Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Cardiovascular Diseases

Team Leader: Kaoru Ito (M.D., Ph.D)
Kaoru  Ito(M.D., Ph.D)

Because heart diseases represent more than 15% of the cause of death in Japanese population and more than 20% of total medical expenses in Japan, it is socially important to reveal mechanismof these disorders. This laboratory focuses on cardiovascular diseases including myocardial infarction, atrial fibrillation, Kawasaki disease, to obtain useful information in clinical fields by genomic analyses. In addition, we work on developing new approaches to tackle with those diseases using machine learning techniques and high-throughput multi-omics technologies that are growing enormously in recent years.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Biology & Biochemistry / Clinical Medicine

Research Subjects

  • Identification and functional analyses of genes related to cardiovascular Diseases
  • Identification and functional analyses of genes related to Kawasaki disease
  • Development of novel methods for functional analysis using omics and high-throughput sequencing technologies

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Konta A, Ozaki K, Sakata Y, Takahashi A, Morizono T, Suna S, Onouchi Y, Tsunoda T, Kubo M, Komuro I, Eishi Y, Tanaka T.:
    "A functional SNP in FLT1 increases risk of coronary artery disease in a Japanese population."
    J Hum Genet. 2016 61:435-441
  2. Onouchi Y, Fukazawa R, Yamamura K, Suzuki H, Kakimoto N, Suenaga T, Takeuchi T, Hamada H, Honda T, Yasukawa K, Terai M, Ebata R, Higashi K, Saji T, Kemmotsu Y, Takatsuki S, Ouchi K, Kishi F, Yoshikawa T, Nagai T, Hamamoto K, Sato Y, Honda A, Kobayashi H, Sato J, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Yoshiyama M, Miyashita R, Murata Y, Fujino A, Ozaki K, Kawasaki T, Abe J, Seki M, Kobayashi T, Arakawa H, Ogawa S, Hara T, Hata A, Tanaka T.:
    "Variations in ORAI1 Gene Associated with Kawasaki Disease."
    PLoS One. 2016 20;e0145486.
  3. Matsukura M, Ozaki K, Takahashi A, Onouchi Y, Morizono T, Komai H, Shigematsu H, Kudo T, Inoue Y, Kimura H, Hosaka A, Shigematsu K, Miyata T, Watanabe T, Tsunoda T, Kubo M, Tanaka T.:
    "Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population."
    PLoS One. 2015 21;:e0139262.
  4. * Glessner JT, Bick AG, Ito K, Homsy JG, Rodriguez-Murillo L, Fromer M, Mazaika E, Vardarajan B, Italia M, Leipzig J, DePalma SR, Golhar R, Sanders SJ, Yamrom B, Ronemus M, Iossifov I, Willsey AJ, State MW, Kaltman JR, White PS, Shen Y, Warburton D, Brueckner M, Seidman C, Goldmuntz E, Gelb BD, Lifton R, Seidman J, Hakonarson H, Chung WK.:
    "Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data."
    Circ Res. 2014 24;884-896.
  5. * Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA Jr, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, Pollak MR, Wilson JG, Seidman JG, Seidman C.:
    "Increased burden of cardiovascular disease in carriers of APOL1 genetic variants."
    Circ Res. 2014 28;845-850.
  6. Onouchi, Y., Ozaki, K., Burns, JC., Shimizu, C., Terai, M., Hamada, H., Honda, T., Suzuki, H., Suenaga, T., Takeuchi, T., Yoshikawa, N., Suzuki, Y., Yasukawa, K., Ebata, R., Higashi, K., Saji, T., Kemmotsu, Y., Takatsuki, S., Ouchi, K., Kishi, F., Yoshikawa, T., Nagai, T., Hamamoto, K., Sato, Y., Honda, A., Kobayashi, H., Sato, J., Shibuta, S., Miyawaki, M., Oishi, K., Yamaga, H., Aoyagi, N., Iwahashi, S., Miyashita, R., Murata, Y., Sasago, K., Takahashi, A., Kamatani, N., Kubo, M., Tsunoda, T., Hata, A., Nakamura, Y., Tanaka, T., Japan Kawasaki Disease Genome Consortium., Abe, J., Kobayashi, T., Arakawa, H., Ichida, F., Nomura, Y., Miura, M., Ikeda, K., Hara, T., Fukazawa, R., Ogawa, S., Hamaoka, K., US Kawasaki Disease Genetics Consortium., Newburger, JW., Baker, AL., Rowley, AH., Shulman, ST., Melish, ME., Mason, WH., Takahashi, M. & Tremoulet, AH.:
    "A genome-wide association study identifies three new risk loci for Kawasaki disease."
    Nature Genetics 44, 517-521 (2012).
  7. Onouchi, Y., Ozaki, K., Buns, JC., Shimizu, C., Hamada, H., Honda, T., Terai, M., Honda, A., Takeuchi, T., Shibuta, S., Suenaga, T., Suzuki, H., Higashi, K., Yasukawa, K., Suzuki, Y., Sasago, K., Kemmotsu, Y., Takatsuki, S., Saji, T., Yoshikawa, T., Nagai, T., Hamamoto, K., Kishi, F., Ouchi, K., Sato, Y., Newburger, JW., Baker, AL., Shulman, ST., Rowley, AH., Yashiro, M., Nakamura, Y., Wakui, K., Fukushima, Y., Fujino, A., Tsunoda, T., Kawasaki, T., Hata, A., Nakamura, Y. & Tanaka, T.:
    "Common variants in CASP3 confer susceptibility to Kawasaki disease."
    Human Molecular Genetics 19, 2898-2906 (2010).
  8. Ozaki, K., Sato, H., Inoue, K., Tsunoda, T., Sakata, Y., Mizuno, H., Lin, T-H., Miyamoto, Y., Aoki, A., Onouchi, Y., Sheu, S-H., Ikegawa, S., Odashiro, K., Nobuyoshi, M., Juo, S-H H., Hori, M., Nakamura, Y. & Tanaka, T.:
    "SNPs in BRAP associated with risk of myocardial infarction in Asian populations."
    Nature Genetics, 41, 329-333 (2009)
  9. Ozaki, K., Inoue, K., Sato, H., Iida, A., Ohnishi, Y., Sekine, A., Sato, H., Odashiro, K., Nobuyoshi, M., Hori, M., Nakamura, Y. & Tanaka, T.:
    "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-a secretion in vitro."
    Nature, 429, 72-75 (2004)
  10. Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T., Sato, H., Sato, H., Hori, M., Nakamura, Y. & Tanaka, T.:
    "Functional SNPs in the lymphotoxin-a gene that are associated with susceptibility to myocardial infarction."
    Nature Genetics, 32, 650-654 (2002)

Lab Members

Principal Investigator

Kaoru Ito
Team Leader

Core Members

Kouichi Ozaki
Senior Research Scientist

Contact information

East Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

Email: kaoru.ito [at] riken.jp

Recent research results