Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Intestinal Ecosystem

Group Director: Hiroshi Ohno (M.D., Ph.D)
Hiroshi  Ohno(M.D., Ph.D)

This group is interested in the intestinal immune system, especially the molecular mechanisms of the function and differentiation of M cells, a subset of intestinal epithelium specialized for uptake of particulate antigens such as bacteria and viruses. We are also studying the role of host-gut microbiota interaction on the host physiology and pathology.

Main Research Field


Related Research Fields

Biology & Biochemistry / Molecular Biology & Genetics / Microbiology

Research Subjects

  • The role of M cells in the intestinal immune system
  • Elucidation of the mechanisms for M-cell differentiation
  • The role of gut microbiota on host physiology and pathology

Selected Publications

  1. Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M., Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K., and Ohno, H.:
    "Commensal microbe-derived butyrate induces colonic regulatory T cells"
    Nature 504, 446-450 (2013)
  2. Hase, K., Nakatsu, F., Ohmae, M., Sugihara, K., Shioda, N., Takahashi, D., Obata, Y., Furusawa, Y., Fujimura, Y., Yamashita, T., Fukuda, S., Okamoto, H., Asano, M., Yonemura, S., and Ohno, H.:
    "AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice"
    Gastroenterol. 145, 625-635 (2013)
  3. Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., McSorley, S. J., Kaisho, T., Williams, I. R., and Ohno, H.:
    "The Ets transcription factor Spi-B is essential for the differentiation of intestinal M cells"
    Nat. Immunol., 13, 729-736 (2012)
  4. Takahashi, D., Hase, K., Kimura, S., Nakatsu, F., Ohmae, M., Mandai, Y., Sato, T., Date, Y., Ebisawa, M., Kato, T., Obata, Y., Fukuda, S., Kawamura, Y., Dohi, T., Katsuno, T., Yokosuka, O., Waguri, S., and Ohno, H.:
    "The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice"
    Gatroenterol. 141, 621-632 (2011)
  5. Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., and Ohno, H.:
    "Bifidobacteria can protect from enteropathogenic infection through production of acetate"
    Nature, 469, 543-547 (2011)
  6. Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelet, C. C., Yeaman, C., and Ohno, H.:
    "M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex"
    Nature Cell Biol. 11, 1427-1432 (2009)
  7. Hase, K., Kawano, K., Nochi, T., Pontes, G. S., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S. I., Lowe, A. W., Waguri, S., Itoh, K, Kiyono, H., and Ohno, H.:
    "Uptake through Glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response"
    Nature 462, 226-230 (2009)

Lab Members

Principal Investigator

Hiroshi Ohno
Group Director

Core Members

Yumiko Nakanishi
Research Scientist
Takashi Kanaya
Research Scientist
Zijin Guo
Research Scientist
Naoko Satoh
Research Scientist
Eiji Miyauchi
Special Postdoctoral Researcher
Kendle Maslowski
Foreign Postdoctoral Researcher
Tamotsu Kato
Postdoctoral Researcher
Takaharu Sasaki
Postdoctoral Researcher
Tadashi Takeuchi
Junior Research Associate
Naoko Atarashi
Technical Staff I
Tomoko Kageyama
Technical Staff II
Masumi Takahashi
Technical Staff II
Masami Aoki
Technical Staff II
Ayumi Ito
Technical Staff II
Sayuri Sakakibara
Technical Staff II
Kumiko Nakai
Technical Staff II
Naoko Tachibana
Technical Staff II

Contact information

C619 Central Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

Email: hiroshi.ohno [at]

Related links

Recent research results

August 10, 2017: RIKEN RESEARCH
The mast-er of worm defense