Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Gut Homeostasis

Team Leader: Kenya Honda (M.D., Ph.D)
Kenya  Honda(M.D., Ph.D)

The mammalian alimentary tract harbors about a thousand of species of commensal microorganisms that homeostatically interact with the host. Our team is focusing on immunological attributes of the microbiota and trying to identify responsible members of the microbiota and their derived factors that deeply affect the immune system. Our long term goal is to develop a way to manipulate and normalize compositions of the gut microbiota to treat various disease conditions, such as inflammatory bowel disease (IBD), autoimmunity, allergy and cancer.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Biological Sciences / Biology

Keywords

  • Gut microflora
  • Microbiota
  • Mucosal Immunity

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash, M., Pevsner-Fischer, M., Kartvelishvily, E., Brandis, A., Harmelin, A., Shibolet O, Halpern Z, Honda K, Amit I, Segal, E, Elinav E:
    "Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations."
    Cell, 167(6):1495-1510 (2016).
  2. Mathewson ND, Jenq R, Mathew AV, Koenigsknecht M, Hanash A, Toubai T, Oravecz-Wilson K, Wu SR, Sun Y, Rossi C, Fujiwara H, Byun J, Shono Y, Lindemans C, Calafiore M, Schmidt TC, Honda K, Young VB, Pennathur S, van den Brink M, Reddy P:
    "Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease."
    Nat. Immunol. 17(5):505 (2016).
  3. Honda K, Littman DR:
    "The microbiota in adaptive immune homeostasis and disease."
    Nature, 535:75-84 (2016).
  4. Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K:
    "Helminth infection promotes colonization resistance via type 2 immunity."
    Science, 352(6285):608-612 (2016).
  5. Tanoue T, Atarashi K, Honda K:
    "Development and maintenance of intestinal regulatory T cells."
    Nat. Rev. Immunol., 16(5):295-309 (2016).
  6. Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H, Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nuñez G, Camp JG, Hattori M, Umesaki Y, Honda K:
    "Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells."
    Cell, 163:367-380 (2015).
  7. Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K:
    "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota."
    Nature, 500:232-236 (2013).
  8. Honda K, Littman DR:
    "The microbiome in infectious disease and inflammation."
    Annu Rev Immunol., 30:759-95 (2012).
  9. *Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K:
    "Induction of colonic regulatory T cells by indigenous Clostridium species."
    Science, 331:337-41 (2011).
  10. *Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR:
    "Induction of intestinal Th17 cells by segmented filamentous bacteria."
    Cell, 139:485-98 (2009).

Lab Members

Principal Investigator

Kenya Honda
Team Leader

Core Members

Seiko Narushima
Research Scientist
Takeshi Tanoue
Special Postdoctoral Researcher
Takaaki Kawaguchi
Junior Research Associate
Manabu Nagayama
Junior Research Associate
Sayoko Saegusa
Technical Staff II
Satoshi Sasajima
Technical Staff II

Contact information

4F, North Research Building
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9682

Email: kenya.honda [at] riken.jp

Related links

Recent research results

February 19, 2016: RIKEN RESEARCH
Good neighbors make good defenses

Events