Centers & Labs

RIKEN Center for Sustainable Resource Science

Chemical Bank Unit for Drug Discovery Platform

Unit Leader: Hiroyuki Osada (D.Agr.)
Hiroyuki  Osada(D.Agr.)

Our unit takes the role of chemical bank in DMP; we store compounds synthesized or purchased in the process of exploration and structure optimization of drugs and supply them for the purpose of validation of biological activity, toxicity or safety. In cooperation with Chemical Resource Development Research Unit, we also construct and provide a chemical library for drug-discovery screening to the Seed Compounds Exploratory Unit for Drug Discovery Platform and other researchers. We have constructed the database for management of chemical library to provide compounds efficiently.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Informatics / Biological Sciences

Research Subjects

  • Storage of chemical libraries for drug-discovery
  • Provision of chemical libraries for HTS to explore drug seeds
  • Construction of database for management of chemical library

Selected Publications

  1. Hashimoto M., Bhuyan F., Hiyoshi M., Noyori O., Nasser H., Miyazaki M., Saito T., Kondoh Y., Osada H., Kimura S., Hase K., Ohno H., Suzu S.:
    "Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages."
    J Immunol, 196, 1832-1841 (2016)
  2. Soeda Y., Yoshikawa M., Almeida OF., Sumioka A., Maeda S., Osada H., Kondoh Y., Saito A., Miyasaka T., Kimura T., Suzuki M., Koyama H., Yoshiike Y., Sugimoto H., Ihara Y., Takashima A.:
    "Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups."
    Nat Commun, 6, 10216 (2015)

Lab Members

Principal Investigator

Hiroyuki Osada
Unit Leader

Core Members

Yasumitsu Kondoh
Deputy Unit Leader
Takeshi Shimizu
Senior Research Scientist
Hiroyuki Hirano
Technical Staff I
Yuta Iwai
Technical Staff II

Contact information

Chemical Biology Bldg., 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: npdepo [at] riken.jp