Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Lymphocyte Differentiation

Group Director: Tomohiro Kurosaki (M.D., Ph.D)
Tomohiro  Kurosaki(M.D., Ph.D)

Memory humoral responses are typically more rapid, have a greater magnitude, and consist of antibodies of higher affinity than in the primary response. Our laboratory has now focused on clarifying the functional characterization of memory B cells and memory T cells and on revealing the mechanisms underlying the robustness of memory antibody responses.

Main Research Field

Biology

Related Research Fields

Medicine, dentistry, and pharmacy

Research Subjects

  • Characterization of memory TFH cells
  • Regulation of Bach2 during immune responses
  • Development of a next-generation vaccine for influenza virus

Selected Publications

  1. Baba, Y., Matsumoto, M., Kurosaki, T.:
    "Calcium signaling in B cells: Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2."
    Mol. Immunol. (2013) e-pub ahead of print
  2. Kometani, K., Nakagawa, R., Shinnakasu, R., Kaji, T., Rybouchkin, A., Moriyama, S., Furukawa, K., Koseki, H., Takemori, T. and Kurosaki, T.:
    "Repression of Bach2 predisposes IgG1 memory B cells toward plasma cell differentiation"
    Immunity 39, 136-147 (2013)
  3. Onodera, T., Takahashi, Y., Yokoi, Y., Ato, M., Kodama, Y., Hachiman, S., Kurosaki, T. and Kobayashi, K.:
    "Memory B cells in the lung participate in protective humoral immune responses against recurrent pulmonary influenza virus infection"
    Proc. Natl. Acad. Sci. U.S.A. 109, 2485-90 (2012).
  4. Kitano, M., Moriyama, S., Ando, Y., Hikida, M., Mori, Y., Matsuda, M., Kurosaki, T. and Okada, T.:
    "BCL6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity"
    Immunity 34, 961-972 (2011).
  5. Kometani, K., Yamada, T., Sasaki, Y., Yokosuka, T., Saito, T., Rajewsky, K., Ishiai, M., Hikida, M. and Kurosaki, T.:
    "CIN85 drives B cell responses by linking BCR signals to the canonical NF- B pathway"
    J. Exp. Med. 208, 1447-1457 (2011).
  6. Matsumoto, M., Fujii, Y., Baba, A., Hikida, M., Kurosaki, T. and Baba, Y.:
    "The calcium sensors STIM1 and STIM2 control B cell regulatory function through IL-10 production"
    Immunity. 34, 703-714 (2011).
  7. Yasuda T., Kometani, K., Takahashi, N., Imai, Y., Aiba, Y. and Kurosaki, T.:
    "Erk kinases control plasma cell differentiation by regulating expression of Blimp-1"
    Sci. Signal. 4, (169) ra25 (2011).
  8. Kurosaki, T., Aiba, Y., Kometani, K., Moriyama, S. and Takahashi, Y.:
    "Unique properties of memory B cells of different isotypes"
    Immunol. Rev. 237, 104-116 (2010).
  9. Aiba, Y., Kometani, K, Hamadate M., Moriyama, S., Sakaue-Sawano, A., Tomura, M., Luche H., Fehling, H.J., Casellas, R., Kanagawa, O., Miyawaki, A. and Kurosaki, T.:
    "Preferential localization of IgG memory B cells adjacent to contarcted germinal centers"
    Proc. Natl. Acad. Sci. U.S.A. 107, 12192-12197 (2010).
  10. Kurosaki, T., Shinohara, H. and Baba, Y.:
    "B cell signaling and fate decision"
    Ann. Rev. Immunol. 28, 21-55 (2010).

Lab Members

Principal Investigator

Tomohiro Kurosaki
Group Director

Core Members

Hidehiro Fukuyama
Senior Research Scientist
Chieko Okamura
Technical Staff I

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7019

Email: tomohiro.kurosaki [at] riken.jp

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