Centers & Labs

RIKEN Center for Life Science Technologies

Structural Biology Group

Group Director: Mikako Shirouzu (Ph.D.)
Mikako  Shirouzu(Ph.D.)

We aim to develop novel methods for preparation of biomolecules reflecting their dynamic functional states, and operate an integrated structural analysis pipeline, composed of X-ray crystallography, NMR spectroscopy, cryo-electron microscopy and others. By advancing such technologies and methodologies, we will contribute to “life innovation” such as drug development and medical treatment.
We will establish production methods for huge supramolecular complexes consisting of a number of large components that exist in central particles in biological systems, and develop next-generation technologies for micro/nano-crystal structure analyses using SPring-8 (synchrotron radiation)/SACLA (X-ray Free-Electron Laser). It will lead to establishment of a valuable technology platform for supramolecular structure analysis. Using these technologies, we will elucidate the molecular network of intracellular genes, proteins and RNAs at a three-dimensional structure level.