Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Respiratory and Allergic Diseases

Team Leader: Mayumi Tamari (M.D., Ph.D)
Mayumi  Tamari(M.D., Ph.D)

We try to clarify the genetic components implicated in the etiology of asthma, chronic rhinosinusitis, allergic rhinitis, atopic dermatitis, food allergy and COPD by genome-wide association studies (GWASs) and molecular biological analysis. We found a total of five susceptibility loci of adult asthma and identified eight new susceptibility loci of atopic dermatitis by GWASs. These findings suggest important roles for epidermal barrier functions, innate-adaptive immunity, regulatory T cells and the vitamin D pathway in the pathogenesis of allergic diseases. We participate in the global consortium for meta-analysis of GWASs of allergic diseases. We will conduct further cross-disciplinary studies combining genetics, immunology and clinical epidemiology for translation of research into clinical practice.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Immunology / Clinical Medicine

Research Subjects

  • Genetics of allergic diseases
  • Genetics of respiratory diseases

Selected Publications

  1. Park, H.W., Dahlin, A., Tse, S., Duan, Q.L., Schuemann, B., Martinez, F.D., Peters, S.P., Szefler, S.J., Lima, J.J., Kubo, M., Tamari, M., and Tantisira, K.G.:
    "Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids"
    J Allergy Clin Immunol 133, 664-669 (2014).
  2. Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M., Takahashi, A., Nakamura, Y., Tsoi, L.C., Stuart, P., Elder, J.T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M.M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B.O., Duerr, R.H., Büning, C., Brand, S., Glas, J., McAleer, M.A., Fahy, C.M., Kabesch, M., Brown, S., McLean, W.H., Irvine, A.D., Schreiber, S., Lee, Y.A., Franke, A., and Weidinger, S.:
    "High-density genotyping study identifies four new susceptibility loci for atopic dermatitis"
    Nat Genet 45, 808-812 (2013).
  3. Tomita, K., Sakashita, M., Hirota, T., Tanaka, S., Masuyama, K., Yamada, T., Fujieda, S., Miyatake, A., Hizawa, N., Kubo, M., Nakamura, Y., and Tamari, M.:
    "Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population"
    Allergy 68, 92-100 (2013).
  4. Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Sakashita, M., Yamada, T., Fujieda, S., Tanaka, S., Doi, S., Miyatake, A., Enomoto, T., Nishiyama, C., Nakano, N., Maeda, K., Okumura, K., Ogawa, H., Ikeda, S., Noguchi, E., Sakamoto, T., Hizawa, N., Ebe, K., Saeki, H., Sasaki, T., Ebihara, T., Amagai, M., Takeuchi, S., Furue, M., Nakamura, Y., and Tamari, M.:
    "Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population"
    Nat Genet 44, 1222-1226 (2012).
  5. Tantisira, K.G., Lasky-Su, J., Harada, M., Murphy, A., Litonjua, A.A., Himes, B.E., Lange, C., Lazarus, R., Sylvia, J., Klanderman, B., Duan, Q.L., Qiu, W., Hirota, T., Martinez, F.D., Mauger, D., Sorkness, C., Szefler, S., Lazarus, S.C., Lemanske, R.F. Jr, Peters, S.P., Lima, J.J., Nakamura, Y., Tamari, M., and Weiss, S.T.:
    "Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma"
    N Engl J Med 365, 1173-1183 (2011).
  6. Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Doi, S., Fujita, K., Miyatake, A., Enomoto, T., Miyagawa, T., Adachi, M., Tanaka, H., Niimi, A., Matsumoto, H., Ito, I., Masuko, H., Sakamoto, T., Hizawa, N., Taniguchi, M., Lima, J.J., Irvin, C.G., Peters, S.P., Himes, B.E., Litonjua, A.A., Tantisira, K.G., Weiss, S.T., Kamatani, N., Nakamura, Y., and Tamari, M.:
    "Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population"
    Nat Genet 43, 893-896 (2011).
  7. Harada, M., Hirota, T., Jodo, A.I., Hitomi, Y., Sakashita, M., Tsunoda, T., Miyagawa, T., Doi, S., Kameda, M., Fujita, K., Miyatake, A., Enomoto, T., Noguchi, E., Masuko, H., Sakamoto, T., Hizawa, N., Suzuki, Y., Yoshihara, S., Adachi, M., Ebisawa, M., Saito, H., Matsumoto, K., Nakajima, T., Mathias, R.A., Rafaels, N., Barnes, K.C., Himes, B.E., Duan, Q.L., Tantisira, K.G., Weiss, S.T., Nakamura, Y., Ziegler, S.F., and Tamari, M.:
    "Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma"
    Am J Respir Cell Mol Biol 44, 787-793 (2011).
  8. Hitomi, Y., Ebisawa, M., Tomikawa, M., Imai, T., Komata, T., Hirota, T., Harada, M., Sakashita, M., Suzuki, Y., Shimojo, N., Kohno, Y., Fujita, K., Miyatake, A., Doi, S., Enomoto, T., Taniguchi, M., Higashi, N., Nakamura, Y., and Tamari, M.:
    "Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma"
    J Allergy Clin Immunol 124, 779-785 (2009).
  9. Harada, M., Obara, K., Hirota, T., Yoshimoto, T., Hitomi, Y., Sakashita, M., Doi, S., Miyatake, A., Fujita, K., Enomoto, T., Taniguchi, M., Higashi, N., Fukutomi, Y., Nakanishi, K., Nakamura, Y., and Tamari, M.:
    "A functional polymorphism in IL-18 is associated with severity of bronchial asthma"
    Am J Respir Crit Care Med 180, 1048-1055 (2009).
  10. Hirota, T., Harada,M., Sakashita, M., Doi, S., Miyatake, A., Fujita, K., Enomoto, T., Ebisawa, M., Yoshihara, S., Noguchi, E., Saito, H., Nakamura, Y., and Tamari M.:
    "Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population"
    J Allergy Clin Immunol 121, 769-770 (2008).

Lab Members

Principal Investigator

Mayumi Tamari
Team Leader

Core Members

Tomomitsu Hirota
Research Scientist

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9616
Fax: +81-(0)45-503-9615

Email: mayumi.tamari [at] riken.jp

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