Centers & Labs

RIKEN Center for Sustainable Resource Science

Advanced Elements Chemistry Research Team

Team Leader: Masanobu Uchiyama (D.Phar.)
Masanobu  Uchiyama(D.Phar.)

In recent years, converting molecules into desired products and synthesizing functional molecules become more important from a viewpoint of establishing the recycling-based society. Our main research aims include 1) development of innovative synthetic processes utilizing common metal elements, 2) molecular design and synthesis toward understanding biological functions such as photosynthesis, and 3) theoretical analysis of reaction mechanisms. We are conducting cutting-edge multidisciplinary research that combines synthetic organic chemistry, spectroscopy, and computational chemistry.

Main Research Field


Related Research Fields

Medicine, dentistry, and pharmacy


  • Organic Chemistry
  • Synthetic Chemistry
  • Elements Chemistry
  • Theoretical Chemistry
  • Pharmaceutical Sciences

Selected Publications

  1. Wang, D.-Y., Kawahata, M., Yang, Z-K., Miyamoto, K., Komagawa, S., Yamaguchi, K., Wang, C.,* and Uchiyama, M.:
    "Stille Coupling via C–N Bond Cleavage"
    Nature. Commun., 7, 12937 (2016).
  2. Tezuka, N., Shimojo, K., Hirano, K.,* Komagawa, S., Yoshida, K., Wang, C., Miyamoto, K., Saito, T., Takita, R., and Uchiyama, M.:
    "Direct Hydroxylation and Amination of Arenes via Deprotonative Cupratio"
    J. Am. Chem. Soc., 138, 9166–9171 (2016).
  3. Sato, H., Teramoto, K., Masumoto, Y., Tezuka, N., Sakai, K., Ueda, S., Totsuka, Y., Shinada, T., Nishiyama, M., Wang, C., Kuzuyama, T., and Uchiyama, M.:
    ""Cation-Stitching Cascade": exquisite control of terpene cyclization in cyclooctatin biosynthesis"
    Sci. Rep. 5, Article number: 18471 (2015).
  4. Otsuka, M., Takita, R., Kanazawa, J., Miyamoto, K., Muranaka, A., and Uchiyama, M.:
    "Conjugation between σ- and π-Aromaticity in 1-C-Arylated Monocarba-closo-dodecaborate Anions"
    J. Am. Chem. Soc. 137, 15082-15085 (2015).
  5. Wang, D.-Y., Wang, C., and Uchiyama, M.:
    "Stannyl-Lithium: A Facile and Efficient Synthesis Facilitating Further Applications"
    J. Am. Chem. Soc. 137, 10488–10491 (2015).
  6. Minami, H., Saito, T., Wang, C., and Uchiyama, M.:
    "Organoaluminum-Mediated Direct Cross-Coupling Reaction"
    Angew. Chem. Int. Ed. 54, 4665-4668 (2015).
  7. Toriumi, N., Muranaka, A., Kayahara, E., Yamago, S., and Uchiyama, M.:
    "In-plane Aromaticity in Cycloparaphenylene Dications: A Magnetic Circular Dichroism and Theoretical Study"
    J. Am. Chem. Soc. 137, 82-85 (2015).
  8. Mizukoshi, Y., Mikami, K., and Uchiyama, M.:
    "Aryne Polymerization Enabling Straightforward Synthesis of Elusive Poly(ortho-arylene)s"
    J. Am. Chem. Soc. 137, 74-77 (2015).
  9. Nagashima, Y., Hirano, K., Takita, R., and Uchiyama, M.:
    "Trans-Diborylation of Alkynes: Pseudo-Intramolecular Strategy Utilizing Propargylic Alcohol Unit"
    J. Am. Chem. Soc. 136, 8532-8535 (2014).
  10. Toriumi, N., Muranaka, A., Hirano, K., Yoshida, K., Hashizume, D., and Uchiyama, M.:
    "18π Tautomeric Benziphthalocyanine: A Functional Near-IR Dye with Tunable Aromaticity"
    Angew. Chem. Int. Ed. 53, 7814-7818 (2014).

Lab Members

Principal Investigator

Masanobu Uchiyama
Team Leader

Core Members

Ryo Takita
Deputy Team Leader
Atsuya Muranaka
Senior Research Scientist
Misae Kanai
Postdoctoral Researcher

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: uchi_yama [at]

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