Centers & Labs

Global Research Cluster

Disease Glycomics Team

Team Leader: Naoyuki Taniguchi (M.D., Ph.D.)
Naoyuki  Taniguchi(M.D., Ph.D.)

Most of membrane receptors such as growth factor receptors are glycoproteins but the roles of their glycans are not fully understood. Our laboratory aims to explore the roles of glycans in the development and differentiation under physiological conditions as well as in the life style-related diseases such as COPD, Alzheimer’s disease, cancer and demyelinating disease. We also focus on basic research in order to develop new biomarkers and therapeutics using glycans for these diseases.

Main Research Field

Biology & Biochemistry

Related Research Fields

Molecular Biology & Genetics / Immunology / Neuroscience & Behavior

Research Subjects

  • Glycan signals and glycan-based therapeutics in COPD
  • Role of glycans in Alzheimer's disease
  • Expression of a brain specific glycan and its role in demyelination
  • Role of glycans in angiogenesis
  • Disease biomarkers

Selected Publications

  1. Taniguchi N, and Kizuka Y.:
    "Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics."
    Adv Cancer Res. 126:11-51(2015)
  2. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N.:
    "An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease."
    EMBO Mol Med. 15;7(2):175-89. (2015)
  3. Kitazume S, Imamaki R, Kurimoto A, Ogawa K, Kato M, Yamaguchi Y, Tanaka K, Ishida H, Ando H, Kiso M, Hashii N, Kawasaki N and Taniguchi N.:
    "Interaction of platelet endothelial cell adhesion molecule (PECAM) with α2,6-sialylated glycan regulates its cell surface residency and anti-apoptotic role."
    J Biol Chem., 289(40):27604-27613 (2014)
  4. Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor EM and Taniguchi N.:
    "Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers."
    J Biol Chem., 289(16):11253-11261 (2014)
  5. Kurimoto A, Kitazume S, Kizuka Y, Nakajima K, Oka R, Fujinawa R, Korekane H, Yamaguchi Y, Wada Y and Taniguchi N.:
    "The absence of core fucose upregulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function."
    J Biol Chem., 289(17):11704-11714 (2014)
  6. Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I and Taniguchi N.:
    "Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb)."
    J. Biol. Chem., 288(39): 27912-27926 (2013)
  7. Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, Maeno T, Kitazume S, Yoshida K, Ishii T, Gao C, Ohtsubo K, Yamaguchi Y, Betsuyaku T, Kida K and Taniguchi N.:
    "A Single Dose of LPS into Mice with Emphysema Mimics Human COPD Exacerbation as Assessed by Micro-CT."
    Am. J. Respir. Cell Mol. Biol., 9(6):971-977 (2013)
  8. Kanekiyo K, Inamori K, Kitazume S, Sato K, Maeda J, Higuchi M, Kizuka Y, Korekane H, Matsuo I, Honke K and Taniguchi N.:
    "Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination."
    J. Neurosci., 33(24): 10037-10047 (2013)
  9. Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K and Taniguchi N.:
    "Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol."
    Life Sci., 70(17): 3199-3210 (2013)
  10. Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N and Taniguchi N.:
    "Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome."
    J. Biol. Chem., 287(48): 40817-40825 (2012)

Lab Members

Principal Investigator

Naoyuki Taniguchi
Team Leader

Core Members

Shinobu Kitazume
Deputy Team Leader
Congxiao Gao
Research Scientist
Yuriko Tachida
Technical Scientist
Yasuhiko Kizuka
Special Postdoctoral Researcher
Junko Iijima
Postdoctoral Researcher
Kanoko Sakuda
Junior Research Associate
Emi Ito
Technical Staff I
Reiko Fujinawa
Technical Staff I
Rie Imamaki
Technical Staff I
Fumi Ota
Technical Staff I
Keiichi Yoshida
Technical Staff II
Izumi Funayama
Assistant
Akemi Suzuki
Part-timer 2
Kazuko Ogawa
Part-timer 2
Ritsuko Oka
Part-time Worker
Keiko Sato
Part-timer 2

Contact information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: tani52 [at] wd5.so-net.ne.jp

Recent research results