Centers & Labs

RIKEN Center for Sustainable Resource Science

Chemical Resource Development Research Unit

Unit Leader: Hiroyuki Osada (D.Agr.)
Hiroyuki  Osada(D.Agr.)

Chemical library is one of the indispensable tools to promote the research on regulation of cell functions and drug-discovery with the strategy of chemical biology. To ensure utilization and application of the chemical library, we promote research supports in chemical biology and resource science by provision of chemical compounds, their information and structure-activity relationship analysis. Moreover we will enrich the chemical library by cooperation with Chemical Biology Research Group and Natural Product Biosynthesis Research Unit.

Main Research Field

Complex systems

Related Research Fields

Informatics / Biological Sciences / Agricultural sciences / Medicine, dentistry, and pharmacy

Keywords

  • Chemical Biology
  • Natural Products Depository
  • Chembioinformatics
  • Chemical Library

Selected Publications

  1. Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilso E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, Leeuwen Jv, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL & Boone C.
    "Functional annotation of chemical libraries across diverse biological processes."
    Nat. Chem. Biol., in press (2017).
  2. Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Ohno H, Osada H & Fujii N:
    "Screening of a virtual mirror-image library of natural products."
    Chem. Commun., 52, 7653-7656 (2016).
  3. Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, & Harada A:
    "Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells."
    J. Cell Biol., 215, 121-138 (2016).
  4. Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H & Suzu S:
    "Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages."
    J. Immunol., 196: 1832-1841 (2016).
  5. Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, Tsunetsugu-Yokota Y, Suzuki M & Aida Y:
    "Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor."
    PLoS One, 10: e0145573 (2015).
  6. Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y & Takashima A:
    "Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups."
    Nat. Commun., 6: 10216 (2015).
  7. Kakisaka M, Sasaki Y, Yamada K, Kondoh Y, Hikono H, Osada H, Tomii K, Saito T & Aida Y:
    "A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein."
    PLoS Pathog., 11: e1005062 (2015).
  8. Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS & Osada H:
    "RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270."
    J. Antibiot., 68: 293-295 (2015).
  9. Choi SB, Choong YS, Saito A, Wahab HA, Najimudin N, Watanabe N, Osada H & Ong EBB:
    "In silico investigation of a HIV-1 Vpr inhibitor binding site: potential for virtual screening and anti-HIV drug design."
    Mol. Inform., 11: 742-748 (2014).
  10. Maeda K, Nakajima Y, Motoyama T, Kitou Y, Kosaki T, Saito T, Nishiuchi T, Kanamaru K, Osada H, Kobayashi T & Kimura M:
    "Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi."
    Lett. Appl. Microbiol., 59: 377-383 (2014).

Lab Members

Principal Investigator

Hiroyuki Osada
Unit Leader

Core Members

Yuta Iwai
Technical Staff II
Hiroyuki Hirano
Technical Staff II

Contact information

Chemical Biology Bldg,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan
Tel: +81-(0)48-467-4839
Fax: +81-(0)48-462-1353

Email: npdepo [at] riken.jp

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