Centers & Labs

RIKEN Preventive Medicine & Diagnosis Innovation Program (PMI)

Yoshihide  Hayashizaki(M.D., Ph.D.)
Program Director:
Yoshihide Hayashizaki
(M.D., Ph.D.)
The Preventive Medicine & Diagnosis Innovation Program deploys a broad range of research resources in physics, chemistry, engineering, biology and medical science to develop and establish more efficient disease detection technology that allows better disease prevention. Research groups taking part in the program are working on the discovery of new biomarkers, the development of detection technology for clinical practice, and the development of diagnosis kits. The program promotes collaborations within RIKEN and with universities, research institutes and hospitals both inside and outside Japan.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Clinical Medicine / Multidisciplinary

Research Subjects

  • Exploration of unmet medical needs and matching them with technical seeds in RIKEN
  • Biomarker discovery with CAGE (Cap Analysis of Gene Expression)
  • Development of a rapid detection kit of infectious disease

Selected Publications

  1. Kawai J., et al.:
    "Functional annotation of a full-length mouse cDNA collection"
    Nature 409, 685-690 (2001)
  2. Okazaki Y, et al.:
    "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs"
    Nature 420, 563-73 (2002)
  3. Carninci P, et al.:
    "The transcriptional landscape of the mammalian genome"
    Science 309, 1559-1563 (2005)
  4. Katayama S, et al.:
    "Antisense transcription in the mammalian transcriptome"
    Science 309, 1564-1566 (2005)
  5. Carninci P. et al.:
    "Genome-wide analysis of mammalian promoter architecture and evolution"
    Nature Genetics 38, 626-635 (2006)
  6. Suzuki H, et al.:
    "The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line"
    Nature Genetics, 41, 553-62 (2009)
  7. Ravasi T, et al.:
    "An atlas of combinatorial transcriptional regulation in mouse and man"
    Cell 140, 744-752 (2010)
  8. Forrest AR, et al.:
    "A promoter-level mammalian expression atlas"
    Nature 507, 462-470 (2014)
  9. Andersson R, et al.:
    "An atlas of active enhancers across human cell types and tissues"
    Nature 507, 455-461 (2014)
  10. Arner, et al.:
    "Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells"
    Science 347, 1010-1014 (2015)

Preventive medicine and diagnosis innovation program units (in each RIKEN center and institute)

  • Nucleic Acid Diagnostic System Development Unit (CLST)
    Kengo Usui(Ph.D.)

Contact information

2F Main Research Building,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan
Tel: +81-(0)48-462-1254

Email: contact_pmi [at]

Related links

Recent research results