Centers & Labs

RIKEN Center for Sustainable Resource Science

Drug Discovery Seed Compounds Exploratory Unit

Unit Leader: Minoru Yoshida (D.Agr.)
Minoru  Yoshida(D.Agr.)

The mission of the Seed Compounds Exploratory Unit is to contribute to searching for active compound candidates (hit compounds) for drug targets through high throughput screening (HTS) from compound libraries and, further, to identifying hit compounds (true hits) that truly act on the targets.

Main Research Field


Related Research Fields



  • Chemical Biology
  • Epigenetics
  • Mode of Action
  • Transcriptional Regulation
  • Chemical Screening for Drug Discovery

Selected Publications

  1. Yoshida, M., Kudo, N., Kosono, S., Ito, A.
    "Chemical and structural biology of protein lysine deacetylases."
    Proc Jpn Acad Ser B Phys Biol Sci. 93(5), 297-321 (2017)
  2. Feldman, J.L., Dittenhafer-Reed, K.E., Kudo, N., Thelen, J.N., Ito, A., Yoshida, M., Denu, J.M.:
    "Kinetic and structural analysis of acyl-group selectivity provides insight into Sirtuin-catalyzed deacylation."
    Biochemistry 54(19), 3037-3050 (2015).
  3. Hirohama, M., Kumar, A., Fukuda, I., Matsuoka, S., Igarashi, Y., Saitoh, H., Takagi, M., Shin-Ya, K., Honda, K., Kondoh, Y., Saito, T., Nakao, Y., Osada, H., Zhang, K.Y., Yoshida, M., Ito, A.:
    "Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2."
    ACS Chem. Biol. 8(12), 2635-42 (2013).
  4. Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H., and Yoshida, M.:
    "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor."
    Biochem. Biophys. Res. Commun. 394, 569-573 (2010).

Lab Members

Principal Investigator

Minoru Yoshida
Unit Leader

Core Members

Tetsuo Onuki
Deputy Unit Leader
Kenji Ogawa
Senior Research Scientist
Ken Matsumoto
Senior Research Scientist
Norio Kudo
Research Scientist
Kousiki Mino
Research Scientist
Hiroki Kobayashi
Research Scientist
Satoko Maeda
Technical Staff I
Iku Kuwahara
Technical Staff I
Michiru Iwashita
Technical Staff I
Haruna Nishimura
Technical Staff I
Mari Agawa
Technical Staff I
Seiji Matsuoka
Technical Staff I
Mayumi Arata
Technical Staff I
Yui Kashima
Technical Staff I
Takeshi Sonoda
Technical Staff I
Akiko Nakata
Technical Staff II
Yui Mazaki
Technical Staff II
Yasue Ichikawa
Technical Staff II
Taeko Wakana
Technical Staff II