Centers & Labs

RIKEN Center for Sustainable Resource Science

Bioprobe Research Group

Group Director: Hiroyuki Osada (D.Agr.)
Hiroyuki  Osada(D.Agr.)

In collaboration with a group of Max Planck Institute (MPI) of Molecular Physiology (group of Prof. Herbert Waldmann), Dortmund, Germany, we perform chemical biology study. We exchange young researchers each other for the tight and continuous collaboration.

Main Research Field

Complex systems

Related Research Fields

Interdisciplinary science and engineering / Biological Sciences

Research Subjects

  • Target identification of bioactive compounds

Selected Publications

  1. Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang M., Brockmeyer, A, Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schöler, H.R., and Waldmann, H.:
    "Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1."
    Cell Chem Biol. 23, 494-507 (2016)
  2. Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.:
    "Proteomic profiling reveals that collismycin A is an iron chelator."
    Sci Rep, 6, 38385 (2016)
  3. Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.:
    "Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival."
    Sci Rep, 6, 26521 (2016)
  4. Muroi M, Futamura Y, Osada H.:
    "Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase."
    Nat Prod Rep, 33, 621-625 (2016)
  5. Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.:
    "A small molecule that induces reactive oxygen species via cellular glutathione depletion."
    Biochem J, 463, 53-63 (2014)

Lab Members

Principal Investigator

Hiroyuki Osada
Group Director

Core Members

Miho Tanaka
Technical Staff I
Makoto Muroi
Senior Research Scientist

Contact information

Chemical Biology Building,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan

Email: hisyo [at] riken.jp