Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Cell Signaling

Group Director: Takashi Saito (Ph.D.)
Takashi  Saito(Ph.D.)

The general goal of this laboratory is to elucidate the mechanism of activation, differentiation and function, and its regulation of T cells which play central roles in the regulation of immune responses and homeostasis. These include the regulation of immunological synapse, T cell receptor-induced signal transduction, co-stimulation regulation and signaling in T cell development. Particularly, the mechanism to induce autoimmune diseases and inflammations caused by aberrant regulation of T cell function and activation will be analyzed to aim to overcome the diseases.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Biology

Research Subjects

  • Mechanism of signal transduction of lymphocyte activation
  • Regulation of T cell activation and tolerance
  • Induction and regulatory mechanism of autoimmune diseases

Selected Publications

  1. Takeuchi, A., Badr, M.E.S.G., Miyauchi, K., Ishihara C., Onishi R., Guo Z., Sasaki, T., Ike H., Takumi, A., Tsuji N.M., Murakami, Y., Katakai, T. and Saito, T.:
    “CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.”
    J. Exp.Med. 213:.123-138 (2016).
  2. Hara, H., Yokosuka, T., Hirakawa, H., Ishihara, C., Yasukawa, S., Yamazaki, M., Koseki, H., Yoshida, H. and Saito, T. :
    “Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-kB signaling.”
    Nat. Commun. 6:5555 (2015).
  3. Imanishi, T., Ishihara C., El Sherif Badr, M., Kimura Y, Kawai, T., Takeuchi, O., Taniguchi, S-I., Noda, T., Hirano, H., Brombacher, F., Barber, G., Akira, S. and Saito, T.:
    “Nucleic acid sensing by T cells initiates Th2 cell differentiation.”
    Nat.Commun.5:3566 (2014).
  4. Tsukumo, S., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K. and Saito, T.:
    “Bach2 maintains T cells in naïve state by suppressing effector memory-related genes.”
    Proc.Natl.Acad.Sci. 110: 10735-10740 (2013).
  5. Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M. and Saito, T.:
    “Programmed cell death-1 forms negative costimulatory microclusters that directly inhibit T cell receptor signals by recruitment of phosphatase SHP2.”
    J. Exp. Med. 209:1201-1217 (2012).
  6. Hashimoto-Tane, A., Yokosuka, T., Sakata-Sogawa, K., Sakuma, M., Ishihara, C., Tokunaga, M. and Saito, T.:
    “Dynein-driven transport of T cell receptor microclusters regulates immune synapse and T cell activation.”
    Immunity 34:919-931 (2011).
  7. Yokosuka T., Kobayashi, W., Takamatsu, Sakata-Sogawa, K., Zang, H., Hashimoto-Tane, A., M., Yagita, H., Tokunaga, M. and Saito, T.:
    “Spatiotemporal basis of CTLA4-mediated negative regulation of T-cell activation.”
    Immunity 33:326-339 (2010).
  8. Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K. and Saito, T.:
    “Mincle is an ITAM-coupled activating receptor that senses damaged cells.”
    Nat. Immunol. 9: 1179-1188 (2008).
  9. Yokosuka, T., Kobayashi, W., Sakata-Sogawa, K., Hashimoto-Tane, A., Dustin, M.L., Tokunaga, M. and Saito, T.:
    “Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation.”
    Immunity. 29: 589-601 (2008).
  10. Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S.W., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H., Penninger, J.M. and Saito, T.:
    “The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.”
    Nat. Immunol. 8: 619-629 (2007).

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7037
Fax: +81-(0)45-503-7036

Email: takashi.saito [at] riken.jp

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