Centers & Labs

Global Research Cluster

Disease Glycomics Team

Team Leader: Naoyuki Taniguchi (M.D., Ph.D.)
Naoyuki  Taniguchi(M.D., Ph.D.)

Most of membrane receptors such as growth factor receptors are glycoproteins but the roles of their glycans are not fully understood. Our laboratory aims to explore the roles of glycans in the development and differentiation under physiological conditions as well as in the life style-related diseases such as COPD, Alzheimer’s disease, cancer and demyelinating disease. We also focus on basic research in order to develop new biomarkers and therapeutics using glycans for these diseases.

Main Research Field

Biological Sciences

Related Research Fields

Biology / Medicine, dentistry, and pharmacy

Keywords

  • glycoproteins
  • Chronic Obstructive Pulmonary Disease
  • Alzheimer's disease
  • cancer
  • GnT-III

Selected Publications

  1. Kaburagi T, Kizuka Y, Kitazume S, and Taniguchi N.
    "Inhibitory Role of α2,6-Sialylation in Adipogenesis."
    J. Biol. Chem 10;292(6):2278-2286. (2017)
  2. Kizuka Y, Funayama S, Shogomor H, Nakano M, Nakajima K, Oka R, Kitazume S, Yamaguchi Y, Sano M, Korekane H, Hsu T-L, Lee H-Y, Wong C-H and Taniguchi N.
    "Novel Fucose Analog for the High-sensitive Detection of Glycans."
    Cell Chem. Biol. 23, 782-92. (2016)
  3. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N.:
    "An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease."
    EMBO Mol Med. 15;7(2):175-89. (2015)
  4. Kitazume S, Imamaki R, Kurimoto A, Ogawa K, Kato M, Yamaguchi Y, Tanaka K, Ishida H, Ando H, Kiso M, Hashii N, Kawasaki N and Taniguchi N.:
    "Interaction of platelet endothelial cell adhesion molecule (PECAM) with α2,6-sialylated glycan regulates its cell surface residency and anti-apoptotic role."
    J Biol Chem., 289(40):27604-27613 (2014)
  5. Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor EM and Taniguchi N.:
    "Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers."
    J Biol Chem., 289(16):11253-11261 (2014)
  6. Kurimoto A, Kitazume S, Kizuka Y, Nakajima K, Oka R, Fujinawa R, Korekane H, Yamaguchi Y, Wada Y and Taniguchi N.:
    "The absence of core fucose upregulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function."
    J Biol Chem., 289(17):11704-11714 (2014)
  7. Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I and Taniguchi N.:
    "Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb)."
    J. Biol. Chem., 288(39): 27912-27926 (2013)
  8. Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, Maeno T, Kitazume S, Yoshida K, Ishii T, Gao C, Ohtsubo K, Yamaguchi Y, Betsuyaku T, Kida K and Taniguchi N.:
    "A Single Dose of LPS into Mice with Emphysema Mimics Human COPD Exacerbation as Assessed by Micro-CT."
    Am. J. Respir. Cell Mol. Biol., 9(6):971-977 (2013)
  9. Kanekiyo K, Inamori K, Kitazume S, Sato K, Maeda J, Higuchi M, Kizuka Y, Korekane H, Matsuo I, Honke K and Taniguchi N.:
    "Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination."
    J. Neurosci., 33(24): 10037-10047 (2013)
  10. Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K and Taniguchi N.:
    "Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol."
    Life Sci., 70(17): 3199-3210 (2013)

Lab Members

Principal Investigator

Naoyuki Taniguchi
Team Leader

Core Members

Shinobu Kitazume
Deputy Team Leader
Yasuhiko Kizuka
Research Scientist
Yuriko Tachida
Visiting Scientist
Kanoko Sakuda
Junior Research Associate
Rie Imamaki
Technical Staff I
Fumi Ota
Technical Staff I
Keiichi Yoshida
Technical Staff II
Izumi Funayama
Assistant
Akemi Suzuki
Part-timer 2
Kazuko Ogawa
Part-timer 2
Ritsuko Oka
Part-time Worker
Keiko Sato
Part-timer 2