Centers & Labs

RIKEN Center for Life Science Technologies

Cellular Function Imaging Team

Team Leader: Yosky Kataoka (M.D., Ph.D.)
Yosky  Kataoka(M.D., Ph.D.)

We are investigating physiological or pathological roles of cells functioning in living tissues by using in vivo imaging methods including PET, MRI, and optical imaging. In particular, we aim to establish new strategies for treating neurological disorders or malignancy by imaging stem/progenitor cells in the central nervous system or cancer/cancer stem cells. Further, we study metabolic dynamics in pathophysiological states including fatigue, and develop new techniques for controlling the living systems.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Biological Sciences / Biology

Research Subjects

  • Imaging and functional analysis of stem/progenitor cells in vivo
  • Analysis and control of metabolic dynamics in pathophysiological states including fatigue
  • Development of novel multimodal imaging techniques and photo-dynamic techniques for manipulating cellular function in vivo

Selected Publications

  1. Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.:
    “Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.”
    PLOS ONE, 10(3): e0120106 (2015).
  2. Cui, Y., Toyoda, H., Sako, T., Onoe, K., Hayashinaka, E., Wada, Y.:
    “A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.”
    NeuroImage, 108, 17-22 (2015).
  3. Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.:
    “Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.”
    J. Nucl. Med., 55(6), 945-950 (2014).
  4. Yamato M, Tamura Y, Eguchi A, Kume S, Miyashige Y, Nakano M, Watanabe Y, Kataoka Y.:
    “Brain Interleukin-1 beta and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats.”
    PLOS ONE, 9(3), e90950 (2014).
  5. Kobayashi M, Cui YL, Sako T, Sasabe T, Mizoguchi N, Yamamoto K, Wada Y, Kataoka Y, Koshikawa N.:
    “Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography.”
    J. Neurosci. Res., 91(10), 1363-1370 (2013).
  6. Yamato M, Kaneda A, Kataoka Y.
    “Low-level laser therapy improves crescentic glomerulonephritis in rats.”
    Lasers Med. Sci., 28(4), 1189-1196 (2013).
  7. Cui YL, Li QH, Yamada H, Watanabe Y, Kataoka Y.:
    “Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: A possible pathophysiology of migraine.”
    J. Neurosci. Res., 91(6), 737-744 (2013).
  8. Toba S, Tamura Y, Kumamoto K, Yamada M, Takao K, Hattori S, Miyakawa T, Kataoka Y, Azuma M, Hayasaka K, Amamoto M, Tominaga K, Wynshaw-Boris A, Wanibuchi H, Oka Y, Sato M, Kato M, Hirotsune S.:
    “Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly.”
    Sci Rep., 3, 1224 (2013).
  9. Kataoka Y, Yamato M, Miyashige Y, Tamura Y, Cui Y.:
    “Neuroinflammation in animal models of fatigue.”
    Adv Neuroimmune Biol., 4, 237-244 (2013).
  10. Tamura Y, Eguchi A, Jin G, Sami MM, Kataoka Y.:
    “Cortical spreading depression shifts cell fate determination of progenitor cells in the adult cortex.”
    J Cereb Blood Flow Metab., 32(10), 1879-1887 (2012).

Lab Members

Principal Investigator

Yosky Kataoka
Team Leader

Core Members

Yasuhisa Tamura
Senior Scientist
Masanori Yamato
Research Scientist
Satoshi Kume
Postdoctoral Researcher
Masayuki Nakano
Junior Research Associate
Kumi Takata
Technical Staff I
Asami Eguchi
Technical Staff 2

Contact information

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Email: kataokay [at]

Related links

Recent research results