Centers & Labs

RIKEN Center for Life Science Technologies

Next-Generation Imaging Team

Team Leader: Yasuyoshi Watanabe (M.D., Ph.D.)
Yasuyoshi  Watanabe(M.D., Ph.D.)

For the advancement of Bio-Function Dynamics Imaging, our mission is to develop next-generation molecular imaging technologies such as the simultaneous multiple-molecular imaging, multi-modal fusion molecular imaging which integrates morphology and physiology, and especially highlighted technology of the GREI (Gamma-Ray Emission Imaging) apparatus. In addition, we will pursue the possibility of the multiple-molecular imaging with PET nuclides.

Main Research Field

Complex systems

Related Research Fields

Environmental science / Interdisciplinary science and engineering / Chemistry / Engineering / Biological Sciences / Agricultural sciences / Medicine, dentistry, and pharmacy

Research Subjects

  • Development of the multiple-molecular imaging apparatus and its application
  • R&D of the multiple-molecular imaging technology with PET nuclides
  • Fusion of molecular imaging science and metallomics research

Selected Publications

  1. Munekane M, Motomura S, Kamino S, Ueda M, Haba H, Yoshikawa Y, Yasui H, Hiromura M, and Enomoto S.:
    "Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI"
    Biochemistry and Biophysics Reports, 5, 211–215 (2016).
  2. Tanioka M, Kamino S, Muranaka A,Ooyama Y, Ota H, Shirasaki Y, Horigome J, Ueda M, Uchiyama M, Sawada D, and Enomoto S.:
    "Reversible Near-Infrared/Blue Mechanofluorochromism of Aminobenzopyranoxanthene"
    J. Am. Chem. Soc., 137 (20), 6436–6439 (2015).
  3. Higashikawa K, Yagi K, Watanabe K, Kamino S, Ueda M, Hiromura M, Enomoto S.:
    "64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues."
    PLoS One, 9(11), e109866 (2014).
  4. Kamino, S., Murakami, M., Tanioka, M., Shirasaki, Y., Watanabe, K., Horigome, J., Ooyama, Y., Enomoto, S.:
    "Design and Syntheses of Highly Emissive Aminobenzopyrano-xanthene Dyes in the Visible and Far-Red Regions"
    Org Lett, 16(1), 258-261 (2014).
  5. Shirasaki Y, Kamino S, Tanioka M, Watanabe K, Takeuchi Y, Komeda S, Enomoto S.:
    "New aminobenzopyranoxanthene-based colorimetric sensor for copper(II) ions with dual-color signal detection system."
    Chem Asian J, 8(11), 2609-2613 (2013).
  6. Motomura S, Kanayama Y, Hiromura M, Fukuchi T, Ida T, Haba H, Watanabe Y, Enomoto S.:
    “Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms”
    J Anal At Spectrom, 28(6), 934-939 (2013).
  7. Taniguchi M, Fukunaka A, Hagihara M, Watanabe K, Kamino S, Kambe T, Enomoto S, Hiromura M.:
    "Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells."
    PLoS One, 8(3), e58022 (2013).
  8. Kamino S, Muranaka A, Murakami M, Tatsumi A, Nagaoka N, Shirasaki Y, Watanabe K, Yoshida K, Horigome J, Komeda S, Uchiyama M, Enomoto S.:
    "A red-emissive aminobenzopyrano-xanthene dye: elucidation of fluorescence emission mechanisms in solution and in the aggregate state."
    Phys Chem Chem Phys, 15(6), 2131-2140 (2013).
  9. Fukunaka A, Kurokawa Y, Teranishi F, Sekler I, Oda K, Ackland ML, Faundez V, Hiromura M, Masuda S, Nagao M, Enomoto S, Kambe T.:
    "Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway."
    J Biol Chem, 286(18), 16363-16373 (2011).
  10. Fukuchi T, Arai Y, Watanabe F, Motomura S, Takeda S, Kanayama Y, Haba H, Watanabe Y, Enomoto S.:
    "A digital signal processing module for Ge semiconductor detectors."
    IEEE Trans Nucl Sci, 58(2), 461-467 (2011).

Lab Members

Principal Investigator

Yasuyoshi Watanabe
Team Leader

Core Members

Shinji Motomura
Deputy Team Leader
Tomonori Fukuchi
Research Scientist

Contact information

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Tel: +81-(0)78-304-7190
Fax: +81-(0)78-304-7191

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