Centers & Labs

Medical Sciences Innovation Hub Program

Disease Biology Group

Group Director: Haruhiko Koseki (M.D., Ph.D.)
Haruhiko  Koseki(M.D., Ph.D.)

Our aim is to stratify patients' pathophysiology of atopic dermatitis, rheumatoid arthritis, obesity related diseases, based on clinical multimodal data, and to develop optimal methods for preventing onset or exacerbation for each individual, for further utilization in clinical practice. At the same time, we apply the acquired knowledges from human studies to animal models, in order to understand the significance of disease-related factors and to elucidate complex disease pathologies. Our goal is to realize personalized predictive medicine; to measure and predict individual disease state changes through sequential collection and integrative analysis of human clinical data and seamless fusion analysis with animal models.

Main Research Field

Biology

Related Research Fields

Biological Sciences / Medicine, dentistry, and pharmacy

Biology / Basic medicine / Clinical medicine

Keywords

  • Biology
  • Disease model
  • Bioinformatics

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Takahashi S, Ishida A, Kubo A, Kawasaki H, Ochiai S, Nakayama M, Koseki H, Amagai M, Okada T.:
    "Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development."
    Sci Rep. 2019 Jun 13;9(1):8625. doi: 10.1038/s41598-019-44866-0.
  2. Usui K, Kadono N, Furuichi Y, Shiraga K, Saitou T, Kawasaki H, Toyooka K, Tamura H, Kubo A, Amagai M, Matsui T.:
    "3D in vivo imaging of the keratin filament network in the mouse stratum granulosum reveals profilaggrin-dependent regulation of keratin bundling."
    J Dermatol Sci. 2019 Apr 30. pii: S0923-1811(19)30099-4. doi: 10.1016/j.jdermsci.2019.04.006. [Epub ahead of print]
  3. Miyai T, Takano J,, Endo TA, Kawakami E, Agata Y, Motomura Y, Kubo M, Kashima Y, Suzuki Y, Kawamoto H, Ikawa T.:
    "Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells."
    Genes Dev. 15;32(2):112-126. (2018)
  4. Miyamoto A, Lee S, Cooray NF, Lee S, Mori M, Matsuhisa N, Jin H, Yoda L, Yokota T, Itoh A, Sekino M, Kawasaki H, Ebihara T, Amagai M, Someya T.:
    "Inflammation-free, gas-permeable, lightweight, stretchable on-skin electronics with nanomeshes."
    Nat nanotechnol. 12(9):907-913, 2017
  5. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H.:
    "Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis."
    J Clin Invest. 2016 Jun 1;126(6):2064-76. doi: 10.1172/JCI82887. Epub 2016 Apr 25.
  6. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H.:
    "Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis."
    J Clin Invest. 2016 Jun 1;126(6):2064-76. doi: 10.1172/JCI82887. Epub 2016 Apr 25.
  7. *Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, Kong HH, Amagai M, Nagao K.:
    "Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis."
    Immunity 42 (4):756-766, 2015.
  8. *Yokouchi M, Kubo A, Kawasaki H, Yoshida K, Ishii K, Furuse M, Amagai M.:
    "Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum."
    J Dermatol Sci 77 (1):28-36, 2015.

Lab Members

Principal Investigator

Haruhiko Koseki
Group Director

Core Members

Hiroshi Kawasaki
Senior Scientist
Aiko Sekita
Postdoctoral Researcher
Tomohiro Miyai
Postdoctoral Researcher
Rumi Sato
Technical Staff I
Mika Yaguchi
Technical Staff I
Yoko Koseki
Technical Staff II
Ayano Fukushima
Research Part-time Worker I

Contact Information

North building N604Ca
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9691
Fax: +81-(0)45-503-9278

Email: haruhiko.koseki [at] riken.jp