Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Gut Homeostasis

Team Leader: Kenya Honda (M.D., Ph.D)
Kenya  Honda(M.D., Ph.D)

The mammalian alimentary tract harbors about a thousand of species of commensal microorganisms that homeostatically interact with the host. Our team is focusing on immunological attributes of the microbiota and trying to identify responsible members of the microbiota and their derived factors that deeply affect the immune system. Our long term goal is to develop a way to manipulate and normalize compositions of the gut microbiota to treat various disease conditions, such as inflammatory bowel disease (IBD) and allergy.

Main Research Field

Immunology

Related Research Fields

Microbiology

Research Subjects

  • Influences of the gut microbiota on the host immune system
  • Identification of previously unidentified gut unique immune cell subsets
  • Development of new therapeutic ways to treat IBD, allergy, and cancer by means of manipulation of the gut microbiota

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H, Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nuñez G, Camp JG, Hattori M, Umesaki Y, Honda K.:
    “Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.”
    Cell 163:367-380. 2015
  2. Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G.:
    “The microbiota regulates type 2 immunity through RORγt⁺ T cells.”
    Science 349:989-993.(2015)
  3. Narushima S, Sugiura Y, Oshima K, Atarashi K, Hattori M, Suematsu M, Honda K. :
    “Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia.”
    Gut Microbes 5:333-339. (2014)
  4. Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K.:
    "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota."
    Nature 500:232-236. (2013)
  5. Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N.:
    "Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome."
    Nature 499:97-101. (2013)
  6. Honda K, Littman DR.:
    "The microbiome in infectious disease and inflammation."
    Annu Rev Immunol. 30:759-95. (2012)
  7. *Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K.:
    "Induction of colonic regulatory T cells by indigenous Clostridium species."
    Science. 331:337-41. (2011)
  8. *Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR.:
    "Induction of intestinal Th17 cells by segmented filamentous bacteria."
    Cell. 139:485-98. (2009)
  9. *Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K.:
    "ATP drives lamina propria TH17 cell differentiation."
    Nature 455:808-12. (2008)
  10. *Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.:
    "IRF-7 is the master regulator of type-I interferon-dependent immune responses."
    Nature 434:772-777. (2005).

Lab Members

Principal Investigator

Kenya Honda
Team Leader

Core Members

Seiko Narushima
Research Scientist
Takeshi Tanoue
Special Postdoctoral Researcher
Takaaki Kawaguchi
Junior Research Associate
Manabu Nagayama
Junior Research Associate
Satoshi Sasajima
Technical Staff II

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9682

Email: kenya.honda [at] riken.jp

Related links

Recent research results

February 19, 2016: RIKEN RESEARCH
Good neighbors make good defenses