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RIKEN Center for Life Science Technologies

Advanced Solid-State NMR Unit

Unit Leader: Yusuke Nishiyama (Ph.D.)
Yusuke  Nishiyama(Ph.D.)

We develop novel solid-state NMR methods to understand the molecular structures and dynamics in the atomic level and apply these techniques to various materials. We have cutting edge solid-state NMR equipment including ultrafast MAS of 120 kHz and high magnetic fields up to 900 MHz. Our interest includes biomolecules, proteins, peptides, catalysis, pharmaceutical compounds, organic-inorganic hybrid materials, natural minerals etc.

Main Research Field


Related Research Fields

Interdisciplinary science and engineering

Research Subjects

  • solid-state NMR
  • ultrafast MAS solid-state NMR

Selected Publications

  1. Manoj Kumar Pandey, Hiroshi Kato, Yuji Ishii, Yusuke Nishiyama.:
    “Two-dimensional proton-detected 35Cl/1H correlation solid-state NMR experiment under fast magic angle sample spinning: Application to pharmaceutical compounds”
    PhysChemChemPhys, 18 (2016) 6209-6216.
  2. Ann-Christin Pöppler, Jean-Philippe Demers,* Michal Malon, Amit Pratap Singh, Herbert W. Roesky, Yusuke Nishiyama*, Adam Lange*.:
    “Ultra-fast Magic Angle Spinning: Benefits for the Acquisition of Ultra-wideline NMR Spectra of Heavy Spin-½ Nuclei”
    ChemPhysChem, doi: 10.1002/cphc.201501136.
  3. Nishiyama Y, Endo Y, Nemoto T, Bouzier-Sore AK, Wong A.:
    “High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe.”
    Analyst, 140(24), 8097-8100 (2015).
  4. Robertson AJ, Pandey MK, Marsh A, Nishiyama Y, Brown SP.:
    “The use of a selective saturation pulse to suppress t1 noise in two-dimensional 1H fast magic angle spinning solid-state NMR spectroscopy”
    J Magn Reson., 260, 89-97 (2015).
  5. Pandey MK, Nishiyama Y.:
    “Determination of NH proton chemical shift anisotropy with 14N–1H heteronuclear decoupling using ultrafast magic angle spinning solid-state NMR”
    J Magn Reson., 261, 133-140 (2015).
  6. Zhang R, Nishiyama Y, Ramamoorthy A.:
    “Proton-detected 3D 1H/13C/1H correlation experiment for structural analysis in rigid solids under ultrafast-MAS above 60 kHz”
    J Chem Phys., 143(16), 164201 (2015).
  7. Pandey MK, Zhang R, Hashi K, Ohki S, Nishijima G, Matsumoto S, Noguchi T, Deguchi K, Goto A, Shimizu T, Maeda H, Takahashi M, Yanagisawa Y, Yamazaki T, Iguchi S, Tanaka R, Nemoto T, Miyamoto T, Suematsu H, Saito K, Miki T, Ramamoorthy A, Nishiyama Y.:
    “1020MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy.”
    J Magn Reson, 261, 1-5 (2015).
  8. Wickramasinghe A, Wang S, Matsuda I, Nishiyama Y, Nemoto T, Endo Y, Ishii Y.:
    “Evolution of CPMAS under fast magic-angle-spinning at 100kHz and beyond.”
    Solid State Nucl Magn Reson., S0926-2040(15), 30025-4 (2015).
  9. Wang S, Parthasarathy S, Xiao Y, Nishiyama Y, Long F, Matsuda I, Endo Y, Nemoto T, Yamauchi K, Asakura T, Takeda M, Terauchi T, Kainoshogi M, Ishii Y.:
    “Nano-mole scale sequential signal assignment by 1H-detected protein solid-state NMR”
    Chem. Commun., 51, 15055-15058 (2015).
  10. Pandey MK, Nishiyama Y.:
    “Proton-detected 3D 14N/14N/1H isotropic shift correlation experiment mediated through 1H–1H RFDR mixing on a natural abundant sample under ultrafast MAS”
    J Magn Reson., 258, 96-101 (2015).

Lab Members

Principal Investigator

Yusuke Nishiyama
Unit Leader

Core Members

Francois Colaux Henri
Research Associate
Miwa Wakabayashi
Technical Staff I

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

Email: Yusuke.nishiyama [at]

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