Centers & Labs

RIKEN Center for Sustainable Resource Science

Chemical Biology Research Group

Group Director: Hiroyuki Osada (D.Agr.)
Hiroyuki  Osada(D.Agr.)

To promote "Chemical Biological Research" that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries.

Our group constructs chemical libraries through the genetic engineering of microorganisms and organic synthesis, and databases that describe the chemical and biological information of the libraries.

We explore the useful bioactive compounds in the chemical library and identify the molecular targets of bioactive compounds, and elucidate the mechanisms behind the actions of the active compounds as well.

We continue to maintain the infrastructure for advanced studies of chemical biology and sustainable resource science.

Main Research Field

Complex systems

Related Research Fields

Interdisciplinary science and engineering / Biology

Keywords

  • Chemical Biology
  • Natural Products Depository
  • Chembioinformatics
  • Isolation and Synthesis of Bioactive Compounds
  • Analysis of Protein-Small Molecule Interaction

Selected Publications

  1. Otaka, J., Hashizume, D., Masumoto, Y., Muranaka, A., Uchiyama, M., Koshino, H., Futamura, Y., and Osada, H.:
    "Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea."
    Org Lett. [Epub ahead of print] (2017).
  2. Nogawa, T., Okano, A., Lim, C.L., Futamura, Y., Shimizu, T., Takahashi, S., Ibrahim, D., and Osada H.:
    "Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355."
    J Antibiot, 70, 222-225 (2017).
  3. Kawatani, M., Muroi, M., Wada, A., Inoue, G., Futamura, Y., Aono, H., Shimizu, K., Shimizu, T., Igarashi, Y., Takahashi-Ando, N., and Osada, H.:
    "Proteomic profiling reveals that collismycin A is an iron chelator"
    Sci Rep, 6, 38385 (2016).
  4. Hasebe, F., Matsuda, K., Shiraishi, T., Futamura, Y., Nakano, T., Tomita, T., Ishigami, K., Taka, H., Mineki, R., Fujimura, T., Osada, H., Kuzuyama, T., and Nishiyama, T.:
    "Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces"
    Nat Chem Biol, 12, 967–972 (2016).
  5. Kondoh, Y., Honda, K., Hiranuma, S., Hayashi, T., Shimizu, T., Watanabe, N., and Osada, H.:
    "Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ."
    Sci Rep, 6, 29881 (2016).
  6. Yun C.S., Motoyama T., and Osada H.:
    "Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme"
    Nat. Commun. 6, 8758 (2015).
  7. Soeda Y., Yoshikawa M., Almeida O.F., Sumioka A., Maeda S., Osada H., Kondoh Y., Saito A., Miyasaka T., Kimura T., Suzuki M., Koyama H., Yoshiike Y., Sugimoto H., Ihara Y., and Takashima A.:
    "Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups"
    Nat. Commun. 6, 10216 (2015).
  8. Kawamura T., Kondoh Y., Muroi M., Kawatani M.,and Osada H.:
    "A small molecule that induces reactive oxygen species via cellular glutathione depletion"
    Biochem. J. 463, 53-63 (2014).
  9. Futamura Y., Kawatani M., Muroi M., Aono H., Nogawa T., and Osada H.:
    "Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems"
    ChemBioChem 14, 2456-2463 (2013).
  10. Motoyama T., Hayashi T., Hirota H., Ueki M., and Osada H.:
    "Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba"
    Chem. Biol., 19, 1611-1619 (2012).

Lab Members

Principal Investigator

Hiroyuki Osada
Group Director

Core Members

Makoto Muroi
Senior Research Scientist
Takayuki Motoyama
Senior Research Scientist
Yasumitsu Kondoh
Senior Research Scientist
Makoto Kawatani
Senior Research Scientist
Takeshi Shimizu
Senior Research Scientist
Toshihiko Nogawa
Research Scientist
Yushi Futamura
Research Scientist
Choong Soo Yun
Research Scientist
Junnosuke Otaka
Special Postdoctoral Researcher
Ikuko Nagasawa
Special Postdoctoral Researcher
Kazuko Yoshida
Postdoctoral Researcher
Julius Lopez
Postdoctoral Researcher
Sho Kato
Junior Research Associate
Kai Yamamoto
Junior Research Associate
Mira Syahfriena Binti Amir Rawa
International Program Associate
Harumi Aono
Technical Staff I
Akiko Okano
Technical Staff I
Reiko Sato
Technical Staff I
Aiko Hiraki
Technical Staff II

Contact information

Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama
351-0198, Japan
Tel: +81-(0)48-467-9541
Fax: +81-(0)48-462-4669

Email: hisyo [at] riken.jp

Related links

Recent research results

October 27, 2015: Press Release
Secrets of a rice-killing fungal toxin