Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Intestinal Ecosystem

Team Leader: Hiroshi Ohno (M.D., Ph.D)
Hiroshi  Ohno(M.D., Ph.D)

This group is interested in the intestinal immune system, especially the molecular mechanisms of the function and differentiation of M cells, a subset of intestinal epithelium specialized for uptake of particulate antigens such as bacteria and viruses. We are also studying the role of host-gut microbiota interaction on the host physiology and pathology.

Main Research Field

Immunology

Related Research Fields

Biology & Biochemistry / Molecular Biology & Genetics / Microbiology

Keywords

  • Intestinal epithelial cells
  • M cell
  • Host-gut microbiota interaction
  • Intestinal immune system

Selected Publications

  1. Shimokawa, C., Kanaya, T., Hachisuka, M., Ishiwata, K., Hisaeda, H., Kurashima, Y., Kiyono, H., Yoshimoto, T., Kaisho, T., Ohno, H.:
    "Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections."
    Immunity 46: 863-874, 2017
  2. Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shiba.ta, N, Williams, I. R., Kiyono, H., Ohno, H.:
    "IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake."
    J. Exp. Med. 163(2): 367-380, 2017
  3. Hashimoto, M., Bhuyan, F., Hiyoshi, M., Noyori, O, Nasseer, H., Miyazaki, M., Saito, T., Kondo, Y., Osada, H., Kimura, S., Hase, K., Ohno, H., Suzu, S.:
    "Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages."
    J. Immunol. 196(4): 1832-1841, 2016
  4. Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M., Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K., and Ohno, H.:
    "Commensal microbe-derived butyrate induces colonic regulatory T cells"
    Nature 504, 446-450 (2013)
  5. Hase, K., Nakatsu, F., Ohmae, M., Sugihara, K., Shioda, N., Takahashi, D., Obata, Y., Furusawa, Y., Fujimura, Y., Yamashita, T., Fukuda, S., Okamoto, H., Asano, M., Yonemura, S., and Ohno, H.:
    "AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice"
    Gastroenterol. 145, 625-635 (2013)
  6. Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., McSorley, S. J., Kaisho, T., Williams, I. R., and Ohno, H.:
    "The Ets transcription factor Spi-B is essential for the differentiation of intestinal M cells"
    Nat. Immunol., 13, 729-736 (2012)
  7. Takahashi, D., Hase, K., Kimura, S., Nakatsu, F., Ohmae, M., Mandai, Y., Sato, T., Date, Y., Ebisawa, M., Kato, T., Obata, Y., Fukuda, S., Kawamura, Y., Dohi, T., Katsuno, T., Yokosuka, O., Waguri, S., and Ohno, H.:
    "The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice"
    Gatroenterol. 141, 621-632 (2011)
  8. Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., and Ohno, H.:
    "Bifidobacteria can protect from enteropathogenic infection through production of acetate"
    Nature, 469, 543-547 (2011)
  9. Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelet, C. C., Yeaman, C., and Ohno, H.:
    "M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex"
    Nature Cell Biol. 11, 1427-1432 (2009)
  10. Hase, K., Kawano, K., Nochi, T., Pontes, G. S., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S. I., Lowe, A. W., Waguri, S., Itoh, K, Kiyono, H., and Ohno, H.:
    "Uptake through Glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response"
    Nature 462, 226-230 (2009)

Lab Members

Principal Investigator

Hiroshi Ohno
Team Leader

Core Members

Yumiko Nakanishi
Research Scientist
Takashi Kanaya
Research Scientist
Zijin Guo
Research Scientist
Naoko Satoh
Research Scientist
Eiji Miyauchi
Special Postdoctoral Researcher
Kendle Maslowski
Foreign Postdoctoral Researcher
Tamotsu Kato
Postdoctoral Researcher
Takaharu Sasaki
Postdoctoral Researcher
Tadashi Takeuchi
Junior Research Associate
Naoko Atarashi
Technical Staff I
Tomoko Kageyama
Technical Staff II
Masumi Takahashi
Technical Staff II
Masami Aoki
Technical Staff II
Ayumi Ito
Technical Staff II
Sayuri Sakakibara
Technical Staff II
Kumiko Nakai
Technical Staff II
Naoko Tachibana
Technical Staff II

Contact information

N309Aa North Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7031

Email: hiroshi.ohno [at] riken.jp

Related links

Recent research results

August 10, 2017: RIKEN RESEARCH
The mast-er of worm defense