Centers & Labs

RIKEN Center for Sustainable Resource Science

RIKEN-KRIBB Joint Research Unit

Unit Leader: Shunji Takahashi (D.Sci.)
Shunji  Takahashi(D.Sci.)

This team is collaborating with the Chemical Biology Research Center of KRIBB directed by Dr. Jong Seog Ahn on the integrative research of bioactive compounds derived from microorganisms. The goal of this joint team is the discovery of drug candidate compounds through the chemical biology research from the chemical studies such as screening, isolation and structure determination to the biological studies such as biosynthesis, evaluation of biological activity, and the understanding of the mechanism of action. Exchange and long-term stay of researchers will promote the formation of a human network.

Main Research Field

Complex systems

Related Research Fields

Interdisciplinary science and engineering / Biological Sciences

Research Subjects

  • Target identification of bioactive compounds
  • Screening and isolation of novel bioactive microbial products

Selected Publications

  1. Jang, J.-P, Nogawa, T., Futamura, Y., Shimizu, T., Hashizume, D., Takahashi, S., Jang J.-H., Ahn, J.S., and Osada, H.:
    "Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum."
    J. Nat. Prod., 80, 134-140 (2017).
  2. Jang, J.-P, Takahashi, S., Futamura, Y., Nogawa, T., Jang, J.-H., Ahn, J.S., and Osada, H.:
    "RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441."
    J. Antibiot., 70, 102-104 (2017).
  3. Kim, J., Ko, S.-K., Kim, H.-M., Kim, G.H., Son, S., Kim, G.S., Hwang, G.J., Jeon, E.S., Shin, K.-S., Ryoo, I,-J., Hong, Y.-S., Oh, H., Lee, K.H., Soung, N.K., Hashizume, D., Takahashi, S., Kim, B.Y., Osada, H. Jang, J.-H., Ahn, J.S.:
    "Stachybotrysin, an osteoclast differentiation inhibitor from a marine-derived fungus Stachybotrys sp. KCB13F013."
    J. Nat. Prod., 79, 2703-2708 (2016).
  4. Kato, N., Nogawa, T., Hirota, H., Jang, J.-H., Takahashi, S., Ahn, J.S., Osada, H.:
    "A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis."
    Biochem. Biophys. Res. Commun. 460, 210-215 (2015).
  5. Kim, J.W., Ko, S.-K., Son, S., Shin, K.-S., Ryoo, I.-J., Hong, Y.-S., Oh, H., Hwang, B.Y., Hirota, H., Takahashi, S., Kim B.Y., Osada, H., Jang, J.H., Ahn, J.S.:
    "Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005."
    Bioorg. Med. Chem. Lett. 25, 5398-5401 (2015).
  6. Jang, J.-P., Nogawa, T., Uramoto, M., Okano, A., Futamura, Y., Shimizu, T., Takahashi, S., Jang, J.-H., Ahn, J.S., and Osada, H.:
    "RK270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270."
    J. Antibiot. 68, 293-295 (2015).
  7. Oh, M., Jang, J.-H., Choo, S.-J., Kim, S.-O., Kim, J.W., Ko, S.-K., Soung, N.-K., Lee, J.-S., Kim, C.-J., Oh, H., Hong, Y.-S., Ueki, M., Hirota, H., Osada, H., Kim, B.Y., and Ahn, J.S.:
    "Boseongazepines A-C, Pyrrolobenzodiazepine Derivatives from a Streptomyces sp. 11A057."
    Bioorg. Med. Chem. Lett. 24, 1802-1804 (2014).
  8. Asami, Y., Jang, J.-H., Soung, N.-K., He, L., Moon, D.O., Kim, J.W., Oh, H., Muroi, M., Osada, H., Kim, B.Y., and Ahn, J.S.:
    "Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells."
    Bioorg. Med. Chem. 20, 3799-3806 (2012).
  9. Asami, Y., Jang, J.-H., Oh, H., Sohn, J.H., Kim, J.W., Moon, D.O., Kwon, O., Kawatani, M., Osada, H., Kim, B.Y., and Ahn, J.S.:
    "Violaceols function as actin inhibitors inducing cell shape elongation in fibroblast cells."
    Biosci. Biotechnol. Biochem. 76, 1431-1437 (2012).
  10. Jang, J.-H., Asami, Y., Jang, J.-P., Kim, S.O., Moon, D.O., Shin, K.S., Hashizume, D., Muroi, M., Saito, T., Oh, H., Kim, B.Y., Osada, H., and Ahn, J.S.:
    "Fusarisetin A, an Acinar Morphogenesis inhibitor from a soil fungus, Fusarium sp. FN0180326."
    J. Am. Chem. Soc, 133, 6865-6867 (2011).

Lab Members

Principal Investigator

Shunji Takahashi
Unit Leader

Core Members

Naoki Kato
Research Scientist
Toshihiko Nogawa
Research Scientist

Contact information

Chemical Biology Building,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan

Email: shunjitaka [at] riken.jp