Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for International Alliance on Genomic Research

Team Leader: Taisei Mushiroda (Ph.D.)
Taisei  Mushiroda(Ph.D.)

The main aim of our laboratory is, through collaborations in Japan and internationally, to identify useful biomarkers which could be used to predict drug-induced adverse events, guide drug use and be used in disease prediction diagnosis. We actively recruit young scientists from overseas to work at RIKEN and carry out research in SNP-based approach, statistical analysis and biological analysis. Our long-term goal is to establish an international SNP research network that will make the Center for Integrative Medical Sciences a world leader in personalized medicine.

Main Research Field

Medicine, dentistry, and pharmacy

Research Subjects

  • The role of human leukocyte antigen (HLA) in drug-induced adverse drug reactions
  • Phenytoin and co-trimoxazole induced Stevens-Johnson Syndrome and Toxic epidermal necrolysis
  • Identification of genes associated with clopidogrel treatment outcome in Asian populations

Selected Publications

  1. *Chien-Hsiun Chen, Chau-Shoun Lee, Ming-Ta Michael Lee, Wen-Chen Ouyang, Chiao-Chicy Chen, Happy Kuy-Lok Tan, Mian-Yoon Chong, , Liang-Jen Chuo, Nan-Ying Chiu, Hin-Yeung Tsang, Ta-Jen Chang, For-Wey Lung, Chen-Huan Chiu, Cheng-Ho Chang, Ying-Sheue Chen, Yuh-Ming Hou, Te-Jen Lai, Chun-Liang Tung, Chung-Ying Chen, Hsien-Yuan Lane, Jung Feng, Jin-Jia Lin, Ching-Jui Chang, Po-Ren Teng, Chia-Yih Liu, Chih-Ken Chen, I-Chao Liu, Jiahn-Jyh Chen, Chun-Chieh Fan, Chang-Fang Li, Kathy Hsiao-Tsz Wang, Lawrence Shih-Hsin Wu, Hsin-Ling Peng, Jer-Yuarn Wu, Yuan-Tsong Chen, and Andrew Tai-Ann Cheng:
    “Variant GADL1 and Response to Lithium Prophylaxis Treatment in Bipolar I Disorder”
    NEJM 370 (2):119-28 (2014)
  2. Minami Ohara, Harumi Takahashi, M.T. Michael Lee, Mari Shiomi, Kiyoshi Mihara, Ming-Shien Wen, Tsong-Hai Lee, Hui-Ping Chuang, Takashi Morita, Yuan-Tsong Chen.:
    “Determinants of the Over-Anticoagulation Response during Warfarin Initiation Therapy in Asian Patients based on Population Pharmacokinetic-Pharmacodynamic Analyses”
    PLoS One 9, e105891, 2014
  3. Kelly E. Caudle, Allan E. Rettie, Michelle Whirl-Carrillo, Lisa H. Smith, Scott E. Mintzer, Ming Ta Michael Lee, Teri E. Klein, J. Thomas Callaghan:
    “Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B genotype and Phenytoin Dosing”
    Clinical Pharmacology and Therapeutics 96(5):542-8, 2014
  4. Ming Ta Michel Lee*, Surakameth Mahasirimongkol, Yanfei Zhang, Wimon Suwankesawong, Usa Chaikledkaew, Cristiana Pavlidis, George P. Patrinos, Wasun Chantratita.
    Clinical application of pharmacogenomics: The example of HLA-based drug-induced toxicity
    Public Health Genomics 2014;17(5-6):248-55
  5. David N. Cooper, Angela Brand, Vita Dolzan, Paolo Fortina, Federico Innocenti, Ming Ta Michael Lee, Milan Macek Jr, Fahd Al-Mulla, Barbara Prainsack, Alessio Squassina, Effy Vayena, Athanassios Vozikis, Marc Williams, George P. Patrinos:
    “Bridging genomics research between developed and developing countries: The Genomic Medicine Alliance”
    Personalized Medicine. 11(7), 615–623, 2014
  6. Michael S. Hershfield, John T. Callaghan, Wichittra Tassaneeyakul, Taisei Mushiroda, Caroline F.Thorn, Teri E. Klein and Ming Ta Michael Lee:
    “Clinical Pharmacogenetics Implementation Consortium Guidelines for Human leukocyte antigen B (HLA-B) Genotype and Allopurinol Dosing”
    Clinical Pharmacology and Therapeutics. 93 (2): 153-158, 2013
  7. *Yanbing Zu, Min-Han Tan, Balram Chowbay, Soo Chin Lee, Huiling Yap, Ming Ta Michael Lee, Liang-Suei Lu, Chun-Ping Chang, and Jackie Y. Ying:
    “Nanoprobe-based Genetic Testing”
    Nano Today 9 (2): 166–171, 2014
  8. *Josè Antonio Cornejo-García, Lieh-Bang Liou, Natalia Blanca-López, Inmaculada Doña, Chien-Hsiun Chen, Hui-Ping Chuang, Jer-Yuarn Wu, Yuan-Tsong Chen, María del Carmen Plaza-Serón, Cristobalina Mayorga, Rosa Maríía Guéant-Rodríguez, Shih-Chang Lin, María José Torres, Paloma Campo, Carmen Rondón, José Julio Laguna, Javier Fernández, Jean-Louis Guéant, Gabriela Canto, Miguel Blanca, Ming Ta Michael Lee:
    “GENOME-WIDE ASSOCIATION STUDY IN NSAIDs-INDUCED ACUTE URTICARIA/ANGIOEDEMA IN SPANISH AND HAN-CHINESE POPULATIONS”
    Pharmacogenomics 14(15), 1857-1869, 2013
  9. Yasuko Okano, Uru Nezu, Yasuaki Enokida, Ming Ta Michael Lee, Hiroko Kinoshita, Alexander Lezhava, Yoshihide Hayashizaki, Satoshi Morita, Masataka Taguri, Yasushi Ichikawa, Takeshi Kaneko, Yutaka Natsumeda, Tomoyuki Yokose, Haruhiko Nakayama, Yohei Miyagi, and Toshihisa Ishikawa:
    “A new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women”
    PLoS One. 8(9): e73794

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9589
Fax: +81-(0)45-503-9566

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