We study deep learning on health and medical data. Each variable in health and medical data has different characteristic, thus data standardization plays critical role for accuracy and efficiency of deep learning. We investigate data generation, data privacy protection, data standardization, deep learning, and data visualization, to achieve personalized preventive medicine based on precise predictions.

Main Research Field

Complex systems

Related Research Fields

Informatics / Biological Sciences / Biology / Medicine, dentistry, and pharmacy

Keywords

• Deep learning
• Systems biology
• Systems medicine

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. *Seita J^*, Beerman I^*, Inlay M, Weissman IL, Rossi DJ.:
   “Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.”
   Cell Stem Cell 2014 Jul 3;15(1)
2. *Seita J, Sahoo D, Rossi DJ, Battacharya D, Serwold T, Inlay MA, Ehrlich LIR, Fathman JW, Dill DL, Weissman IL.:
   “Gene Expression Commons: an open platform for absolute gene expression profiling.”
   PLoS ONE 2012;7(7)
3. *Seita J^* , Ji H^*, Ehrlich LI^* (equal contribution), Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP.:
   “Comprehensive methylome map of lineage commitment from haematopoietic progenitors.”
   Nature. 2010 Sep 16;467(7313)
4. *Seita J, Weissman IL.:
   “Hematopoietic stem cell: self-renewal versus differentiation.”
   Wiley Interdiscip Rev Systems Biology and Medicine. 2010 Nov-Dec;2(6)
5. *Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ.:
   “Epigenetic memory in induced pluripotent stem cells.”
   Nature. 2010 Sep 16:467(7313)
6. *Chen JY, Miyanishi M, Wang SK, Yamazaki S, Shinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL.:
   “Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.”
   Nature. 2016 Feb 11;530(7589)
7. *Chan CK, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, Tevlin R, Seita J, Vincent-Tompkins J, Wearda T, Lu WJ, Senarath-Yapa K, Chung MT, Marecic O, Tran M, Yan KS, Upton R, Walmsley GG, Lee AS, Sahoo D, Kuo CJ, Weissman IL, Longaker MT.:
   “Identification and specification of the mouse skeletal stem cell.”
   Cell. 2015 Jan 15;160(1-2)
8. *Rossi DJ*, Bryder D* (equal contribution), Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL.
   “Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.”
   Nature. 2007 Jun 7;447(7145)