Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Lymphocyte Differentiation

Team Leader: Tomohiro Kurosaki (M.D., Ph.D)
Tomohiro  Kurosaki(M.D., Ph.D)

Memory humoral responses are typically more rapid, have a greater magnitude, and consist of antibodies of higher affinity than in the primary response. Our laboratory has now focused on clarifying the functional characterization of memory B cells and memory T cells and on revealing the mechanisms underlying the robustness of memory antibody responses.

Main Research Field

Biology

Related Research Fields

Medicine, dentistry, and pharmacy

Keywords

  • Immunological tolerance, autoimmunity
  • Lymphocyte
  • Immunological memory
  • Antibody

Selected Publications

  1. Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T.:
    "The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help"
    J Exp Med (in press, 2017)
  2. Igarashi K, Kurosaki T, Roychoudhuri R.:
    "BACH transcription factors in innate and adaptive immunity"
    Nat Rev Immunol 17, 437-450 (2017)
  3. Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki, T.:
    "Regulated selection of germinal center cells into the memory B cell compartment"
    Nat Immunol 17, 861-869 (2016)
  4. Inoue, T., Morita, M., Hijikata, A., Fukuda-Yuzawa, Y., Adachi, S., Isono, K., Ikawa, T., Kawamoto, H., Koseki, H., Natsume, T., Fukao, T., Ohara, O., Yamamoto, T., Kurosaki, T.:
    "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability"
    J Exp Med 212, 1465-1479 (2015)
  5. Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, Sewon, Akira, S., Sako, Y., *Hoffmann, A., *Kurosaki, T., *Okada-Hatakeyama, M.:
    "Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation. (*co-corresponding authors)"
    Science 344, 760-764 (2014)
  6. Ise, W., Inoue, T., McLachlan, J.B., Kometani, K., Kubo, M., Okada, T. Kurosaki, T.:
    "Memory B cells contribute to rapid Bcl6 expression by memory TFH cells"
    Proc. Natl. Acad. U.S.A. 111, 11792-11797 (2014)
  7. Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S.L., Sakaguchi, S., Takeda, K., Kurosaki, T., Baba, Y.:
    "Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation"
    Immunity 41, 1040-1051 (2014)
  8. Kometani, K., Nakagawa, R., Shinnakasu, R., Kaji, T., Rybouchkin, A., Moriyama, S., Furukawa, K., Koseki, H., Takemori, T. and Kurosaki, T.:
    "Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation"
    Immunity 39, 136-147 (2013)
  9. Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and Iwai, K.:
    "Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells"
    EMBO J 32, 2463-2476 (2013)
  10. Capietto, A.H., Kim, S., Sanford, D.E., Liehan, D.C., Hikida, M., Kurosaki, T., Novack, D.V. and Faccio, R.:
    "Downregulation of PLCγ2/β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer"
    J. Exp. Med. 210, 2257-2271 (2013)

Lab Members

Principal Investigator

Tomohiro Kurosaki
Team Leader

Core Members

Hidehiro Fukuyama
Senior Research Scientist
Chieko Okamura
Technical Staff I

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7019

Email: tomohiro.kurosaki [at] riken.jp

Related links

Recent research results