Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Endocrinology, Metabolism and Kidney Diseases

Team Leader: Momoko Horikoshi (M.D., Ph.D)

A prevalence of life-style related diseases, such as diabetes mellitus, is progressively increasing worldwide, especially in East Asian countries, including Japan. Diabetic nephropathy is a leading cause of renal death, and more than sixteen thousands of patients are introduced to chronic renal replacement therapy due to diabetic nephropathy every year in Japan. The pathogenesis of these diseases has been thought to be multi-factorial, and genetic susceptibility is considered as an important factor for the development and the progression of diabetes and diabetic nephropathy. Our laboratory aims to accumulate genomic data, which are useful to understanding the pathogenesis, therapeutic effect, and prognosis of endocrine, metabolic and kidney diseases, and to translate the information into clinical practice.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Clinical Medicine

Research Subjects

  • The identification of the gene conferring susceptibility to diabetic nephropathy
  • The identification of the gene conferring susceptibility to type 2 diabetes
  • The identification of the gene conferring susceptibility to kidney diseases

Selected Publications

  1. Hara, K., Fujita, H., Johnson, TA. et al.:
    "Genome-Wide Association Study Identifies Three Novel Loci for Type 2 Diabetes."
    Hum Mol Genet 23: 239−246, 2014
  2. Okada, Y., Sim, X., Go, MJ. et al.:
    "Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations."
    Nat Genet 44, 904-909 2012
  3. Imamura, M., Maeda, S., Yamauchi, T. et al.:
    "A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations."
    Hum Mol Genet 21, 3042-3049 2012
  4. Cho, Y.S., Chen, C-H., Hu, C. et al.:
    "Meta-analysis of genome-wide association studies identifies 8 new loci for type 2 diabetes in East Asians."
    Nat Genet 44, 67-72 2012
  5. Okamoto, K., Tokunaga, K., Doi, K. et al.:
    "Common variation in GPC5 is associated with acquired nephrotic syndrome."
    Nat Genet 43, 459-463 2011
  6. Yamauchi, T., Hara, K., Maeda, S. et al:
    "A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A/B."
    Nat Genet 42, 864-868 2010
  7. Maeda, S., Kobayashi, M., Araki, S. et al.:
    "A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene is Associated with Proteinuria in Patients with Type 2 Diabetes."
    PLoS Genetcs 6, e1000842 2010
  8. Unoki, H., Takahashi, A., Kawaguchi, T.:
    "SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations."
    Nat Genet 40, 1097-1102 2008
  9. Shimazaki, A., Kawamura, Y., Kanazawa, A et al.:
    "Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy."
    Diabetes 54, 1171-1178 2005
  10. Kanazawa, A., Tsukada, S., Sekine, A. et al.:
    "Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes."
    Am J Hum Genet 75, 832-843 2004

Lab Members

Principal Investigator

Momoko Horikoshi
Team Leader

Core Members

Makiko Taira
Postdoctoral Researcher

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

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