Centers & Labs

RIKEN Center for Life Science Technologies

Functional Architecture Imaging Team

Team Leader: Takuya Hayashi (M.D., Ph.D.)
Takuya  Hayashi(M.D., Ph.D.)

Using advanced dynamic imaging techniques, we will clarify the interconnections among organs or cells, which are involved in maintaining homeostasis in the body. We specially focus on the unique feature of nervous system—a network architecture and its activity that contribute to adaptive ability related to neural plasticity, regeneration and sociality. We also try to understand mechanism underlining central nervous system function, such in neurodegenerative disease and disorders in self-control.

Main Research Field

Neuroscience & Behavior

Related Research Fields

Engineering / Clinical Medicine / Psychology & Psychiatry

Research Subjects

  • Reorganization of brain network in plasticity
  • Reorganization of brain network in regeneration
  • Transformation and control of brain network in brain disease
  • Sociality, brain network and neurotransmitter

Selected Publications

  1. Takenobu Y, Hayashi T, Moriwaki H, Nagatsuka K, Naritomi H, Fukuyama H.:
    “Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke”
    Neuroimage Clin, 4, 201-208 (2014).
  2. Hayashi T, Onoe H.:
    “Neuroimaging for optimization of stem cell therapy in Parkinson's disease”
    Expert Opin Biol Ther, 13(12), 1631-1638 (2013).
  3. Yokoyama, C; Kawasaki, A; Hayashi, T; Onoe, H.:
    “Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets”
    Cereb Cortex, 23(9), 2136-2145 (2013).
  4. Hayashi T, Ko JH, Strafella AP, Dagher A.:
    “Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving”
    Proc Natl Acad Sci U S A, 110(11), 4422-4427 (2013).
  5. Hayashi T, Shimazawa M, Watabe H, Ose T, Inokuchi Y, Ito Y, Yamanaka H, Urayama S, Watanabe Y, Hara H, Onoe H.:
    “Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma.”
    Mol Neurodegener, 18(8), 4 (2013).
  6. Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.:
    “Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.”
    J Clin Invest, 123(1), 272-284 (2013).
  7. Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H.:
    “Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys.”
    Synapse.64(8):594-601 (2010)
  8. Wakao S, Hayashi T, Kitada M, Kohama M, Matsue D, Teramoto N, Ose T, Itokazu Y, Koshino K, Watabe H, Iida H, Takamoto T, Tabata Y, Dezawa M.:
    “Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration.”
    Exp Neurol, 223(2), 537-547 (2010).
  9. Ikoma Y, Watabe H, Hayashi T, Miyake Y, Teramoto N, Minato K, Iida H.:
    “Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride.”
    J Cereb Blood Flow Metab, 30(3), 663-673 (2010).
  10. Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N.:
    “Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.”
    J Clin Invest, 115(1), 102-109 (2005).

Lab Members

Principal Investigator

Takuya Hayashi
Team Leader

Core Members

Chihiro Yokoyama
Senior Scientist
Masahiro Ohno
Senior Technical Scientist
Sayuki Takara
Research Scientist
Akihiro Kawasaki
Technical Scientist
Chiho Takeda
Technical Scientist
Joonas Autio
Postdoctoral Researcher
Atsushi Yoshida
Postdoctoral Researcher
Yuki Hori
Postdoctoral Researcher
Takayuki Ose
Research Associate
Ryoichi Yokoyama
Part-time Worker
Masataka Yamaguchi
Temporary Staffing

Contact information

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Email: takuya.hayashi [at] riken.jp

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