Centers & Labs

RIKEN Center for Sustainable Resource Science

Metabolome Informatics Research Team

Team Leader: Masanori Arita (D.Sci.)
Masanori  Arita(D.Sci.)

Our team develops software platforms necessary for metabolomic analyses, network analyses and computer simulations. We also design databases that help more efficient identification of metabolites. The developed software will be applied to integrated analysis of metabolomic and transcriptomic data collated by other teams to enable systematic understanding of plants.

Main Research Field

Complex systems

Related Research Fields

Biological Sciences

Research Subjects

  • Statistical analysis and interpretation of metabolomics data
  • Development of software for metabolic network analyses and simulations
  • Construction of metabolic databases

Selected Publications

  1. Tsugawa H, Cajka T, Kind T, Ma Y, Higgins B, Ikeda K, Kanazawa M, VanderGheynst J, Fiehn O, Arita M:
    "MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis"
    Nature Methods 12(6), 523-526, 2015
  2. Fukushima A, Nakamura M, Suzuki H, Saito K, Yamazaki M:
    "High-Throughput Sequencing and De Novo Assembly of Red and Green Forms of the Perilla frutescens var. crispa Transcriptome"
    PLOS One 10(6), e0129154, 2015
  3. Hasegawa Y, Arita M:
    "Optimal implementations for reliable circadian clocks"
    Physical Review Letters 113(10), 108101, 2014
  4. Fukushima A, Kusano M.:
    "Recent progress in the development of metabolome databases for plant systems biology"
    Front Plant Sci, 4(73), 2013
  5. Fukushima A.:
    "DiffCorr: an R package to analyze and visualize differential correlations in biological networks"
    Gene, 518(1), 209-214, 2013
  6. Tsugawa H, Arita M, Kanazawa M, Ogiwara A, Bamba T, Fukusaki E.:
    "MRMPROBS: a data assessment and metabolite identification tool for large-scale multiple reaction monitoring based widely targeted metabolomics"
    Anal Chem, 85(10), 5191-5199, 2013
  7. Tsugawa H, Tsujimoto Y, Sugitate K, Sakui N, Nishiumi S, Bamba T, Fukusaki E.:
    "Highly sensitive and selective analysis of widely targeted metabolomics using gas chromatography/triple-quadrupole mass spectrometry"
    J Biosci Bioeng, 117(1), 122-128, 2013
  8. Hasegawa Y, Arita M.:
    "Enhanced entrainability of genetic oscillators by period mismatch"
    J R Soc Interface. 2013 Feb 6;10(81):20121020
  9. Hasegawa Y, Arita M.:
    "Enhanced entrainability of genetic oscillators by period mismatch"
    J R Soc Interface, 10(81), 20121020, 2013
  10. Hasegawa Y, Arita M.:
    "Circadian clocks optimally adapt to sunlight for reliable synchronization"
    J R Soc Interface, 11(92), 20131018, 2012

Lab Members

Principal Investigator

Masanori Arita
Team Leader

Core Members

Atsushi Fukushima
Research Scientist
Hiroshi Tsugawa
Postdoctoral Researcher
Ramon Francisco Pacquiao Mejia
Postdoctoral Researcher

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan

Email: Masanori.arita [at]

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