Research Summary

Selected Publications

• 1.Ishigaki, K., Kochi, Y., Suzuki, A., Yamaguchi, K., ,Yamamoto, K et al.:
  “Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis”
  Nature Genetics. 49, 1120-1125 (2017)
• 2.Sun, C, Molineros, JE, Looger, LL et al.:
  “High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.”
  Nature Genetics, 48:323-330 (2016)
• 3.Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM.:
  “Genetics of rheumatoid arthritis contributes to biology and drug discovery”
  Nature ,506 (7488), 376-381 (2014）
• 4.Okada, Y, Terao, C, Yamamoto, K, et al.:
  “Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.”
  Nature Genetics, 44 (5): 511-6 (2012)
• 5.Okada, Y, Shimane, K, Yamamoto, K, et al.:
  “A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Erythematosus in Japanese”
  Plos Genetics, 8(1):e1002455 (2012)
• 6.Kochi, Y, Okada, Y, Suzuki, A, et al.:
  “A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.”
  Nature Genetics, 42 (6): 515-9 (2010)
• 7.Shimane, K,　Kochi, Y, Yamamoto, K., et al.:
  “A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.”
  Annals of Rheumatic Diseases, 68(3), 377-383 (2009)
• 8.Suzuki, A, Yamada, R, Yamamoto, K., et al.:
  “Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population.”
  Nature Genetics, 40(10), 1224-1229 (2008)
• 9.Kochi Y, Yamada, R, Yamamoto, K., et al.:
  “A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.”
  Nature Genetics, 37(5), 478-485 (2005)
• 10.Suzuki, A., Yamada, R., Yamamoto, K., et al.:
  “Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis”
  Nature Genetics, 34(4), 395-402 (2003)

Recent Research Results

• 

  Aug. 18, 2017
  Mapping disease genes to immune cells

• 

  Dec. 26, 2013
  Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery

Related Links

Lab Members

Contact Information

E508,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: kazuhiko.yamamoto [at] riken.jp