Centers & Labs

RIKEN Center for Life Science Technologies

Micro-Signaling Regulation Technology Unit

Unit Leader: Soichi Kojima (Ph.D.)
Soichi  Kojima(Ph.D.)

We make basic and applied studies on drug discovery against HBV through development of a unique detection technique(s) and high throughput screenings on novel micro-signaling (therapeutic) targets, discovered using clinical samples from patients with virus infection, liver fibrosis/cirrhosis, liver degeneration, hepatic cancer, and cancer angiogenesis.

Main Research Field

Biology & Biochemistry

Related Research Fields

Chemistry / Molecular Biology & Genetics / Pharmacology & Toxicology / Clinical Medicine

Research Subjects

  • Development of New Diagnosis Method
  • Screening of Novel Drugs
  • Molecular Mechanism of Novel Drugs

Selected Publications

  1. Qin, X-Y., Tatsukawa, H., hitomi, K., Shirakami, Y., Ishibashi, N., Shimizu, M., Moriwaki, H., and Kojima, S.:
    “CE/LC-TOFMS-based metabolic analyses uncovered inhibitory effect of acyclic retinoid on aberrant lipogenesis in mouse diethylnitrosamine-induced hepatic tumorigenesis models.”
    Cancer Prevention Res. in press.(2016)
  2. Shrestha, R., Tatsukawa, H., Shrestha, R., Ishibashi, N., Matsuura, T., Kagechika, H., Kose, S., Hitomi, K., Imamoto, N., and Kojima, S.:
    “Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells.”
    Cell Death & Disease, 6, e2002.(2015)
  3. 123. Hara, M., Inoue, I., Yamazaki, Y., Kirita, A., Matsuura T., Friedman, S., Rifkin, D.B., and Kojima, S.:
    “L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice.”
    Fibrogenesis Tissue Repair 8:17.(2015)
  4. Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Okada M, Sugiyama M, Kojima S, Tanaka Y, Mizokami M, Li J, Tong S, Wakita T.:
    “Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of NTCP expression.”
    J Biol Chem. 290(9):5673-5684.(2015)
  5. Hara, M., Kirita, A., Kondo, W., Matsuura, T., Nagatsuma, K., Dohmae, N., Ogawa, S.,Imajoh-Ohmi, S., Friedman, S. L., Rifkin, D. B., and Kojima, S.:
    “LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis.”
    SpringerPlus 3:221.Doi: 10.1186/2193-1801-3-221 eCollection 2014.(2014)
  6. Qin, X-Y., Wei, F., Tanokura, M., Ishibashi, N., Shimizu, M., Moriwaki, H., and Kojima, S.:
    “The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells.”
    PloS One 8(12):e82860.(2013)
  7. Sakata, K., Hara, M., Terada, T., Watanabe, N., Takaya, D., Yaguchi, S., Matsumoto, T., Matsuura, T., Shirouzu, M., Yokoyama, S., Yamaguchi, T., Miyazawa, K., Aizaki, H., Suzuki, T., Wakita, T., Imoto, M., and Kojima, S.:
    “HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor.”
    Sci. Rep. 3:3243.(2013)
  8. Kuo, TF., Tatsukawa, H., Matsuura, T., Nagatsuma, K., Hirose, S., and Kojima, S.:
    “Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways.”
    J Cell Physiol. 227, 1130-1137.(2012)
  9. Tatsukawa, H., Sano, T., Fukaya, Y., Ishibashi, N., Watanabe, M., Okuno, M., Moriwaki, H., and Kojima, S.:
    “Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.”
    Mol Cancer. 10(4), 11pagesx.(2011)
  10. Tatsukawa, H., Fukaya, Y., Frampton, G., Martinez-Fuentes, A., Suzuki, K., Kuo, T.-F., Nagatsuma, K., Shimokado, K., Okuno, M., Wu, J., lismaa, S., Matsuura, T., Tsukamoto, H., Zern, M. A., Graham, R. M., and Kojima, S.:
    “Role of transglutaminase 2 in liver injury via crosslinking and silencing of transcription factor, Sp1.”
    Gastroenterology 136(5), 1783-1795.(2009)

Lab Members

Principal Investigator

Soichi Kojima
Unit Leader

Core Members

Yutaka Furutani
Research Scientist
Ryutaro Teraoka
Postdoctoral Researcher
Xian-Yang Qin
Postdoctoral Researcher
Senko Tsukuda
Postdoctoral Researcher
Mitsuko Hara
Research Associate
Mengqian Li
International Program Associate
Emi Takano
Technical Staff I
Ikuyo Inoue
Technical Staff 1
Mariko Toguchi
Technical Staff I
Yumi Sato
Technical Staff I
Yukari Matsuba
Assistant
Kimie Tajima
Assistant

Contact information

408 Main Research Building
2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Tel: +81-(0)48-467-7938
Fax: +81-(0)48-462-4675

Email: skojima [at] riken.jp

Related links