki M, Watanabe Y, Chaki S, Nakazato A, Ago Y, Hashimoto H, Matsuda T, Baba A, Onoe H.:
    “Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with (11)C-labeled 20-HETE synthase-specific inhibitor.”
    J Cereb Blood Flow Metab., 32(9), 1737-1746 (2012).
  8. Shukuri M, Takashima-Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, Doi H, Suzuki M, Watanabe Y, Onoe H.:
    “In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester.”
    J Nucl Med., 52(7), 1094-1101 (2011).
  9. Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.:
    “Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.”
    Neurobiol Dis., 42(3), 404-414 (2011).
  10. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H.:
    “Establishment of in vivo brain imaging method in conscious mice.”
    J Nucl Med., 51(7), 1068-1075 (2010).

Lab Members

Principal Investigator

Hirotaka Onoe
Team Leader

Core Members

Tsuyoshi Tahara
Research Scientist
Hiroshi Mizuma
Research Scientist
Kyoko Kakumoto
Research Scientist
Hajime Yamanaka
Postdoctoral Researcher
Shino Owada
Technical Staff I
Michiko Inoue
Technical Staff I
Yoshino Matsumoto
Technical Staff 1
Tadashi Isa
Senior Visiting Scientist
Takashi Tamura
Visiting Scientist
Miho Shukuri
Visiting Scientist
Hiroyuki Takamatsu
Visiting Scientist
Kiyoshi Matsumura
Visiting Scientist
Michio Senda
Visiting Scientist
Masanori Hirashima
Visiting Scientist
Ryuichi Nishii
Visiting Scientist
Shinya Kagawa
Visiting Scientist
Kazuo Hikosaka
Visiting Scientist
Yukio Nishimura
Visiting Scientist
Rikako Kato
Visiting Scientist
Masaharu Kinoshita
Visiting Scientist
Erika Sasaki
Visiting Scientist
Junko Okahara
Visiting Scientist
Tsukasa Takahashi
Visiting Scientist
Yuko Yamada
Visiting Technician
Masamichi Morita
Tomoki Nishioka
Student Trainee
Elise Yuri Lepicard
Student Trainee
Yasunori Otowa
Student Trainee
Michiaki Suzuki
Student Trainee