Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Cytokine Regulation

Team Leader: Masato Kubo (Ph.D.)
Masato  Kubo(Ph.D.)

The goals of Laboratory for cytokine regulation are to understand the cytokine network mechanisms that control immune cell homeostasis, particularly focus on allergy and virus infection. In this context, distinct Helper T (TH) subsets, TH1, TH2, TH17, and TFH, secrete different set of cytokines, which play a role in the effector and regulatory functions during pathogenic situation. Innate immune cells, including mast cells, basophiles, and innate lymphoid cells may also contribute to the pathogenesis by their expressing cytokines. We focus on how cytokines influence the balance of helper T cell and the innate responses during immunological surveillance system.

Keywords

  • cytokine
  • T cell biology
  • Humoral immune response
  • Vaccine

Selected Publications

  1. Wang, Y., Kuang, Z., Yu, X., Ruhn, KA, Kubo, M. and Hooper, LV.:
    "The intestinal microbiota regulates body composition through NFIL3 and the circadian clock."
    Science 357, 912–916. (2017)
  2. Miyauchi, K. and Kubo, M.:
    "Is germinal center selection required in influenza vaccination?"
    Cell. Mol. Immunol. 14, 655–657 (2017)
  3. Kubo, M.:
    "Innate and adaptive type 2 immunity in lung allergic inflammation"
    Immunol. Rev. 278(1). 162-172 (2017)
  4. Kubo, M.:
    "T follicular helper and TH2 cells in allergic responses."
    Allergol Int. 66,377-381 (2017)
  5. Domínguez-Hüttinger, E., Christodoulides, P., Miyauchi, K., Irvine, AD., Okada-Hatakeyama, M., Kubo, M. and Tanaka, RJ.:
    "Mathematical modeling of atopic dermatitis reveals “double-switch” mechanisms underlying 4 common disease phenotypes"
    J. Allergy. Clin. Immunol. 139(6):1861-1872(2017)
  6. Miyauchi, K., Sugimoto-Ishige, A., Harada, Y., Adachi, Y., Usami, Y., Kaji, T., Inoue, K., Hasegawa, H., Watanabe, T., Hijikata, A., Fukuyama, S., Maemura, T., Okada-Hatakeyama, M., Ohara, O., Kawaoka, Y., Takahashi, Y., Takemori, T., and Kubo, M.:
    "Protective neutralizing influenza antibody response in the absence of T follicular helper cells"
    Nat. Immunol. 17, p1447-1458(2016)
  7. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, and Yoshida H.:
    "Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis."
    J. Clin. Invest. 126(6):2064–2076(2016)
  8. Kubo, M.:
    "TCF-1 and LEF-1 help launch the T(FH) program"
    Nat. Immunol. 16(9):900-901(2015)
  9. Xu, W. Domingues, RG., Fonseca-Pereira, D., Ferreira, M., Ribeiro, H., Lopez-Lastra, S., Motomura, Y., Moreira-Santos, L., Bihl, F., Braud,V., Kee, B., Brady, H., Coles, MC., Vosshenrich, C., Kubo, M., Di Santo, J.P. and Veiga-Fernandes, H.:
    "NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors."
    Cell Rep. 10(12), 2043–2054(2015)
  10. Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Endo TA, Kuroki, Y., Ohara, O., Koyasu,S. and Kubo, M.:
    "Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation"
    Immunity 40(5) 758–771(2014)

Lab Members

Principal Investigator

Masato Kubo
Team Leader

Core Members

Kosuke Miyauchi
Research Scientist

Contact information

North Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7047
Fax: +81-(0)45-503-7046

Email: masato.kubo [at] riken.jp

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Recent research results

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