Centers & Labs

RIKEN Center for Sustainable Resource Science

Environmental Metabolic Analysis Research team

Team Leader: Jun Kikuchi (Ph.D.)
Jun  Kikuchi(Ph.D.)

Our team intends for development of novel environmental analysis such as bird-eye viewing of metabolism caused by ecosystem biodiversity, based on technical advancements of our NMR approaches toward metabolite and biomass mixtures, as well as inorganic elements and microbial ecosystem analyses combined with bioinformatics and chemoinformatics approach. Namely, we promote both international and industrial collaboration in order to contribute for effective utilization of chemical resources, by analyzing laboratory systems, industrial (agriculture, forestry, fishery) process, and natural environment (hydro- and landsphere, as well as outer space).

Main Research Field

Complex systems

Related Research Fields

Informatics / Environmental science / Chemistry / Biological Sciences

Research Subjects

  • Methodology development of data mining and accumulation of databases for environmental analysis
  • Sustainable utilization of land- and aquatic biomass based on studies of natural environmental purification system
  • Symbiotic metabonomic analysis between animals (both aquatic and terrestrial) and symbiotic microbiota in relation to their food nutrients

Selected Publications

  1. Komatsu, T., Ohishi, R., Shino, A. and Kikuchi, J.*:
    "Structure and metabolic flow analysis of molecular complexity in 13C-labeled tree by 2D and 3D-NMR"
    Angew. Chem. Int. Ed. (in press) Doi:10.1002/anie.201600334.
  2. Kikuchi, J.* Tsuboi, Y., Komatsu, K., Gomi, M., Chikayama, E. and Date, Y.:
    "SpinCouple: Development of web-tool for analyzing metabolite mixtures via 2D-J resolved NMR spectra"
    Anal. Chem. 88, 659-665 (2016).
  3. Komatsu, T., Kobayashi, T., Hatanaka, M. and Kikuchi, J.*:
    "Profiling planktonic biomass using element-specific, multicomponent nuclear magnetic resonance spectroscopy"
    Environ. Sci. Technol. 49, 7056-7062 (2015).
  4. Tokuda, T., Tsuboi, Y., Kihara, K. Saito, S. Moriya, S. Lo, N. and Kikuchi, J.*:
    "Metabolomic profiling of 13C-cellulose digestion in a lower termite: insights into symbiont function"
    Proc. Royal Soc. B. 281, 20140990 (2014).
  5. Yoshida, S., Akama, K., Date, Y. and Kikuchi, J.*:
    "Comparative metabolomic and ionomic approach for abundant fishes in estuarine environments of Japan"
    Sci. Rep. 4, 7005 (2014).
  6. Ito, K., Sakata, K., Date, Y. and Kikuchi, J.*:
    "Integrated analysis of seaweed components in seasonal fluctuation by data mining across heterogeneous chemical measurements with network visualization"
    Anal. Chem. 86, 1098-1105 (2014).
  7. Asakura, T., Date, Y. and Kikuchi, J.*:
    "Comparative analysis of chemical and microbial profiles of estuarine sediments sampled from Kanto and Tohoku regions in Japan"
    Anal. Chem. 86, 5425-5432 (2014).
  8. Furusawa, Y., Obata, Y., Fukuda, S.*, Endo, T., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M., Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K.* and Ohno, H*:
    "Commensal microbe-derived butyrate induces colonic regulatory T cells"
    Nature 504, 446-450 (2013).
  9. Komatsu, T. and Kikuchi, J.*:
    "Selective signal detection in solid-state NMR using rotor synchronized dipolar dephasing for the analysis of hemicellulose in lignocellulosic biomass"
    J. Phys. Chem. Lett. 4, 2279-2283 (2013).
  10. Fukuda, S., Toh, H., Hase, K., Nakanishi, Y., Oshima, K., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M.* and Ohno, H.*:
    "Bifidobacteria protect from enteropathogenic infection through production of acetate."
    Nature 469, 543-547 (2011).

Lab Members

Principal Investigator

Jun Kikuchi
Team Leader

Core Members

Yasuhiro Date
Research Scientist
Feifei Wei
Postdoctoral Researcher
Mario Uchimiya
Visiting Researcher
Yuuri Tsuboi
Technical Staff I
Amiu Shino
Technical Staff I
kenji Sakata
Technical Staff I
Tomoko Matsumoto
Technical Staff II
Keiko Komatsu
Technical Staff II

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan
Tel: +81-(0)45-503-9490
Fax: +81-(0)45-503-9489

Email: jun.kikuchi [at] riken.jp

Related links

Recent research results

June 17, 2016: Press Release
Torrefied biomass improves poor soil

Further information