Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Metabolic Homeostasis

Team Leader: Naoto Kubota (M.D., Ph.D)
Naoto  Kubota(M.D., Ph.D)

Type 2 diabetes is a chronic metabolic disorder characterized by hyperglycemia with impaired insulin secretion and insulin resistance. Progression to type 2 diabetes is influenced by genetic and environmental or acquired factors, such as a sedentary lifestyle and dietary habits that promote obesity associating with insulin resistance. This laboratory undertakes research to elucidate the mechanisms involved in development of obesity, insulin resistance, type 2 diabetes and progression of metabolic syndrome, atherosclerosis at the molecular level, and develops innovative diagnosis and treatment methods based on the above findings, which can be applied to the clinical field.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Biology

Keywords

  • Obesity
  • insulin resistance

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Sasaki M, Sasako T, Kubota N, Sakurai Y, Takamoto I, Kubota T, Inagi R, Seki G, Goto M, Ueki K, Nangaku M, Jomori T, Kadowaki T.:
    "Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney. "
    Diabetes. (2017).
  2. Kubota T, Kubota N, Kadowaki T.:
    "Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway."
    Cell Metab 25, 797-810 (2017)
  3. Hashimoto, S., Kubota, N., Sato, H., Sasaki, M., Takamoto, I., Kubota, T., Nakaya, K., Noda, M., Ueki, K., Kadowaki, T.:
    "Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion."
    Diabetes 64, 876-86 (2015).
  4. Takamoto, I., Kubota, N., Nakaya, K., Kumagai, K., Hashimoto, S., Kubota, T., Inoue, M., Kajiwara, E., Katsuyama, H., Obata, A., Sakurai, Y., Iwamoto, M., Kitamura, T., Ueki, K., and Kadowaki, T.:
    "TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass."
    Diabetologia 57, 542-553 (2014).
  5. *Kadowaki, T., Ueki, K., Yamauchi, T., and Kubota, N.:
    "SnapShot: Insulin signaling pathways."
    Cell 148, 624, 624.e1 (2012).
  6. *Kubota T*., Kubota N*#., Kumagai H*., Yamaguchi S., Kozono H., Takahashi T., Inoue M., Itoh S., Takamoto I., Sasako T., Kumagai K., Kawai T., Hashimoto S., Kobayashi T., Sato M., Tokuyama K., Nishimura S., Tsunoda M., Ide T., Murakami K., Yamazaki T., Ezaki O., Kawamura K., Masuda H., Moroi M., Sugi K., Oike Y., Shimokawa H., Yanagihara N., Tsutsui M., Terauchi Y., Tobe K., Nagai R., Kamata K., Inoue K., Kodama T., Ueki K., and Kadowaki T.:
    "Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle. (*co-first authors, #co- corresponding authors)."
    Cell Metabolism 13, 294-307 (2011).
  7. *Kubota N., Kubota T., Itoh S., Kumagai H., Kozono H., Takamoto I., Mineyama T., Ogata H., Tokuyama K., Ohsugi M., Sasako T., Moroi M., Sugi K., Kakuta S., Iwakura Y., Noda T., Ohnishi S., Nagai R., Tobe K., Terauchi Y., Ueki K., and Kadowaki T.:
    "Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding."
    Cell Metabolism 8, 49-64 (2008).
  8. *Kubota N., Yano W., Kubota T., Yamauchi T., Itoh S., Kumagai H., Kozono H., Takamoto I., Okamoto S., Shiuchi T., Suzuki R., Satoh H., Tsuchida A., Moroi M., Sugi K., Noda T., Ebinuma H., Ueta Y., Kondo T., Araki E., Ezaki O., Nagai R., Tobe K., Terauchi Y., Ueki K., Minokoshi Y., and Kadowaki T.:
    "Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake."
    Cell Metabolism 6, 55-68 (2007).
  9. *Kubota N., Terauchi Y., Tobe K., Yano W., Suzuki R., Ueki K., Takamoto I., Satoh H., Maki T., Kubota T., Moroi M., Okada-Iwabu M., Ezaki O., Nagai R., Ueta Y., Kadowaki T., and Noda T.:
    "Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus."
    J. Clin. Invest. 114, 917-927 (2004).
  10. *Kubota N., Tobe K., Terauchi Y., Eto K., Yamauchi T., Suzuki R., Tsubamoto Y., Komeda K., Nakano R., Miki H., Satoh S., Sekihara H., Sciacchitano S., Lesniak M., Aizawa S., Nagai R., Kimura S., Akanuma Y., Taylor SI., and Kadowaki T.:
    "Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia."
    Diabetes 49, 1880-1889 (2000).

Lab Members

Principal Investigator

Naoto Kubota
Team Leader

Core Members

Tetsuya Kubota
Senior Research Scientist
Miki Igarashi
Research Scientist

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9111 (Ext: #6483)

Email: naoto.kubota [at] riken.jp

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